UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain von Mžik, M., Žďárová-Karasová, J., Chalupová, K., Korábečný, J, Palička, V., Šesták, V.

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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease von Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

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UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data von Mzik, M., Sestak, V., Mezeiova, E., Korabecny, J., Hroch, M., Pejchal, J., Karasova-Zdarova, J.

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UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes von Novak, M., Svobodova, B., Konecny, J., Kuratkova, A., Nevosadova, L., Prchal, L., Korabecny, J., Lauschke, V.M., Soukup, O., Kučera, R.

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In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration von Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration von Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment von Kassa, J, Korabecny, J, Nepovimova, E, Misik, J

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P.5.a.001 The effect of novel tacrine-related cholinesterase inhibitors on cognitive deficit induced by 3-quinuclidinyl benzilate in rats von Kassa, J, Korabecny, J, Misik, J

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Tetroxime: reactivation potency - in vitro and in silico study von Kuca, K, Korabecny, J, Dolezal, R, Nepovimova, E, Soukup, O, Gorecki, L, Musilek, K

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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication von Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

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Huprines - an insight into the synthesis and biological properties von Mezeiova, Eva, Soukup, Ondrej, Korabecny, Jan

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P.8.b.001 Interaction of acetylcholinesterase reactivators with albumin von Zemek, F, Sepsova, V, Drtinova, L, Korabecny, J, Pohanka, M, Zdarova Karasova, J, Kuca, K

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P.760 Effects of novel cholinesterase inhibitors on mitochondrial respiration and MAO activity - in vitro study von Hroudová, J., Korábečný, J., Špilovská, K., Mezeiová, E., Górecki, L., Maliňák, D., Fišar, Z.

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Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation von Novak, Martin, Vajrychova, Marie, Koutsilieri, Stefania, Sismanoglou, Despoina-Christina, Kobrlova, Tereza, Prchal, Lukas, Svobodova, Barbora, Korabecny, Jan, Zarybnicky, Tomas, Raisova-Stuchlikova, Lucie, Skalova, Lenka, Lauschke, Volker M., Kučera, Radim, Soukup, Ondrej

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7-methoxyderivative of tacrine is a potent open channel blocker of NMDA receptors von Horak, M., Kaniakova, M., Soukup, O., Korabecny, J.

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Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia von Janockova, J., Kobrlova, T., Mezeiova, E., Dolezal, R., Korabecny, J., Soukup, O.

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P.525 Tacrine derivatives as potent inhibitors of N-methyl-D-aspartate receptors with neuroprotective activity von Horak, M., Kaniakova, M., Soukup, O., Korabecny, J., Kleteckova, L., Vales, K.

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1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats von Zdarova Karasova, Jana, Sestak, Vit, Korabecny, Jan, Mezeiova, Eva, Palicka, Vladimir, Kuca, Kamil, Mzik, Martin

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Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease von Soukup, O., Korabecny, J., Nepovimova, E., Karasova-Zdarova, J., Vales, K., Ricny, J., Jun, D., Kuca, K.

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Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine von Zhou, Yitian, Arribas, Gabriel Herras, Turku, Ainoleena, Jürgenson, Tuuli, Mkrtchian, Souren, Krebs, Kristi, Wang, Yi, Svobodova, Barbora, Milani, Lili, Schulte, Gunnar, Korabecny, Jan, Gastaldello, Stefano, Lauschke, Volker M

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