Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification von Liu, L., Toung, J.M., Jassowicz, A.F., Vijayaraghavan, R., Kang, H., Zhang, R., Kruglyak, K.M., Huang, H.J., Hinoue, T., Shen, H., Salathia, N.S., Hong, D.S., Naing, A., Subbiah, V., Piha-Paul, S.A., Bibikova, M., Granger, G., Barnes, B., Shen, R., Gutekunst, K., Fu, S., Tsimberidou, A.M., Lu, C., Eng, C., Moulder, S.L., Kopetz, E.S., Amaria, R.N., Meric-Bernstam, F., Laird, P.W., Fan, J.-B., Janku, F.

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169 BRAF mutation testing in cell-free DNA from plasma of patients with advanced cancers using a novel, rapid, automated molecular diagnostics prototype platform (Idylla™) von Janku, F, Huang, H.J, Claes, B, Falchook, G.S, Naing, A, Piha-Paul, S, Tsimberidou, A.M, Zinner, R.G, Karp, D.D, Fu, S, Subbiah, V, Hong, D.S, Wheler, J.J, Luthra, R.G, Patel, S.P, Kopetz, E.S, Sablon, E, Maertens, G, Kurzrock, R, Meric-Bernstam, F

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631P Using the unique somatic mutation profile of POLE loss of proof-reading mutation helps in selection of patients who may benefit from immunotherapy von Maddalena, G., Zeineddine, F.A., Chowdhury, S., Zeineddine, M., Yousef, A., Overman, M.J., Kopetz, E.S., Shen, J.P.Y-C.

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628P Immunotherapy in mismatch repair-deficient metastatic colorectal cancer: Long-term outcome and novel predictive markers von Stemmer, A., Margalit, O., Serpas, V., Strauss, G.Z., Thomas, J., Shash, P., Levanon, K., Shacham Shmueli, E., Kopetz, E.S., Overman, M.J., Boursi, B.

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587P Short lead time and high rates of concomitant radiographic recurrences for ctDNA-based minimal residual disease assays colorectal cancer (CRC) during surveillance: Results fro... von Eluri, M., Dasari, N.A., Maddalena, G., Bent, A., Pellatt, A.J., Balachandran Pillai, A., Alfaro-Munoz, K., Kell, R.J., Newhook, T., Uppal, A., Konishi, T., Morris, V., Kopetz, E.S.

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PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers von Dumbrava, E.E., Call, S.G., Huang, H.J., Stuckett, A.L., Madwani, K., Adat, A., Hong, D.S., Piha-Paul, S.A., Subbiah, V., Karp, D.D., Fu, S., Naing, A., Tsimberidou, A.M., Moulder, S.L., Koenig, K.H., Barcenas, C.H., Kee, B.K., Fogelman, D.R., Kopetz, E.S., Meric-Bernstam, F., Janku, F.

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MultiplexKRASG12/G13 mutation testing of unamplified cell-free DNA from the plasma of patients with advanced cancers using droplet digital polymerase chain reaction von Janku, F., Huang, H.J., Fujii, T., Shelton, D.N., Madwani, K., Fu, S., Tsimberidou, A.M., Piha-Paul, S.A., Wheler, J.J., Zinner, R.G., Naing, A., Hong, D.S., Karp, D.D., Cabrilo, G., Kopetz, E.S., Subbiah, V., Luthra, R., Kee, B.K., Eng, C., Morris, V.K., Karlin-Neumann, G.A., Meric-Bernstam, F.

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Complications of neglected cholelithiasis (quality and outcomes) account for significant surgical mortality in the elderly von Kopetz, E.S, Magnuson, T.H, Duncan, M.D, Bender, J.S, Lillemoe, K.D, Gordon, T.A, Cameron, J.L, Harmon, J.W

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