Supplementary Material for: Exploring molecular and cellular mechanisms and phenotypic characteristics of NAGLU Arg234Gly and Asp312Asn variants von H., KaymakcalanCelebiler, T., Barak, D.K., Rai, I., Kaya, S., Erbilgin, M., CikiliUytun, D., Oztop, H., Gumus, H., Per, S., Ceylaner, I., Bozkurt, M.I., Kontaridis, K., Bilguvar, N., Akhun, A., Kilincaslan, A.O., Caglayan, E.Z., Erson-Omay, M., Gunel, A.G., Ercan-Sencicek

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Arginine-Enhanced Enteral Nutrition Augments the Growth of a Nitric Oxide-Producing Tumor von Edwards, P.D., Topping, D., Kontaridis, M.I., Moldawer, L.L., Copeland, E.M., Lind, D.S.

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Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus von Wang, Jianxun, Mizui, Masayuki, Zeng, Li-Fan, Bronson, Roderick, Finnell, Michele, Terhorst, Cox, Kyttaris, Vasileios C, Tsokos, George C, Zhang, Zhong-Yin, Kontaridis, Maria I

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Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines von Lauriol, Jessica, Cabrera, Janel R, Roy, Ashbeel, Keith, Kimberly, Hough, Sara M, Damilano, Federico, Wang, Bonnie, Segarra, Gabriel C, Flessa, Meaghan E, Miller, Lauren E, Das, Saumya, Bronson, Roderick, Lee, Kyu-Ho, Kontaridis, Maria I

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of Leopard syndrome-associated Ptpn11 mutation von Marin, Talita M, Keith, Kimberly, Davies, Benjamin, Conner, David A, Guha, Prajna, Kalaitzidis, Demetrios, Wu, Xue, Lauriol, Jessica, Wang, Bo, Bauer, Michael, Bronson, Roderick, Franchini, Kleber G, Neel, Benjamin G, Kontaridis, Maria I

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PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development von Idrees, Muhammad, Xu, Lianguang, Song, Seok-Hwan, Joo, Myeong-Don, Lee, Kyeong-Lim, Muhammad, Tahir, El Sheikh, Marwa, Sidrat, Tabinda, Kong, Il-Keun

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Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development von Idrees, Muhammad, Oh, Seon-Hwa, Muhammad, Tahir, El-Sheikh, Marwa, Song, Seok-Hwan, Lee, Kyeong-Lim, Kong, Il-Keun

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Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling von Kim, Mihwa, Morales, Liza D, Jang, Ik-Soon, Cho, Yong-Yeon, Kim, Dae Joon

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The biological function of SHP2 in human disease von Li, S. M.

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SHP-2 Phosphatase Negatively Regulates the TRIF Adaptor Protein-Dependent Type I Interferon and Proinflammatory Cytokine Production von An, Huazhang, Zhao, Wei, Hou, Jin, Zhang, Yan, Xie, Yun, Zheng, Yuejuan, Xu, Hongmei, Qian, Cheng, Zhou, Jun, Yu, Yizhi, Liu, Shuxun, Feng, Gensheng, Cao, Xuetao

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Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome von Nakamura, Tomoki, Colbert, Melissa, Krenz, Maike, Molkentin, Jeffery D, Hahn, Harvey S, Dorn, Gerald W, IIRobbins, Jeffrey

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Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity von Miao, Jinmin, Bai, Yunpeng, Miao, Yiming, Qu, Zihan, Dong, Jiajun, Zhang, Ruo-Yu, Aggarwal, Devesh, Jassim, Brenson A, Nguyen, Quyen, Zhang, Zhong-Yin

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SHP-2 regulates myogenesis by coupling to FAK signaling pathway von de Oliveira, Michel V., Marin, Talita M., Clemente, Carolina F., Costa, Ana Paula Dalla, Judice, Carla C., Franchini, Kleber G.

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Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction von Gelb, Bruce D., Tartaglia, Marco

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas von Pfister, Stefan, Janzarik, Wibke G, Remke, Marc, Ernst, Aurélie, Werft, Wiebke, Becker, Natalia, Toedt, Grischa, Wittmann, Andrea, Kratz, Christian, Olbrich, Heike, Ahmadi, Rezvan, Thieme, Barbara, Joos, Stefan, Radlwimmer, Bernhard, Kulozik, Andreas, Pietsch, Torsten, Herold-Mende, Christel, Gnekow, Astrid, Reifenberger, Guido, Korshunov, Andrey, Scheurlen, Wolfram, Omran, Heymut, Lichter, Peter

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Specific Functions for ERK/MAPK Signaling during PNS Development von Newbern, Jason M., Li, Xiaoyan, Shoemaker, Sarah E., Zhou, Jiang, Zhong, Jian, Wu, Yaohong, Bonder, Daniel, Hollenback, Steven, Coppola, Giovanni, Geschwind, Daniel H., Landreth, Gary E., Snider, William D.

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Angiotensin II Alters Mitochondrial Membrane Potential and Lipid Metabolism in Rat Colonic Epithelial Cells von Toth, Darby D, Souder, 2nd, Christopher L, Patuel, Sarah, English, Cole D, Konig, Isaac, Ivantsova, Emma, Malphurs, Wendi, Watkins, Jacqueline, Anne Costa, Kaylie, Bowden, John A, Zubcevic, Jasenka, Martyniuk, Christopher J

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Non-Mammalian Models for Understanding Neurological Defects in RASopathies von Rodríguez-Martín, Mario, Báez-Flores, Juan, Ribes, Vanessa, Isidoro-García, María, Lacal, Jesus, Prieto-Matos, Pablo

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The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity von Heun, Yvonn, Grundler Groterhorst, Katharina, Pogoda, Kristin, Kraemer, Bjoern F, Pfeifer, Alexander, Pohl, Ulrich, Mannell, Hanna

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Paternally Inherited Noonan Syndrome Caused by a PTPN11 Variant May Exhibit Mild Symptoms: A Case Report and Literature Review von Han, Ji Yoon, Park, Joonhong

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