Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease von George, Alex, Pushkaran, Suvarnamala, Konstantinidis, Diamantis G., Koochaki, Sebastian, Malik, Punam, Mohandas, Narla, Zheng, Yi, Joiner, Clinton H., Kalfa, Theodosia A.

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Signaling and cytoskeletal requirements in erythroblast enucleation von Konstantinidis, Diamantis G., Pushkaran, Suvarnamala, Johnson, James F., Cancelas, Jose A., Manganaris, Stefanos, Harris, Chad E., Williams, David A., Zheng, Yi, Kalfa, Theodosia A.

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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease von Schroeder, Patricia, Fulzele, Keertik, Forsyth, Sanjeev, Ribadeneira, Maria D, Guichard, Sylvie, Wilker, Erik, Marshall, C Gary, Drake, Adam, Fessler, Rose, Konstantinidis, Diamantis G, Seu, Katie G, Kalfa, Theodosia A

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Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation von Konstantinidis, Diamantis G., Giger, Katie M., Risinger, Mary, Pushkaran, Suvarnamala, Zhou, Ping, Dexheimer, Phillip, Yerneni, Satwica, Andreassen, Paul, Klingmüller, Ursula, Palis, James, Zheng, Yi, Kalfa, Theodosia A.

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Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development von Zhang, Shuangmin, Konstantinidis, Diamantis G, Yang, Jun-Qi, Mizukawa, Benjamin, Kalim, Khalid, Lang, Richard A, Kalfa, Theodosia A, Zheng, Yi, Guo, Fukun

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Automated Oxygen Gradient Ektacytometry: A Novel Biomarker in Sickle Cell Anemia von Sadaf, Alina, Seu, Katie G, Thaman, Elizabeth, Fessler, Rose, Konstantinidis, Diamantis G, Bonar, Holly A, Korpik, Jennifer, Ware, Russell E, McGann, Patrick T, Quinn, Charles T, Kalfa, Theodosia A

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Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT‐4202), an Allosteric Activator of Pyruvate Kinase‐R, in Healthy Adults: A Randomized, Placebo‐Controlled, Double‐Bl... von Forsyth, Sanjeev, Schroeder, Patricia, Geib, James, Vrishabhendra, Leela, Konstantinidis, Diamantis G., LaSalvia, Kari, Ribadeneira, Maria D., Wu, Eric, Kelly, Patrick, Kalfa, Theodosia A.

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Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry von Konstantinidis, Diamantis G, Pushkaran, Suvarnamala, Giger, Katie, Manganaris, Stefanos, Zheng, Yi, Kalfa, Theodosia A

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Signaling Components Involved in Leptin-Induced Amplification of the Atherosclerosis-Related Properties of Human Monocytes von Konstantinidis, Diamantis, Paletas, Konstantinos, Koliakos, George, Kaloyianni, Martha

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Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis von Romano, Laurel, Seu, Katie G., Papoin, Julien, Muench, David E., Konstantinidis, Diamantis, Olsson, André, Schlum, Katrina, Chetal, Kashish, Chasis, Joel Anne, Mohandas, Narla, Barnes, Betsy J., Zheng, Yi, Grimes, H. Leighton, Salomonis, Nathan, Blanc, Lionel, Kalfa, Theodosia A.

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Ex-Vivo FT-4202 Treatment Improves Hemoglobin Oxygen Affinity and Membrane Health in Red Blood Cells of Patients with Hemoglobin SS and Hemoglobin SC Disease Irrespective of Prior... von Konstantinidis, Diamantis G., Fessler, Rose, Giger Seu, Katie, Patel, Bhargav, Korpik, Jennifer B, Fulzele, Keertik, Guichard, Sylvie, Kalfa, Theodosia A.

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Angiotensin Signaling Is Essential for Stress Erythropoiesis but Results in Retention of Dysfunctional Mitochondria in Erythrocytes That Generate Excessive Reactive Oxygen Species von Rai, Parul, Roy, Swarnava, Konstantinidis, Diamantis G., Ponny, Sithara Raju, Mpollo, Marthe-sandrine Eiymo Mwa, Shrestha, Archana, Kalfa, Theodosia A., Malik, Punam

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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Diseases von Schroeder, Patricia, Fulzele, Keertik, Forsyth, Sanjeev, Ribadeneira, Maria D., Guichard, Sylvie, Wilker, Erik, Marshall, C. Gary, Drake, Adam, Fessler, Rose, Konstantinidis, Diamantis G., Seu, Katie G., Kalfa, Theodosia A.

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Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of P... von Kalfa, Theodosia A., Kuypers, Frans A, Telen, Marilyn J., Malik, Punam, Konstantinidis, Diamantis G., Estepp, Jeremy H., Kim, Hyon J., Saraf, Santosh L., Wilson, Lindsey, Ribadeneira, Maria D, Forsyth, Sanjeev, Schroeder, Patricia, Drake, Adam, Polyanskaya, Olga, Kelly, Patrick, Biernat, Lukasz

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The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis von Giger Seu, Katie, Romano, Laurel, Papoin, Julien, Muench, Edward David, Konstantinidis, Diamantis, Olsson, André, Chetal, Kashish, Chasis, Joel Anne, Narla, Mohandas, Salomonis, Nathan, Grimes, H Leighton, Blanc, Lionel, Kalfa, Theodosia A.

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Gene targeting of RhoA reveals its essential role in thymocyte development and metabolism (LYM7P.718) von Guo, Fukun, Zhang, Shuangmin, Konstantinidis, Diamantis, Yang, Jun-Qi, Kalfa, Theodosia, Zheng, Yi

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Cellular Hydration and Oxidation As Phenotype Modifiers in Sickle Cell Anemia von Risinger, Mary A, Dagaonkar, Neha, Christakopoulos, Georgios E, Liu, Jie, Giger Seu, Katie, Konstantinidis, Diamantis G, Quinn, Charles T, Chonat, Satheesh, Joiner, Clinton H, Zhang, Kejian, Kalfa, Theodosia A

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Reactive Oxygen Species Produced by NADPH Oxidase Contribute to Cardiac Pathology in a Mouse Model of Sickle Cell Disease von Christakopoulos, Georgios E, Chonat, Satheesh, Valiente-Alandi, Inigo, Konstantinidis, Diamantis G, Schleper, Amanda, Bakeer, Nihal, Loberg, Anastacia, Blaxall, Burns C, Zheng, Yi, James, Jeanne, Malik, Punam, Kalfa, Theodosia A

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The Ambiguous Role of the Na⁺-H⁺ Exchanger Isoform 1 (NHE1) in Leptin-Induced Oxidative Stress in Human Monocytes von Konstantinidis, Diamantis, Paletas, Konstantinos, Koliakos, George, Kaloyianni, Martha

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Erythroid Specific RhoA Deficiency Causes Dysplastic and Inefficient Fetal Erythropoiesis with Lethal Embryonic Anemia Due to Defects in Erythroblast Cytokinesis and Enucleation von Konstantinidis, Diamantis, Pushkaran, Suvarnamala, Klingmuller, Ursula, Palis, James, Zheng, Yi, Kalfa, Theodosia A

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