Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism von Baran, Natalia, Han, Lina, Stuani, Lucille, Cavazos, Antonio, Cooper, Laurie, Ramage, Cassandra L., Kuruvilla, Vinitha MARY, Zhang, Qi, Sabtier, Marie, Boet, Emeline, Gay, Jason P, Feng, Ninping, Battula, Venkata Lokesh, Chu-Van, Emeline, Castelli, Florence, Carroll, Martin, Konoplev, Sergej Naumovich, Thakral, Beenu, Daver, Naval, Marszalek, Joseph R, Ge, Yubin, Andreeff, Michael, Sarry, Jean-Emmanuel, Konopleva, Marina Y.

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Outcomes in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Longer-Term Follow-up Demonstrates Poor Outcomes in Patients with Skin-Only Presentation von Pemmaraju, Naveen, Kantarjian, Hagop M., Khoury, Joseph David, O'Brien, Susan M., Cortes, Jorge E., Garcia-Manero, Guillermo, Jabbour, Elias J., Jain, Nitin, Aung, Phyu, Yin, C. Cameron, Konoplev, Sergej Naumovich, Patel, Keyur, Pierce, Sherry A., Zhou, Lingsha, Konopleva, Marina Y.

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CD123 Expression Patterns and Potential of IMGN632, a CD123-Targeted Antibody Drug Conjugate, in Acute Lymphoblastic Leukemia von Angelova, Evgeniya, Audette, Charlene, Kovtun, Yelena, Daver, Naval, Wang, Sa A., Pierce, Sherry, Konoplev, Sergej Naumovich, Jorgensen, Jeffrey L., Konopleva, Marina, Zweidler-McKay, Patrick A., Kantarjian, Hagop M., Jabbour, Elias J., Khoury, Joseph David

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Pre-Clinical Studies of Allogeneic Anti-CD123 CAR T-Cells for the Therapy of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) von Cai, Tianyu, Galetto, Roman, Gouble, Agnès, Smith, Julianne, Cavazos, Antonio, Han, Lina, Zhang, Qi, Kuruvilla, Vinitha Mary, Konoplev, Sergej Naumovich, Neelapu, Sattva S., Lane, Andrew A., Guzman, Monica L., Kantarjian, Hagop M., Pemmaraju, Naveen, Konopleva, Marina

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Abstract 2560: Preclinical efficacy of allogeneic anti-CD123 CAR T-cells for the therapy of blastic plasmacytoid dendritic cell neoplasm (BPDCN) von Cai, Tianyu, Black, Kathryn L., Naqvi, Ammar, Galetto, Roman, Gouble, Agnès, Smith, Julianne, Cavazos, Antonio, Han, Lina, Zhang, Qi, Kuruvilla, Vinitha, Konoplev, Sergej Naumovich Sergej, Neelapu, Sattva S., Lane, Andrew A., Guzman, Monica L., Kantarjian, Hagop, Thomas-Tikhonenko, Andrei, Pemmaraju, Naveen, Konopleva, Marina

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Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and G... von Baran, Natalia, Lodi, Alessia, Sweeney, Shannon Renee, Renu, Pandey, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Herranz, Daniel, Skwarska, Anna, Warmoes, Marc, Davis, R. Eric, Harutyunyan, Karine, Feng, Ningping, Gay, Jason P, Konoplev, Sergej Naumovich, Kaminski, Marcin, Kovacs, Jeffrey J, Du, Di, Jabbour, Elias J., Ferrando, Adolfo A., Di Francesco, Maria E, Lorenzi, Philip L, Marszalek, Joseph R, Tiziani, Stefano, Konopleva, Marina Y.

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Long-Term Outcomes in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) von Pemmaraju, Naveen, Kantarjian, Hagop M., Khoury, Joseph David, O'Brien, Susan M., Cortes, Jorge E., Garcia-Manero, Guillermo, Jabbour, Elias J., Jain, Nitin, Alvarado, Yesid, Duvic, Madeleine, Aung, Phyu, Qazilbash, Muzaffar H., Yin, C. Cameron, Konoplev, Sergej Naumovich, Patel, Keyur P., Pierce, Sherry, Brandt, Mark, Konopleva, Marina

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Ruxolitinib or Dasatinib in Combination with Chemotherapy for Patients with Relapsed/Refractory Philadelphia (Ph)-like Acute Lymphoblastic Leukemia: A Phase I-II Trial von Jain, Nitin, Jabbour, Elias J., McKay, Patrick Zweider, Ravandi, Farhad, Takahashi, Koichi, Kadia, Tapan, Wierda, William G, Rytting, Michael E., Nunez, Cesar, Patel, Keyur, Lu, Xinyan, Tang, Guilin, Konoplev, Sergej Naumovich, Wang, Sa A., Han, Lina, Thakral, Beenu, Roberts, Kathryn G., Deshmukh, April, Garris, Rebecca, Jorgensen, Jeffrey L., Cavazos, Antonio, Verstovsek, Srdan, Garcia-Manero, Guillermo, O'Brien, Susan M., Cortes, Jorge E., Mullighan, Charles G., Kantarjian, Hagop M., Konopleva, Marina

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Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inh... von Hurrish, Katie H., Su, Yongwei, Patel, Shraddha, Wiley, Sandra E., Hou, Zhanjun, Carter, Jenna, Kalpage, Hasini, Hüttemann, Maik, Weng, Connie, Edwards, Holly, Polin, Lisa, Li, Jing, Yang, Jay, Matherly, Larry H., Konoplev, Sergej Naumovich, Taub, Jeffrey W., Konopleva, Marina, Ge, Yubin, Baran, Natalia

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