The atomic-resolution structure of human caspase-8, a key activator of apoptosis von Watt, William, Koeplinger, Kenneth A, Mildner, Ana M, Heinrikson, Robert L, Tomasselli, Alfredo G, Watenpaugh, Keith D

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Equilibrium distribution of HIV antiviral drugs into human peripheral blood mononuclear cells (PBMC) is controlled by free drug concentration in the extracellular medium von Koeplinger, Kenneth A, Raub, Thomas J, Padbury, Guy E, Zhao, Zhiyang

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Determination of warfarin-human serum albumin protein binding parameters by an improved Hummel-Dreyer high-performance liquid chromatographic method using internal surface reversed... von Pinkerton, Thomas C, Koeplinger, Kenneth A

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Impact of pH on Plasma Protein Binding in Equilibrium Dialysis von Kochansky, Christopher J, McMasters, Daniel R, Lu, Ping, Koeplinger, Kenneth A, Kerr, Haley H, Shou, Magang, Korzekwa, Kenneth R

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Chromatographic Measurement of Drug–Protein Interaction: Determination of HIV Protease Inhibitor–Serum Albumin Association von Koeplinger, Kenneth A., Zhao, Zhiyang

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Caspase 8: An Efficient Method for Large-Scale Autoactivation of Recombinant Procaspase 8 by Matrix Adsorption and Characterization of the Active Enzyme von Koeplinger, Kenneth A., Mildner, Ana M., Leone, Joseph W., Wheeler, Jean S., Heinrikson, Robert L., Tomasselli, Alfredo G.

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[W206R]-Procaspase 3: An Inactivatable Substrate for Caspase 8 von Rank, Kenneth B., Mildner, Ana M., Leone, Joseph W., Koeplinger, Kenneth A., Chou, K.C., Tomasselli, Alfredo G., Heinrikson, Robert L., Sharma, Satish K.

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Stereoselective hydroxylation of nonpeptidic HIV protease inhibitors by CYP2D6 von Zhao, Zhiyang, Koeplinger, Kenneth A., Waldon, Daniel J.

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Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection von Hecker, Scott J, Reddy, K. Raja, van Poelje, Paul D, Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M, Olsen, David B, Koeplinger, Kenneth A, Boyer, Serge H, Linemeyer, David L, MacCoss, Malcolm, Erion, Mark D

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Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity von Zhao, Z, Koeplinger, K A, Padbury, G E, Hauer, M J, Bundy, G L, Banitt, L S, Schwartz, T M, Zimmermann, D C, Harbach, P R, Mayo, J K, Aaron, C S

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Contribution of serum protein association to discrepancy between the in vivo and in vitro UDS results for 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) von Zhao, Zhiyang, Koeplinger, Kenneth A, Padbury, Guy E, Aaron, Charles S, Harbach, Philip R, Mayo, Judy K, Mattes, William B, Bundy, Gordon L

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High-performance liquid chromatographic separation of peptides on a diol-gly-phe-phe tripeptide-bonded phase von Pinkerton, Thomas C., Koeplinger, Kenneth A.

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Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors von Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

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Synthesis and dimerization of two cross-conjugated trienes: 3-methylene-1,4-pentadiene and 1,2,3-trimethylenecyclohexane von Trahanovsky, Walter S, Koeplinger, Kenneth A

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Determination of warfarin-human serum albumin protein binding parameters by an improved Hummel-Dreyer high-performance liquid chromatographi method using internal surface reversed-... von PINKERTON, T. C, KOEPLINGER, K. A

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SYNTHESIS AND DIMERIZATION OF 2 CROSS-CONJUGATED TRIENES - 3-METHYLENE-1,4-PENTADIENE AND 1,2,3-TRIMETHYLENECYCLOHEXANE von TRAHANOVSKY, WS, KOEPLINGER, KA

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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.

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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C, N Di Marco, Christina, Chang, Ronald K, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Fuerst, Joy, Hartman, George D, Bilodeau, Mark T, Ray, William J, Kuduk, Scott D

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Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry von Lagrutta, Armando, Regan, Christopher P., Zeng, Haoyu, Imredy, John P., Koeplinger, Kenneth, Morissette, Pierre, Liu, Liping, Wollenberg, Gordon, Brynczka, Christopher, Lebrón, José, DeGeorge, Joseph, Sannajust, Frederick

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Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold von Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Pitts, Daniel R, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T, Ray, William J

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