1201 NO CLINICALLY SIGNIFICANT PHARMACOKINETIC INTERACTION BETWEEN SOVAPREVIR AND ACH-3102 IN HEALTHY VOLUNTEERS von Hui, J, Robarge, L, Robison, H, Kocinsky, H, Deshpande, M

Volltext

LP06 : Sustained virologic response after ACH-3102 and sofosbuvir treatment for 8 or 6 weeks: A phase 2 “proxy” study von Gane, E, Schwabe, C, Mader, M, Suri, V, Donohue, M, Huang, M, Hui, J, Yang, J, Robison, H, Apelian, D, Kocinsky, H

Volltext

1200 FINDINGS FROM CLINICAL VIROLOGY STUDIES ON SOVAPREVIR, A PHASE 2 HCV NS3 PROTEASE INHIBITOR, INDICATE A HIGH PHARMACOLOGICAL BARRIER TO VIRAL RESISTANCE von Fabrycki, J, Zhao, Y, Patel, D, Yang, G, Podos, S, Yang, W, Robison, H, Robarge, L, Kocinsky, H, Olek, E, Deshpande, M, Huang, M

Volltext

1199 FINDINGS FROM CLINICAL VIROLOGY STUDIES ON ACH-3102 ARE CONSISTENT WITH PRECLINICAL OBSERVATIONS ON ITS IMPROVED POTENCY AGAINST GENOTYPE-1a HCV AND RESISTANT VARIANTS von Yang, G, Patel, D, Zhao, Y, Fabrycki, J, Yang, W, Podos, S, Robison, H, Robarge, L, Kocinsky, H, Deshpande, M, Huang, M

Volltext

847 ACH-2684 DEMONSTRATES POTENT VIRAL SUPPRESSION IN GENOTYPE 1 HEPATITIS C PATIENTS WITH AND WITHOUT CIRRHOSIS: SAFETY, PHARMACOKINETIC, AND VIRAL KINETIC ANALYSIS von Lawitz, E, Hill, J, Vince, B, Murillo, A, Gruener, D, Marbury, T, Demicco, M, Agarwal, A, Robison, H, Huang, M, Robarge, L, Hui, J, Olek, E, Deshpande, M, Kocinsky, H

Volltext

784 VIRAL KINETICS MODELING TO PREDICT cEVR AND AID IN DOSE SELECTION DECISIONS FOR PHASE-2/3 CLINICAL TRIALS von Agarwal, A, Zhang, B, Robison, H, Robarge, L, Zhao, Y, Fabrycki, J, Patel, D, Yang, G, Huang, M, Hui, J, Kocinsky, H, Olek, E, Deshpande, M

Volltext

876 ACH-3102, A SECOND GENERATION NS5A INHIBITOR, DEMONSTRATES POTENT ANTIVIRAL ACTIVITY IN PATIENTS WITH GENOTYPE 1a HCV INFECTION DESPITE THE PRESENCE OF BASELINE NS5A-RESISTANT... von Muir, A, Hill, J, Lawitz, E, Marbury, T, Robarge, L, Robison, H, Hui, J, Huang, M, Agarwal, A, Perelson, A, Deshpande, M, Kocinsky, H

Volltext

Corrigendum to PHASE 2 STUDY TO EVALUATE EFFICACY AND SAFETY OF PEGCETACOPLAN IN THE TREATMENT OF PATIENTS WITH POSTTRANSPLANT RECURRENCE OF C3G OR IC MPGN von Pickering, M., Dixon, B., Walker, P., Fakhowri, F., Soomro, I., Cook, T., Zhang, Z., Ahmad, Z., Kocinsky, H.

Volltext

POS-047 PHASE 2 STUDY TO EVALUATE EFFICACY AND SAFETY OF PEGCETACOPLAN IN THE TREATMENT OF PATIENTS WITH POSTTRANSPLANT RECURRENCE OF C3G OR IC MPGN von Palakow, N., Pickering, M., Dixon, B., Walker, P., Fakhowri, F., Soomro, I., Cook, T., Zhang, Z., Ahmad, Z., Kocinsky, H.

Volltext

POS-048 PHASE 3, RANDOMIZED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PEGCETACOPLAN IN TREATMENT OF C3G OR IC-MPGN von Remuzzi, G., Dixon, B., Fakhouri, F., Pickering, M., Cook, T., Kavanagh, D., Walker, P., Licht, C., Appel, G., Vivarelli, M., Zhang, Z., Li, L., Kocinsky, H.

Volltext

Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites von Kocinsky, Hetal S, Girardi, Adriana C C, Biemesderfer, Daniel, Nguyen, Thao, Mentone, Sueann, Orlowski, John, Aronson, Peter S

Volltext

Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron von Nguyen, Mien T X, Yang, Li E, Fletcher, Nicholas K, Lee, Donna H, Kocinsky, Hetal, Bachmann, Sebastian, Delpire, Eric, McDonough, Alicia A

Volltext

Effects of K + -deficient diets with and without NaCl supplementation on Na + , K + , and H 2 O transporters' abundance along the nephron von Nguyen, Mien T. X., Yang, Li E., Fletcher, Nicholas K., Lee, Donna H., Kocinsky, Hetal, Bachmann, Sebastian, Delpire, Eric, McDonough, Alicia A.

Volltext

Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron von Nguyen, Mien T X, Yang, Li E, Fletcher, Nicholas K, Lee, Donna H, Kocinsky, Hetal, Bachmann, Sebastian, Delpire, Eric, McDonough, Alicia A

Volltext

Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron von NGUYEN, Mien T. X, YANG, Li E, FLETCHER, Nicholas K, LEE, Donna H, KOCINSKY, Hetal, BACHMANN, Sebastian, DELPIRE, Eric, MCDONOUGH, Alicia A

Volltext