Targeting transcription factors in acute myeloid leukemia von Takei, Hisashi, Kobayashi, Susumu S.

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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells von Fujimoto, Yumi, Morita, Tomoko Yamamori, Ohashi, Akihiro, Haeno, Hiroshi, Hakozaki, Yumi, Fujii, Masanori, Kashima, Yukie, Kobayashi, Susumu S., Mukohara, Toru

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Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3–PD-L1 ≥50% Expression in Lung Adenocarcinoma von Rangachari, Deepa, VanderLaan, Paul A., Shea, Meghan, Le, Xiuning, Huberman, Mark S., Kobayashi, Susumu S., Costa, Daniel B.

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance von Nilsson, Monique B., Yang, Yan, Heeke, Simon, Patel, Sonia A., Poteete, Alissa, Udagawa, Hibiki, Elamin, Yasir Y., Moran, Cesar A., Kashima, Yukie, Arumugam, Thiruvengadam, Yu, Xiaoxing, Ren, Xiaoyang, Diao, Lixia, Shen, Li, Wang, Qi, Zhang, Minying, Robichaux, Jacqulyne P., Shi, Chunhua, Pfeil, Allyson N., Tran, Hai, Gibbons, Don L., Bock, Jason, Wang, Jing, Minna, John D., Kobayashi, Susumu S., Le, Xiuning, Heymach, John V.

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The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer von Izumi, Hiroki, Matsumoto, Shingo, Liu, Jie, Tanaka, Kosuke, Mori, Shunta, Hayashi, Kumiko, Kumagai, Shogo, Shibata, Yuji, Hayashida, Takuma, Watanabe, Kana, Fukuhara, Tatsuro, Ikeda, Takaya, Yoh, Kiyotaka, Kato, Terufumi, Nishino, Kazumi, Nakamura, Atsushi, Nakachi, Ichiro, Kuyama, Shoichi, Furuya, Naoki, Sakakibara-Konishi, Jun, Okamoto, Isamu, Taima, Kageaki, Ebi, Noriyuki, Daga, Haruko, Yamasaki, Akira, Kodani, Masahiro, Udagawa, Hibiki, Kirita, Keisuke, Zenke, Yoshitaka, Nosaki, Kaname, Sugiyama, Eri, Sakai, Tetsuya, Nakai, Tokiko, Ishii, Genichiro, Niho, Seiji, Ohtsu, Atsushi, Kobayashi, Susumu S., Goto, Koichi

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Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells von Takenaka, Tomoya, Nakai, Shinya, Katayama, Miku, Hirano, Mami, Ueno, Natsumi, Noguchi, Kosuke, Takatani-Nakase, Tomoka, Fujii, Ikuo, Kobayashi, Susumu S., Nakase, Ikuhiko

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EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas von Jorge, Susan E, Lucena-Araujo, Antonio R, Yasuda, Hiroyuki, Piotrowska, Zofia, Oxnard, Geoffrey R, Rangachari, Deepa, Huberman, Mark S, Sequist, Lecia V, Kobayashi, Susumu S, Costa, Daniel B

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Mathematical analysis identifies the optimal treatment strategy for epidermal growth factor receptor-mutated non-small cell lung cancer von Yu, Qian, Kobayashi, Susumu S., Haeno, Hiroshi

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EGFR-Mutated Lung Cancers Resistant to Osimertinib through EGFR C797S Respond to First-Generation Reversible EGFR Inhibitors but Eventually Acquire EGFR T790M/C797S in Preclinical... von Rangachari, Deepa, To, Ciric, Shpilsky, Jason E., VanderLaan, Paul A., Kobayashi, Susumu S., Mushajiang, Mierzhati, Lau, Christie J., Paweletz, Cloud P., Oxnard, Geoffrey R., Jänne, Pasi A., Costa, Daniel B.

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In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer von Hirano, Toshiyuki, Yasuda, Hiroyuki, Tani, Tetsuo, Hamamoto, Junko, Oashi, Ayano, Ishioka, Kota, Arai, Daisuke, Nukaga, Shigenari, Miyawaki, Masayoshi, Kawada, Ichiro, Naoki, Katsuhiko, Costa, Daniel B, Kobayashi, Susumu S, Betsuyaku, Tomoko, Soejima, Kenzo

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Long-read sequencing for non-small-cell lung cancer genomes von Sakamoto, Yoshitaka, Xu, Liu, Seki, Masahide, Yokoyama, Toshiyuki T, Kasahara, Masahiro, Kashima, Yukie, Ohashi, Akihiro, Shimada, Yoko, Motoi, Noriko, Tsuchihara, Katsuya, Kobayashi, Susumu S, Kohno, Takashi, Shiraishi, Yuichi, Suzuki, Ayako, Suzuki, Yutaka

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TAS2940, a novel brain‐penetrable pan‐ERBB inhibitor, for tumors with HER2 and EGFR aberrations von Oguchi, Kei, Araki, Hikari, Tsuji, Shingo, Nakamura, Masayuki, Miura, Akihiro, Funabashi, Kaoru, Osada, Akiko, Tanaka, Sakiho, Suzuki, Takamasa, Kobayashi, Susumu S., Mizuarai, Shinji

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TIP60 is required for tumorigenesis in non‐small cell lung cancer von Shibahara, Daisuke, Akanuma, Naoki, Kobayashi, Ikei S., Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Jiang, Feng, Prin, P. Nicholas, Pan, Gilbert, Wong, Kwok‐Kin, Costa, Daniel B., Bararia, Deepak, Tenen, Daniel G., Watanabe, Hideo, Kobayashi, Susumu S.

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Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer von Izumi, Motohiro, Fujii, Masanori, Kobayashi, Ikei S., Ho, Vivian, Kashima, Yukie, Udagawa, Hibiki, Costa, Daniel B., Kobayashi, Susumu S.

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Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms von Takei, Hisashi, Coelho‐Silva, Juan Luiz, Tavares Leal, Cristina, Queiroz Arantes Rocha, Adriana, Mantello Bianco, Thiago, Welner, Robert S., Mishima, Yuta, Kobayashi, Ikei S., Mullally, Ann, Lima, Keli, Machado‐Neto, João Agostinho, Kobayashi, Susumu S., Lobo de Figueiredo‐Pontes, Lorena

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NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells von de Miranda, Lívia Bassani Lins, Lima, Keli, Coelho-Silva, Juan Luiz, Traina, Fabiola, Kobayashi, Susumu S., Machado-Neto, João Agostinho

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Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer von Ishioka, Kota, Yasuda, Hiroyuki, Hamamoto, Junko, Terai, Hideki, Emoto, Katsura, Kim, Tae-Jung, Hirose, Shigemichi, Kamatani, Takashi, Mimaki, Sachiyo, Arai, Daisuke, Ohgino, Keiko, Tani, Tetsuo, Masuzawa, Keita, Manabe, Tadashi, Shinozaki, Taro, Mitsuishi, Akifumi, Ebisudani, Toshiki, Fukushima, Takahiro, Ozaki, Mari, Ikemura, Shinnosuke, Kawada, Ichiro, Naoki, Katsuhiko, Nakamura, Morio, Ohtsuka, Takashi, Asamura, Hisao, Tsuchihara, Katsuya, Hayashi, Yuichiro, Hegab, Ahmed E, Kobayashi, Susumu S, Kohno, Takashi, Watanabe, Hideo, Ornitz, David M, Betsuyaku, Tomoko, Soejima, Kenzo, Fukunaga, Koichi

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EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors von Vasconcelos, Pedro E.N.S., Gergis, Carol, Viray, Hollis, Varkaris, Andreas, Fujii, Masanori, Rangachari, Deepa, VanderLaan, Paul A., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.

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Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator von Takei, Hisashi, Fukuda, Hirofumi, Pan, Gilbert, Yamazaki, Hiroyuki, Matsumoto, Tadahiko, Kazuma, Yasuhiro, Fujii, Masanori, Nakayama, Sohei, Kobayashi, Ikei S., Shindo, Keisuke, Yamashita, Riu, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Kobayashi, Susumu S.

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Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations von Vasconcelos, Pedro E.N.S., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.

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