Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer von Kashima, Yukie, Shibahara, Daisuke, Suzuki, Ayako, Muto, Kyoko, Kobayashi, Ikei S, Plotnick, David, Udagawa, Hibiki, Izumi, Hiroki, Shibata, Yuji, Tanaka, Kosuke, Fujii, Masanori, Ohashi, Akihiro, Seki, Masahide, Goto, Koichi, Tsuchihara, Katsuya, Suzuki, Yutaka, Kobayashi, Susumu S

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TIP60 is required for tumorigenesis in non‐small cell lung cancer von Shibahara, Daisuke, Akanuma, Naoki, Kobayashi, Ikei S., Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Jiang, Feng, Prin, P. Nicholas, Pan, Gilbert, Wong, Kwok‐Kin, Costa, Daniel B., Bararia, Deepak, Tenen, Daniel G., Watanabe, Hideo, Kobayashi, Susumu S.

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Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms von Takei, Hisashi, Coelho‐Silva, Juan Luiz, Tavares Leal, Cristina, Queiroz Arantes Rocha, Adriana, Mantello Bianco, Thiago, Welner, Robert S., Mishima, Yuta, Kobayashi, Ikei S., Mullally, Ann, Lima, Keli, Machado‐Neto, João Agostinho, Kobayashi, Susumu S., Lobo de Figueiredo‐Pontes, Lorena

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Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer von Izumi, Motohiro, Fujii, Masanori, Kobayashi, Ikei S., Ho, Vivian, Kashima, Yukie, Udagawa, Hibiki, Costa, Daniel B., Kobayashi, Susumu S.

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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1 von Aftab, Fareesa, Rodriguez-Fuguet, Alice, Silva, Luis, Kobayashi, Ikei S., Sun, Jiao, Politi, Katerina, Levantini, Elena, Zhang, Wei, Kobayashi, Susumu S., Zhang, Wen Cai

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Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα von Sridhar, Radhakrishnan, Takei, Hisashi, Syed, Riyaz, Kobayashi, Ikei S, Hui, Liu Bee, Kamal, Ahmed, Tenen, Daniel G, Kobayashi, Susumu S

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EGFR exon 19 insertion EGFR-K745_E746insIPVAIK and others with rare XPVAIK amino-acid insertions: Preclinical and clinical characterization of the favorable therapeutic window to a... von Shaffer, William, Kobayashi, Ikei S., Sentana-Lledo, Daniel, Sundararaman, Shriram, Lee, Meghan D., Rangachari, Deepa, VanderLaan, Paul A., Kobayashi, Susumu S., Costa, Daniel B.

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EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active... von Kobayashi, Ikei S, Viray, Hollis, Rangachari, Deepa, Kobayashi, Susumu S, Costa, Daniel B

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EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors von Vasconcelos, Pedro E.N.S., Gergis, Carol, Viray, Hollis, Varkaris, Andreas, Fujii, Masanori, Rangachari, Deepa, VanderLaan, Paul A., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.

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Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator von Takei, Hisashi, Fukuda, Hirofumi, Pan, Gilbert, Yamazaki, Hiroyuki, Matsumoto, Tadahiko, Kazuma, Yasuhiro, Fujii, Masanori, Nakayama, Sohei, Kobayashi, Ikei S., Shindo, Keisuke, Yamashita, Riu, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Kobayashi, Susumu S.

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Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations von Vasconcelos, Pedro E.N.S., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.

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The Impact of On-Target Resistance Mediated by EGFR-T790M or EGFR-C797S on EGFR Exon 20 Insertion Mutation Active Tyrosine Kinase Inhibitors von Kobayashi, Ikei S., Shaffer, William, Viray, Hollis, Rangachari, Deepa, VanderLaan, Paul A., Kobayashi, Susumu S., Costa, Daniel B.

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NAD Modulates DNA Methylation and Cell Differentiation von Ummarino, Simone, Hausman, Clinton, Gaggi, Giulia, Rinaldi, Lucrezia, Bassal, Mahmoud A, Zhang, Yanzhou, Seelam, Andy Joe, Kobayashi, Ikei S, Borchiellini, Marta, Ebralidze, Alexander K, Ghinassi, Barbara, Trinh, Bon Q, Kobayashi, Susumu S, Di Ruscio, Annalisa

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Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation von Radhakrishnan, Sridhar, Syed, Riyaz, Takei, Hisashi, Kobayashi, Ikei S., Nakamura, Eugene, Sultana, Farheen, Kamal, Ahmed, Tenen, Daniel G., Kobayashi, Susumu S.

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Roles of coagulation pathway and factor Xa in rat mesangioproliferative glomerulonephritis von Nomura, Keiko, Liu, Ning, Nagai, Kojiro, Hasegawa, Takamichi, Kobayashi, Ikei, Nogaki, Fumiaki, Tanaka, Misa, Arai, Hidenori, Fukatsu, Atsushi, Kita, Toru, Ono, Takahiko

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Abstract 5440: Role of tyrosine phosphorylation of β-catenin in EGFR-mutant lung cancer von Fujii, Masanori, Nakayama, Sohei, Shimizu, Kohei, Takei, Hisashi, Ando, Mariko, Heo, Eunyoung, Kobayashi, ikei, Pan, Gilbert, Inuzuka, Hiroyuki, Kobayashi, Susumu

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Abstract 354: Role of KAT5 in lung tumorigenesis von Pan, Gilbert, Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Kobayashi, Ikei, Tenen, Daniel G., Watanabe, Hideo, Kobayashi, Susumu S.

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Abstract 3460: Targeting the MIF-CD74 axis to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer von Izumi, Motohiro, Lee, Meghan, Shibahara, Daisuke, Kobayashi, Ikei S., Plotnick, David, Kobayashi, Susumu S.

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Abstract 320: Met/Ror1-β-catenin-Bcl-xL axis contributes to the emergence of drug-tolerant cells that evolve into resistant tumors in EGFR -mutant lung cancer von Fujii, Masanori, Nakayama, Sohei, Akanuma, Naoki, Pan, Gilbert, Kobayashi, Ikei S., Takei, Hisashi, Shimizu, Kohei, Ando, Mariko, Heo, Eunyoung, Gergis, Carol, Inuzuka, Hiroyuki, Wei, Wenyi, Costa, Daniel B., Kobayashi, Susumu S.

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Alternative Splicing of APOBEC3D Generates Functional Diversity and Its Role As a DNA Mutator von Takei, Hisashi, Fujii, Masanori, Nakayama, Sohei, Kobayashi, Ikei, Shindo, Keisuke, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Kobayashi, Susumu

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