A Small Nonrule of 3 Compatible Fragment Library Provides High Hit Rate of Endothiapepsin Crystal Structures with Various Fragment Chemotypes von Köster, Helene, Craan, Tobias, Brass, Sascha, Herhaus, Christian, Zentgraf, Matthias, Neumann, Lars, Heine, Andreas, Klebe, Gerhard

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Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry von Mondal, Milon, Radeva, Nedyalka, Köster, Helene, Park, Ahyoung, Potamitis, Constantinos, Zervou, Maria, Klebe, Gerhard, Hirsch, Anna K. H.

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Tracing Binding Modes in Hit-to-Lead Optimization: Chameleon-Like Poses of Aspartic Protease Inhibitors von Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.

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One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists von Schiebel, Johannes, Radeva, Nedyalka, Köster, Helene, Metz, Alexander, Krotzky, Timo, Kuhnert, Maren, Diederich, Wibke E., Heine, Andreas, Neumann, Lars, Atmanene, Cedric, Roecklin, Dominique, Vivat-Hannah, Valérie, Renaud, Jean-Paul, Meinecke, Robert, Schlinck, Nina, Sitte, Astrid, Popp, Franziska, Zeeb, Markus, Klebe, Gerhard

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Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery von Behnen, Jürgen, Köster, Helene, Neudert, Gerd, Craan, Tobias, Heine, Andreas, Klebe, Gerhard

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Crystallographic fragment screening: challenges, opportunities, lessons learned von Heine, Andreas, Radeva, Nedyalka, Schiebel, Johannes, Park, Ahyoung, Köster, Helene, Ühlein, Monika, Sparta, Karine, Weiss, Manfred, Mueller, Uwe, Klebe, Gerhard

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Chamäleon‐artige Bindungsmodi in der Leitstrukturoptimierung: wechselnde Bindungsgeometrien bei Aspartylprotease‐Inhibitoren von Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.

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Strukturbasiertes Design von Hemmstoffen der Aspartylprotease Endothiapepsin mittels dynamischer kombinatorischer Chemie von Mondal, Milon, Radeva, Nedyalka, Köster, Helene, Park, Ahyoung, Potamitis, Constantinos, Zervou, Maria, Klebe, Gerhard, Hirsch, Anna K. H.

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Chamäleon-artige Bindungsmodi in der Leitstrukturoptimierung: wechselnde Bindungsgeometrien bei Aspartylprotease-Inhibitoren von Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.

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Strukturbasiertes Design von Hemmstoffen der Aspartylprotease Endothiapepsin mittels dynamischer kombinatorischer Chemie von Mondal, Milon, Radeva, Nedyalka, Köster, Helene, Park, Ahyoung, Potamitis, Constantinos, Zervou, Maria, Klebe, Gerhard, Hirsch, Anna K. H.

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Endothiapepsin und Proteinkinase A: Komplexstrukturen mit neuartigen Inhibitoren, Durchmustern einer Fragmentbibliothek sowie Inhibitordesign ausgehend von einer Sonde von Köster, Helene

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Can we decode phonetic features in inner speech using surface electromyography? von Nalborczyk, Ladislas, Grandchamp, Romain, Koster, Ernst H W, Perrone-Bertolotti, Marcela, Lœvenbruck, Hélène

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Atherosclerosis in Abdominal Aortic Aneurysms: A Causal Event or a Process Running in Parallel? The Tromsø Study von Johnsen, Stein Harald, Forsdahl, Signe Helene, Singh, Kulbir, Jacobsen, Bjarne Koster

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What is a “Good Life”: Protocol for a qualitative study to explore the viewpoint of older persons von Michel, Hervé, Prévôt-Huille, Hélène, Koster, Raphaël, Ecarnot, Fiona, Grange, Zoé, Sanchez, Stéphane

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Influence of macroscopic shear loading on the growth of an interfacial crack initiated from a ceramic blister processed by laser shock von Sapardanis, Hélène, Maurel, Vincent, Köster, Alain, Duvinage, Steve, Borit, François, Guipont, Vincent

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Vaccination Did Not Prevent Severe Coronavirus Disease 2019 in an Outbreak Among Older Residents of a Nursing Home, B.1.617.2 Variant, July 2021 von Buskermolen, Maaike, Molthof, Irene, Voeten, Helene A. C. M., van Twillert, Joanna, Schriek, Annette, Flach, Carla, Dijkers, Marlies, Smit, Pieter W., Koster, Tirsah, Fanoy, Ewout B, Whelan, Jane, Tjon-A-Tsien, Aimée

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Dissociating facial electromyographic correlates of visual and verbal induced rumination von Nalborczyk, Ladislas, Banjac, Sonja, Baeyens, Céline, Grandchamp, Romain, Koster, Ernst H.W., Perrone-Bertolotti, Marcela, Lœvenbruck, Hélène

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Incident type 2 diabetes attributable to suboptimal diet in 184 countries von O’Hearn, Meghan, Lara-Castor, Laura, Cudhea, Frederick, Miller, Victoria, Reedy, Julia, Shi, Peilin, Zhang, Jianyi, Wong, John B., Economos, Christina D., Micha, Renata, Mozaffarian, Dariush

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Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems von Dijk, Frederike, Veenstra, Veronique L., Soer, Eline C., Dings, Mark P. G., Zhao, Lan, Halfwerk, Johannes B., Hooijer, Gerrit K., Damhofer, Helene, Marzano, Marco, Steins, Anne, Waasdorp, Cynthia, Busch, Olivier R., Besselink, Marc G., Tol, Johanna A., Welling, Lieke, van Rijssen, Lennart B., Klompmaker, Sjors, Wilmink, Hanneke W., van Laarhoven, Hanneke W., Medema, Jan Paul, Vermeulen, Louis, van Hooff , Sander R., Koster, Jan, Verheij, Joanne, van de Vijver, Marc J., Wang, Xin, Bijlsma, Maarten F.

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Orofacial electromyographic correlates of induced verbal rumination von Nalborczyk, Ladislas, Perrone-Bertolotti, Marcela, Baeyens, Céline, Grandchamp, Romain, Polosan, Mircea, Spinelli, Elsa, Koster, Ernst H.W., Lœvenbruck, Hélène

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