Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 von Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas von Sneeringer, Christopher J., Scott, Margaret Porter, Kuntz, Kevin W., Knutson, Sarah K., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Wells, James A.

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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma von Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse S, Kuntz, Kevin K, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike

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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma von Knutson, Sarah K, Kawano, Satoshi, Minoshima, Yukinori, Warholic, Natalie M, Huang, Kuan-Chun, Xiao, Yonghong, Kadowaki, Tadashi, Uesugi, Mai, Kuznetsov, Galina, Kumar, Namita, Wigle, Tim J, Klaus, Christine R, Allain, Christina J, Raimondi, Alejandra, Waters, Nigel J, Smith, Jesse J, Porter-Scott, Margaret, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A, Richon, Victoria M, Uenaka, Toshimitsu, Pollock, Roy M, Kuntz, Kevin W, Yokoi, Akira, Keilhack, Heike

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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models von Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R, Feldman, Igor, Knutson, Sarah K, Kuplast-Barr, Kristy, Roche, Maria, Campbell, John, Ho, Peter, Copeland, Robert A, Chesworth, Richard, Smith, Jesse J, Keilhack, Heike, Ribich, Scott A

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells von Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W

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Loss of BAP1 function leads to EZH2-dependent transformation von LaFave, Lindsay M, Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D, Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K, Campbell, John E, Blum, Gil, Shi, Xinxu, Doud, Emma H, Krivtsov, Andrei V, Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S, Thomas, Paul M, Kelleher, Neil L, Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A, Levine, Ross L

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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat von Kuntz, Kevin W, Campbell, John E, Keilhack, Heike, Pollock, Roy M, Knutson, Sarah K, Porter-Scott, Margaret, Richon, Victoria M, Sneeringer, Chris J, Wigle, Tim J, Allain, Christina J, Majer, Christina R, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard

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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas von Knutson, Sarah K, Warholic, Natalie M, Johnston, L Danielle, Klaus, Christine R, Wigle, Tim J, Iwanowicz, Dorothy, Littlefield, Bruce A, Porter-Scott, Margaret, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Pollock, Roy M, Kuntz, Kevin W, Raimondi, Alejandra, Keilhack, Heike

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Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability von Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.

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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL von Brach, Dorothy, Johnston-Blackwell, Danielle, Drew, Allison, Lingaraj, Trupti, Motwani, Vinny, Warholic, Natalie M, Feldman, Igor, Plescia, Christopher, Smith, Jesse J, Copeland, Robert A, Keilhack, Heike, Chan-Penebre, Elayne, Knutson, Sarah K, Ribich, Scott A, Raimondi, Alejandra, Thomenius, Michael J

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A687V EZH2 is a gain-of-function mutation found in lymphoma patients von Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.

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Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks von Knutson, Sarah K, Chyla, Brenda J, Amann, Joseph M, Bhaskara, Srividya, Huppert, Stacey S, Hiebert, Scott W

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Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat von Razidlo, David F, Whitney, Tiffany J, Casper, Michelle E, McGee-Lawrence, Meghan E, Stensgard, Bridget A, Li, Xiaodong, Secreto, Frank J, Knutson, Sarah K, Hiebert, Scott W, Westendorf, Jennifer J

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Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control von Bhaskara, Srividya, Chyla, Brenda J., Amann, Joseph M., Knutson, Sarah K., Cortez, David, Sun, Zu-Wen, Hiebert, Scott W.

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Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteins von Hsieh, Meng-Hsiung, Wei, Yonglong, Li, Lin, Nguyen, Liem H, Lin, Yu-Hsuan, Yong, Jung M, Sun, Xuxu, Wang, Xun, Luo, Xin, Knutson, Sarah K, Bracken, Christina, Daley, George Q, Powers, John T, Zhu, Hao

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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states von Wigle, Tim J., Knutson, Sarah K., Jin, Lei, Kuntz, Kevin W., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Scott, Margaret Porter

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Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma von Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse J, Kuntz, Kevin W, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike

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Proceedings of the inaugural Dark Genome Symposium: November 2022 von Boeke, Jef D, Burns, Kathleen H, Chiappinelli, Katherine B, Classon, Marie, Coffin, John M, DeCarvalho, Daniel D, Dukes, Joseph D, Greenbaum, Benjamin, Kassiotis, George, Knutson, Sarah K, Levine, Arnold J, Nath, Avindra, Papa, Sophie, Rios, Daniel, Sedivy, John, Ting, David T

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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity von Campbell, John E, Kuntz, Kevin W, Knutson, Sarah K, Warholic, Natalie M, Keilhack, Heike, Wigle, Tim J, Raimondi, Alejandra, Klaus, Christine R, Rioux, Nathalie, Yokoi, Akira, Kawano, Satoshi, Minoshima, Yukinori, Choi, Hyeong-Wook, Porter Scott, Margaret, Waters, Nigel J, Smith, Jesse J, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A

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