Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer von Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael

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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis von Santamaria, Anna, Neef, Rüdiger, Eberspächer, Uwe, Eis, Knut, Husemann, Manfred, Mumberg, Dominik, Prechtl, Stefan, Schulze, Volker, Siemeister, Gerhard, Wortmann, Lars, Barr, Francis A, Nigg, Erich A

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Identification of Small Molecules that Modulate Mutant p53 Condensation von Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction von Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

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A Modular Approach to Structurally Diverse Bidentate Chelate Ligands for Transition Metal Catalysis von Kranich, Remo, Eis, Knut, Geis, Oliver, Mühle, Stefan, Bats, Jan W., Schmalz, Hans-Günther

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5 von Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea

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BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity von Santag, Susann, Siegel, Franziska, Wengner, Antje M, Lange, Claudia, Bömer, Ulf, Eis, Knut, Pühler, Florian, Lienau, Philip, Bergemann, Linda, Michels, Martin, von Nussbaum, Franz, Mumberg, Dominik, Petersen, Kirstin

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Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069 von Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling von Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin

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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies von Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard

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Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069” von Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists von Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouché, Léa, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Pütter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Abstract 1470: Preclinical activity of the first reversible, potent and selective inhibitor of EGFR exon 20 insertions von Siegel, Franziska, Siegel, Stephan, Graham, Keith, Kaplan, Bethany, Petersen, Kirstin, Boemer, Ulf, Eberspaecher, Uwe, Korr, Daniel, Moenning, Ursula, Suelzle, Detlev, Schroeder, Jens, Prinz, Florian, Zitzmann-Kolbe, Sabine, Karsli-Uzunbas, Gizem, Lewis, Timothy, Hermsen, Mario, Cherniack, Andrew, von Nussbaum, Franz, Eis, Knut, Meyerson, Matthew, Greulich, Heidi

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Abstract 5880: Small-molecule modulators of PDE3/SLFN12 to kill cancer cells von Lewis, Timothy A., Waal, Luc de, Wu, Xiaoyun, Ellerman, Manuel, Kopitz, Charlotte, Wengner, Antje, Eis, Knut, Lange, Martin, Tersteegen, Adrian, Lienau, Philip, Greulich, Heidi, Meyerson, Matthew

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Abstract 2: Discovery of BAY 2402234 by phenotypic screening: A human Dihydroorotate Dehydrogenase (DHODH) inhibitor in clinical trials for the treatment of myeloid malignancies von Gradl, Stefan N., Mueller, Thomas, Ferrara, Steven, Sheikh, Sherif El, Janzer, Andreas, Zhou, Han-Jie, Friberg, Anders, Guenther, Judith, Schaefer, Martina, Stellfeld, Timo, Eis, Knut, Kroeber, Michael, Nguyen, Duy, Merz, Claudia, Niehues, Michael, Stoeckigt, Detlef, Christian, Sven, Zimmermann, Katja, Lejeune, Pascal, Bruening, Michael, Meyer, Hanna, Puetter, Vera, Scadden, David T., Sykes, David B., Seidel, Henrik, Eheim, Ashley, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus

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Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C (ChemMedChem 10/2020) von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C (ChemMedChem 10/2020) von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C, Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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