The history and future of targeting cyclin-dependent kinases in cancer therapy von Asghar, Uzma, Witkiewicz, Agnieszka K., Turner, Nicholas C., Knudsen, Erik S.

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Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities von Franco, Jorge, Balaji, Uthra, Freinkman, Elizaveta, Witkiewicz, Agnieszka K., Knudsen, Erik S.

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The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies von Knudsen, Erik S., Witkiewicz, Agnieszka K.

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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets von Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.

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Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions von Witkiewicz, Agnieszka K, Knudsen, Erik S

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Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers von Knudsen, Erik S, Vail, Paris, Balaji, Uthra, Ngo, Hoai, Botros, Ihab W, Makarov, Vladimir, Riaz, Nadeem, Balachandran, Vinod, Leach, Steven, Thompson, Debrah M, Chan, Timothy A, Witkiewicz, Agnieszka K

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MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies von Baek, GuemHee, Tse, Yan F., Hu, Zeping, Cox, Derek, Buboltz, Noah, McCue, Peter, Yeo, Charles J., White, Michael A., DeBerardinis, Ralph J., Knudsen, Erik S., Witkiewicz, Agnieszka K.

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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer von Thangavel, Chellappagounder, Dean, Jeffry L, Ertel, Adam, Knudsen, Karen E, Aldaz, C Marcelo, Witkiewicz, Agnieszka K, Clarke, Robert, Knudsen, Erik S

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Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer von Jansen, Valerie M, Bhola, Neil E, Bauer, Joshua A, Formisano, Luigi, Lee, Kyung-Min, Hutchinson, Katherine E, Witkiewicz, Agnieszka K, Moore, Preston D, Estrada, Mónica Valéria, Sánchez, Violeta, Ericsson, Paula G, Sanders, Melinda E, Pohlmann, Paula R, Pishvaian, Michael J, Riddle, David A, Dugger, Teresa C, Wei, Wenyi, Knudsen, Erik S, Arteaga, Carlos L

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism von Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

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Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer von Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Conway, William, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.

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The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression von Sharma, Ankur, Yeow, Wen-Shuz, Ertel, Adam, Coleman, Ilsa, Clegg, Nigel, Thangavel, Chellappagounder, Morrissey, Colm, Zhang, Xiaotun, Comstock, Clay E S, Witkiewicz, Agnieszka K, Gomella, Leonard, Knudsen, Erik S, Nelson, Peter S, Knudsen, Karen E

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Targeting the RB-pathway in Cancer Therapy von KNUDSEN, Erik S, WANG, Jean Y. J

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Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine von Knudsen, Erik S, O’Reilly, Eileen M, Brody, Jonathan R, Witkiewicz, Agnieszka K

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Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors von Dean, Jeffry L., McClendon, A. Kathleen, Hickey, Theresa E., Butler, Lisa M., Tilley, Wayne D., Witkiewicz, Agnieszka K., Knudsen, Erik S.

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Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer von Witkiewicz, Agnieszka K., Chung, Sejin, Brough, Rachel, Vail, Paris, Franco, Jorge, Lord, Christopher J., Knudsen, Erik S.

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Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via Metabolo-Genomic... von Martinez-Outschoorn, Ubaldo E., Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S., Howell, Anthony, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P

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Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease von Hutcheson, Jack, Balaji, Uthra, Porembka, Matthew R, Wachsmann, Megan B, McCue, Peter A, Knudsen, Erik S, Witkiewicz, Agnieszka K

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Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy von Knudsen, Erik S, Pruitt, Steven C, Hershberger, Pamela A, Witkiewicz, Agnieszka K, Goodrich, David W

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The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis von YUNXIA FAN, BOIVIN, Gregory P, KNUDSEN, Erik S, NEBERT, Daniel W, YING XIA, PUGA, Alvaro

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