Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954 von PLUMB, Jane A, BILSLAND, Alan, KAKANI, Rania, ZHAO, Jiangqin, GLASSPOOL, Rosalind M, KNOX, Richard J, EVANS, T. R, KEITH, W. Nicol

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Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase von Bilsland, Alan E, Anderson, Claire J, Fletcher-Monaghan, Aileen J, McGregor, Fiona, Jeffry Evans, T R, Ganly, Ian, Knox, Richard J, Plumb, Jane A, Nicol Keith, W

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Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs von Burke, Philip J., Wong, Lai Chun, Jenkins, Terence C., Knox, Richard J., Meikle, Ian T., Stanforth, Stephen P.

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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs von LONGQIN HU, XINGHUA WU, KNOX, Richard J, WILKINSON, Shane R, JIYE HAN, LIN CHEN, VASS, Simon O, BROWNE, Patrick, HALL, Belinda S, BOT, Christopher, GOBALAKRISHNAPILLAI, Vithurshaa, SEARLE, Peter F

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Functionalized Cyclopentadienyl Titanium Organometallic Compounds as New Antitumor Drugs von Allen, Olivia R, Croll, Lorna, Gott, Andrew L, Knox, Richard J, McGowan, Patrick C

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Nitroreductase from Bacillus licheniformis: A stable enzyme for prodrug activation von Emptage, Caroline D., Knox, Richard J., Danson, Michael J., Hough, David W.

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Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs von Allen, Olivia R, Knox, Richard J, McGowan, Patrick C

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The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1- a]isoquinoline N-oxides and related heterocycles as potential bioreducib... von Burke, Philip J., Chun Wong, Lai, Jenkins, Terence C., Knox, Richard J., Stanforth, Stephen P.

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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations von Jaberipour, Mansooreh, Vass, Simon O., Guise, Christopher P., Grove, Jane I., Knox, Richard J., Hu, Longqin, Hyde, Eva I., Searle, Peter F.

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Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs von Allen, Olivia R, Gott, Andrew L, Hartley, John A, Hartley, Janet M, Knox, Richard J, McGowan, Patrick C

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Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. coli Nitroreductase Activation von JIANG, Yongying, HAN, Jiye, YU, Chengzhi, VASS, Simon O., SEARLE, Peter F., BROWNE, Patrick, KNOX, Richard J., HU, Longqin

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Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture von Li, Zhuorong, Han, Jiye, Jiang, Yongying, Browne, Patrick, Knox, Richard J, Hu, Longqin

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Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications von Knox, Richard J, Chen, Shiuan

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Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy von Hu, Longqin, Yu, Chengzhi, Jiang, Yongying, Han, Jiye, Li, Zhuorong, Browne, Patrick, Race, Paul R, Knox, Richard J, Searle, Peter F, Hyde, Eva I

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KW-2149 (7- N-[2-[γ- l-glutamylamino]ethyldithio-ethyl] mitomycin C): DNA Interactions and Drug Uptake Following Serum Activation von McAdam, Simon R, Knox, Richard J, Hartley, John A, Masters, John R.W

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Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. c oli Nitroreductase Activation von Jiang, Yongying, Han, Jiye, Yu, Chengzhi, Vass, Simon O, Searle, Peter F, Browne, Patrick, Knox, Richard J, Hu, Longqin

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Developments with targeted enzymes in cancer therapy von Bagshawe, Kenneth D, Sharma, Surinder K, Burke, Philip J, Melton, Roger G, Knox, Richard J

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Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species von Bailey, Susan M., Lewis, Alex D., Patterson, Laurence H., Fisher, Geoff R., Knox, Richard J., Workman, Paul

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Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in t... von KNOX, R. J, FRIEDLOS, F, LYDALL, D. A, ROBERTS, J. J

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Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme von Mauger, Anthony B, Burke, Philip J, Somani, Hanif H, Friedlos, Frank, Knox, Richard J

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