Extended-spectrum and inhibitor-resistant TEM-type β-lactamases : mutations, specificity, and three-dimensional structure von KNOX, J. R

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Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2 : A novel co-substrate-mediated antitumor prodrug therapy von KNOX, R. J, JENKINS, T. C, HOBBS, S. M, SHIUAN CHEN, MELTON, R. G, BURKE, P. J

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A Thallium-Sensitive, Fluorescence-Based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian Cells von Weaver, C. David, Harden, David, Dworetzky, Steven I., Robertson, Barbara, Knox, Ronald J.

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Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor von Jamieson, D, Tung, A T Y, Knox, R J, Boddy, A V

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Criterion-related validity of the cultural web when assessing safety culture von Cooper, M.D., Collins, M., Bernard, R., Schwann, S., Knox, R.J.

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Vancomycin Resistance: Structure of D-Alanine:D-Alanine Ligase at 2.3 Å Resolution von Fan, Chang, Moews, Paul C., Walsh, Christopher T., Knox, James R.

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Evolution of an Enzyme Activity: Crystallographic Structure at 2- Å Resolution of Cephalosporinase from the ampC Gene of Enterobacter cloacae P99 and Comparison with a Class A Peni... von Lobkovsky, Emil, Moews, Paul C., Liu, Hansong, Zhao, Haiching, Frere, Jean-Marie, Knox, James R.

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Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954 von Bridgewater, J.A., Springer, C.J., Knox, R.J., Minton, N.P., Michael, N.P., Collins, M.K.

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The Bystander Effect of the Nitroreductase/CB 1954 Enzyme/Prodrug System Is Due to a Cell-Permeable Metabolite von Bridgewater, J. A., Knox, R. J., Pitts, J. D., Collins, M. K., Springer, C. J.

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Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion von Jonas, Elizabeth A., Knox, Ronald J., Smith, T. Caitlin M., Wayne, Nancy L., Connor, John A., Kaczmarek, Leonard K.

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Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway von Fryer, Hugh J. L., Wolf, Daniel H., Knox, Ronald J., Strittmatter, Stephen M., Pennica, Diane, O'Leary, Rhona M., Russell, David S., Kalb, Robert G.

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Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro von Fryer, Hugh J. L., Knox, Ronald J., Strittmatter, Stephen M., Kalb, Robert

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Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling von HULETSKY, A, KNOX, J. R, LEVESQUE, R. C

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β-Lactamase of Bacillus licheniformis 749/C at 2 Å resolution von Moews, Paul C., Knox, James R., Dideberg, Otto, Charlier, Paulette, Frère, Jean-Marie

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Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase von Anlezark, G.M., Melton, R.G., Sherwood, R.F., Wilson, W.R., Denny, W.A., Palmer, B.D., Knox, R.J., Friedlos, F., Williams, A.

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Inhibition of the SHV-1 β-Lactamase by Sulfones:  Crystallographic Observation of Two Reaction Intermediates with Tazobactam von Kuzin, Alexandre P, Nukaga, Michiyoshi, Nukaga, Yasuko, Hujer, Andrea, Bonomo, Robert A, Knox, James R

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Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in t... von KNOX, R. J, FRIEDLOS, F, LYDALL, D. A, ROBERTS, J. J

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Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme von Mauger, Anthony B, Burke, Philip J, Somani, Hanif H, Friedlos, Frank, Knox, Richard J

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The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT) von KNOX, R. J, FRIEDLOS, F, BOLAND, M. P

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Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954 von PLUMB, Jane A, BILSLAND, Alan, KAKANI, Rania, ZHAO, Jiangqin, GLASSPOOL, Rosalind M, KNOX, Richard J, EVANS, T. R, KEITH, W. Nicol

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