Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells von Alimova, Irina, Birks, Diane K, Harris, Peter S, Knipstein, Jeffrey A, Venkataraman, Sujatha, Marquez, Victor E, Foreman, Nicholas K, Vibhakar, Rajeev

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Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells von Venkataraman, Sujatha, Alimova, Irina, Tello, Tiffany, Harris, Peter S., Knipstein, Jeffrey A., Donson, Andrew M., Foreman, Nicholas K., Liu, Arthur K., Vibhakar, Rajeev

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Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells von Knipstein, Jeffrey A, Birks, Diane K, Donson, Andrew M, Alimova, Irina, Foreman, Nicholas K, Vibhakar, Rajeev

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Sweet syndrome in an infant with chronic granulomatous disease von Knipstein, Jeffrey A, Ambruso, Daniel R

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Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells von Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Donson, Andrew M, Knipstein, Jeffrey, Dubuc, Adrian, Taylor, Michael D, Handler, Michael H, Foreman, Nicholas K, Vibhakar, Rajeev

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IMG-10. MAGNETIC RESONANCE FUNCTIONAL IMAGING BIOMARKER FOR DISTINGUISHING HIGH GRADE FROM LOW GRADE PEDIATRIC BRAIN TUMORS von Kelly, Teresa Gross, Schmainda, Kathleen, Prah, Melissa, Jeffrey, Knipstein, Maheshwari, Mohit, Lew, Sean, Baker, Marjorie Bessette

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NURS-11. IMPACT OF A CENTRAL NERVOUS SYSTEM (CNS) TUMOR PATIENT AND FAMILY EVENT von Belongia, Meghan, Novak, Suzanne, Knipstein, Jeffrey

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The impact of using time critical intervention‐based dispatch thresholds on lowering lights and siren use to EMS 911 incidents von Jarvis, Jeffrey L., Johns, Danny, Jarvis, Sydney E., Knipstein, Mike, Ratcliff, Taylor

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Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency von Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C., Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, Sambira Nahum, Lauren C, Ercan, Ayse B., Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S., George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B., Mordechai, Oz, Bowers, Daniel C., Laetsch, Theodore W., Lossos, Alexander, Blumenthal, Deborah T., Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M., Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E., Zapotocky, Michal, Hansford, Jordan R., Maris, John M., Dirks, Peter, Taylor, Michael D., Kulkarni, Abhaya V., Shroff, Manohar, Tsang, Derek S., Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E., Ohashi, Pamela S., Hawkins, Cynthia, Pugh, Trevor J., Bouffet, Eric, Tabori, Uri

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Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance von Durno, Carol, Ercan, Ayse Bahar, Bianchi, Vanessa, Edwards, Melissa, Aronson, Melyssa, Galati, Melissa, Atenafu, Eshetu G., Abebe-Campino, Gadi, Al-Battashi, Abeer, Alharbi, Musa, Azad, Vahid Fallah, Baris, Hagit N., Basel, Donald, Bedgood, Raymond, Bendel, Anne, Ben-Shachar, Shay, Blumenthal, Deborah T., Blundell, Maude, Bornhorst, Miriam, Bronsema, Annika, Cairney, Elizabeth, Rhode, Sara, Caspi, Shani, Chamdin, Aghiad, Chiaravalli, Stefano, Constantini, Shlomi, Crooks, Bruce, Das, Anirban, Dvir, Rina, Farah, Roula, Foulkes, William D., Frenkel, Zehavit, Gallinger, Bailey, Gardner, Sharon, Gass, David, Ghalibafian, Mithra, Gilpin, Catherine, Goldberg, Yael, Goudie, Catherine, Hamid, Syed Ahmer, Hampel, Heather, Hansford, Jordan R., Harlos, Craig, Hijiya, Nobuko, Hsu, Saunders, Kamihara, Junne, Kebudi, Rejin, Knipstein, Jeffrey, Koschmann, Carl, Kratz, Christian, Larouche, Valerie, Lassaletta, Alvaro, Lindhorst, Scott, Ling, Simon C., Link, Michael P., De Mola, Rebecca Loret, Luiten, Rebecca, Lurye, Michal, Maciaszek, Jamie L., MagimairajanIssai, Vanan, Maher, Ossama M., Massimino, Maura, McGee, Rose B., Mushtaq, Naureen, Mason, Gary, Newmark, Monica, Nicholas, Garth, Nichols, Kim E., Nicolaides, Theodore, Opocher, Enrico, Osborn, Michael, Oshrine, Benjamin, Pearlman, Rachel, Pettee, Daniel, Rapp, Jan, Rashid, Mohsin, Reddy, Alyssa, Reichman, Lara, Remke, Marc, Robbins, Gabriel, Roy, Sumita, Sabel, Magnus, Samuel, David, Scheers, Isabelle, Schneider, Kami Wolfe, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Swallow, Carol, Taylor, Leslie, Thomas, Gregory, Toledano, Helen, Tomboc, Patrick, Van Damme, An, Winer, Ira, Yalon, Michal, Yen, Lee Yi, Zapotocky, Michal, Zelcer, Shayna, Ziegler, David S.

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CTIM-19. A PHASE 1, SAFETY LEAD-IN AND RANDOMIZED, OPEN-LABEL, PERIOPERATIVE STUDY OF VORASIDENIB COMBINED WITH PEMBROLIZUMAB IN RECURRENT OR PROGRESSIVE ENHANCING IDH-1 MUTANT GLI... von Wen, Patrick, de la Fuente, Macarena, Kumthekar, Priya, Peters, Katherine, Clarke, Jennifer, de Groot, John, Arrillaga-Romany, Isabel, Puduvalli, Vinay, Mellinghoff, Ingo, Chong, Robert, Jain, Payal, Barboux, Valentine, Chisamore, Michael, Abshire, Michelle, Mahboub-Johnson, Paria, Hassan, Islam, Knipstein, Jeffrey, Cloughesy, Timothy

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Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway von Idso, John M., Lao, Shunhua, Schloemer, Nathan J., Knipstein, Jeffrey, Burns, Robert, Thakar, Monica S., Malarkannan, Subramaniam

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TargetableBRAFandRAF1Alterations in Advanced Pediatric Cancers von Rankin, Andrew, Johnson, Adrienne, Roos, Alison, Kannan, Geoffrey, Knipstein, Jeffrey, Britt, Nicholas, Rosenzweig, Mark, Haberberger, James, Pavlick, Dean, Severson, Eric, Vergilio, Jo-Anne, Squillace, Rachel, Erlich, Rachel, Sathyan, Pratheesh, Cramer, Stuart, Kram, David, Ross, Jeffrey, Miller, Vince, Reddy, Prasanth, Alexander, Brian, Ali, Siraj M., Ramkissoon, Shakti

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Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset von Chung, Jiil, Negm, Logine, Bianchi, Vanessa, Stengs, Lucie, Das, Anirban, Liu, Zhihui Amy, Sudhaman, Sumedha, Aronson, Melyssa, Brunga, Ledia, Edwards, Melissa, Forster, Victoria, Komosa, Martin, Davidson, Scott, Lees, Jodi, Tomboc, Patrick, Samuel, David, Farah, Roula, Bendel, Anne, Knipstein, Jeffrey, Schneider, Kami Wolfe, Reschke, Agnes, Zelcer, Shayna, Zorzi, Alexandra, McWilliams, Robert, Foulkes, William D, Bedgood, Raymond, Peterson, Lindsay, Rhode, Sara, Van Damme, An, Scheers, Isabelle, Gardner, Sharon, Robbins, Gabriel, Vanan, Magimairajan Issai, Meyn, M Stephen, Auer, Rebecca, Leach, Brandie, Burke, Carol, Villani, Anita, Malkin, David, Bouffet, Eric, Huang, Annie, Taylor, Michael D, Durno, Carol, Shlien, Adam, Hawkins, Cynthia, Getz, Gad, Maruvka, Yosef E, Tabori, Uri

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Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study von Erker, Craig, Mynarek, Martin, Bailey, Simon, Mazewski, Claire M, Baroni, Lorena, Massimino, Maura, Hukin, Juliette, Aguilera, Dolly, Cappellano, Andrea M, Ramaswamy, Vijay, Lassaletta, Alvaro, Perreault, Sébastien, Kline, Cassie N, Rajagopal, Revathi, Michaiel, George, Zapotocky, Michal, Santa-Maria Lopez, Vicente, La Madrid, Andres Morales, Cacciotti, Chantel, Sandler, Eric S, Hoffman, Lindsey M, Klawinski, Darren, Khan, Sara, Salloum, Ralph, Hoppmann, Anna L, Larouche, Valérie, Dorris, Kathleen, Toledano, Helen, Gilheeney, Stephen W, Abdelbaki, Mohamed S, Wilson, Beverly, Tsang, Derek S, Knipstein, Jeffrey, Oren, Michal Yalon, Shah, Shafqat, Murray, Jeffrey C, Ginn, Kevin F, Wang, Zhihong J, Fleischhack, Gudrun, Obrecht, Denise, Tonn, Svenja, Harrod, Virginia L, Matheson, Kara, Crooks, Bruce, Strother, Douglas R, Cohen, Kenneth J, Hansford, Jordan R, Mueller, Sabine, Margol, Ashley, Gajjar, Amar, Dhall, Girish, Finlay, Jonathan L, Northcott, Paul A, Rutkowski, Stefan, Clifford, Steven C, Robinson, Giles, Bouffet, Eric, Lafay-Cousin, Lucie

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CTIM-14. PHASE 1 SAFETY LEAD-IN AND RANDOMIZED OPEN-LABEL PERIOPERATIVE STUDY OF VORASIDENIB COMBINED WITH PEMBROLIZUMAB IN RECURRENT OR PROGRESSIVE ENHANCING IDH1-MUTANT ASTROCYTO... von Wen, Patrick, Peters, Katherine, de la Fuente, Macarena, Mellinghoff, Ingo, Arrillaga-Romany, Isabel, Kumthekar, Priya, Clarke, Jennifer, Puduvalli, Vinay, de Groot, John, Zhang, Xiangmin, Chisamore, Michael, Abshire, Michelle, Mahboub, Paria, Hassan, Islam, Knipstein, Jeffrey, Cloughesy, Timothy

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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study von Ercan, Ayse Bahar, Aronson, Melyssa, Chang, Yuan, Liu, Zhihui Amy, Negm, Logine, Edwards, Melissa, Chung, Jiil, Reschke, Agnes, Lion, Alex, Ahmad, Alia, Lassaletta, Alvaro, Al-Darraji, Amir F, Shah, Amish C, Van Damme, An, Bendel, Anne, Rashid, Aqeela, Margol, Ashley S, Kelly, Bethany L, Heald, Brandie, Lemieux-Anglin, Brianna, Crooks, Bruce, Koschmann, Carl, Gilpin, Catherine, Gass, David, Samuel, David, Ziegler, David S, Blumenthal, Deborah T, Kuo, Dennis John, Hamideh, Dima, Basel, Donald, Stearns, Duncan, Opocher, Enrico, Toledano, Helen, Winer, Ira, Fedorakova, Ivana, Su, Jack M, Vengoechea, Jaime, Sterba, Jaroslav, Knipstein, Jeffrey, Hansford, Jordan R, Bhatia, Kanika, Minhas, Khurram, Nichols, Kim E, Cole, Kristina A, Penney, Lynette, Hjort, Magnus Aasved, Sabel, Magnus, Murray, Matthew J, Miller, Matthew, Blundell, Maude L, Massimino, Maura, Al-Hussaini, Maysa, Comito, Melanie A, Osborn, Michael, Link, Michael P, Zapotocky, Michal, Ghalibafian, Mithra, Mushtaq, Naureen, Hijiya, Nobuko, Fuentes-Bolanos, Noemi, Ahmad, Olfat, Chamdine, Omar, Pichurin, Pavel N, Nyman, Per, Auer, Rebecca C, Sukumaran, Reghu K, Kebudi, Rejin, Dvir, Rina, Raphael, Robert, Elhasid, Ronit, Chami, Rose, Noss, Ryan, Tanaka, Ryuma, Raskin, Salmo, Sen, Santanu, Lindhorst, Scott, Caspi, Shani, Riaz, Shazia, Constantini, Shlomi, Albert, Sophie, Chaleff, Stanley, Chiaravalli, Stefano, Roy, Sumita, Cahn, Suzanne, Hamid, Syed Ahmer, Ghafoor, Tariq, Imam, Uzma, Larouche, Valerie, Magimairajan Issai, Vanan, Foulkes, William D, Lee, Yi Yen, Nathan, Paul C, Maruvka, Yosef E, Greer, Mary-Louise C, Durno, Carol, Shlien, Adam, Malkin, David, Hawkins, Cynthia, Das, Anirban, Tabori, Uri

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Targetable BRAF and RAF1 Alterations in Advanced Pediatric Cancers von Rankin, Andrew, Johnson, Adrienne, Roos, Alison, Kannan, Geoffrey, Knipstein, Jeffrey, Britt, Nicholas, Rosenzweig, Mark, Haberberger, James, Pavlick, Dean, Severson, Eric, Vergilio, Jo‐Anne, Squillace, Rachel, Erlich, Rachel, Sathyan, Pratheesh, Cramer, Stuart, Kram, David, Ross, Jeffrey, Miller, Vince, Reddy, Prasanth, Alexander, Brian, Ali, Siraj M., Ramkissoon, Shakti

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Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient von Amin, Ruchi, Berdan, Elizabeth, Knipstein, Jeffrey, Jarzembowski, Jason, Siddiqui, Sabina

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HGG-05. GALLIUM MALTOLATE AS TREATMENT IN PEDIATRIC GLIOMA von Molino, Salvatore, Al-Gizawiy, Mona, Knipstein, Jeffrey, Schmainda, Kathleen, Chitambar, Christopher

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