WNT signaling in bone homeostasis and disease: from human mutations to treatments von Baron, Roland, Kneissel, Michaela

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Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice von Kramer, Ina, Loots, Gabriela G, Studer, Anne, Keller, Hansjoerg, Kneissel, Michaela

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Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis von Kramer, Ina, Halleux, Christine, Keller, Hansjoerg, Pegurri, Marco, Gooi, Jonathan H., Weber, Patricia Brander, Feng, Jian Q., Bonewald, Lynda F., Kneissel, Michaela

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Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma von McDonald, Michelle M., Reagan, Michaela R., Youlten, Scott E., Mohanty, Sindhu T., Seckinger, Anja, Terry, Rachael L., Pettitt, Jessica A., Simic, Marija K., Cheng, Tegan L., Morse, Alyson, Le, Lawrence M.T., Abi-Hanna, David, Kramer, Ina, Falank, Carolyne, Fairfield, Heather, Ghobrial, Irene M., Baldock, Paul A., Little, David G., Kneissel, Michaela, Vanderkerken, Karin, Bassett, J.H.Duncan, Williams, Graham R., Oyajobi, Babatunde O., Hose, Dirk, Phan, Tri G., Croucher, Peter I.

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Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels von Chang, Ming-Kang, Kramer, Ina, Huber, Thomas, Kinzel, Bernd, Guth-Gundel, Sabine, Leupin, Olivier, Kneissel, Michaela

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Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice von Yang, Haisheng, Büttner, Alexander, Albiol, Laia, Julien, Catherine, Thiele, Tobias, Figge, Christine, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Checa, Sara, Willie, Bettina M.

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Anti‐Sclerostin Antibody Treatment in a Rat Model of Progressive Renal Osteodystrophy von Moe, Sharon M, Chen, Neal X, Newman, Christopher L, Organ, Jason M, Kneissel, Michaela, Kramer, Ina, Gattone, Vincent H, Allen, Matthew R

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Mechanical Load Increases in Bone Formation via a Sclerostin‐Independent Pathway von Morse, Alyson, McDonald, Michelle Maree, Kelly, Natalie H, Melville, Katherine M, Schindeler, Aaron, Kramer, Ina, Kneissel, Michaela, van der Meulen, Marjolein CH, Little, David Graham

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Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function von Leupin, Olivier, Piters, Elke, Halleux, Christine, Hu, Shouih, Kramer, Ina, Morvan, Frederic, Bouwmeester, Tewis, Schirle, Markus, Bueno-Lozano, Manuel, Ramos Fuentes, Feliciano J., Itin, Peter H., Boudin, Eveline, de Freitas, Fenna, Jennes, Karen, Brannetti, Barbara, Charara, Nadine, Ebersbach, Hilmar, Geisse, Sabine, Lu, Chris X., Bauer, Andreas, Van Hul, Wim, Kneissel, Michaela

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Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space von Cadena, Samuel M., Zhang, Yunyu, Fang, Jian, Brachat, Sophie, Kuss, Pia, Giorgetti, Elisa, Stodieck, Louis S., Kneissel, Michaela, Glass, David J.

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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally von Zhang, Yu, Kwon, SoHee, Yamaguchi, Teppei, Cubizolles, Fabien, Rousseaux, Sophie, Kneissel, Michaela, Cao, Chun, Li, Na, Cheng, Hwei-Ling, Chua, Katrin, Lombard, David, Mizeracki, Adam, Matthias, Gabriele, Alt, Frederick W., Khochbin, Saadi, Matthias, Patrick

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Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23‐mediated hypophosphatemic rickets von Wöhrle, Simon, Henninger, Christine, Bonny, Olivier, Thuery, Anne, Beluch, Noemie, Hynes, Nancy E, Guagnano, Vito, Sellers, William R, Hofmann, Francesco, Kneissel, Michaela, Graus Porta, Diana

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Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice von Albiol, Laia, Büttner, Alexander, Pflanz, David, Mikolajewicz, Nicholas, Birkhold, Annette I., Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Checa, Sara, Willie, Bettina M.

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Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors von Leupin, Olivier, Kramer, Ina, Collette, Nicole M, Loots, Gabriela G, Natt, François, Kneissel, Michaela, Keller, Hansjoerg

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Mef2c deletion in osteocytes results in increased bone mass von Kramer, Ina, Baertschi, Stefan, Halleux, Christine, Keller, Hansjoerg, Kneissel, Michaela

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Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease von Loots, Gabriela G, Kneissel, Michaela, Keller, Hansjoerg, Baptist, Myma, Chang, Jessie, Collette, Nicole M, Ovcharenko, Dmitriy, Plajzer-Frick, Ingrid, Rubin, Edward M

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Reversing LRP5‐Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity von Chang, Ming‐Kang, Kramer, Ina, Keller, Hansjoerg, Gooi, Jonathan H, Collett, Corinne, Jenkins, David, Ettenberg, Seth A, Cong, Feng, Halleux, Christine, Kneissel, Michaela

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Sclerostin Deficiency Is Linked to Altered Bone Composition von Hassler, Norbert, Roschger, Andreas, Gamsjaeger, Sonja, Kramer, Ina, Lueger, Sonja, van Lierop, Antoon, Roschger, Paul, Klaushofer, Klaus, Paschalis, Eleftherios P, Kneissel, Michaela, Papapoulos, Socrates

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Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH von Bedi, Brahmchetna, Li, Jau-Yi, Tawfeek, Hesham, Baek, Ki-Hyun, Adams, Jonathan, Vangara, Sameera S, Chang, Ming-Kang, Kneissel, Michaela, Weitzmann, M. Neale, Pacifici, Roberto

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Isolation of Mouse Osteocytes Using Cell Fractionation for Gene Expression Analysis von Halleux, Christine, Kramer, Ina, Allard, Cyril, Kneissel, Michaela

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