Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies von WONG, P. C., CRAIN, E. J., XIN, B., WEXLER, R. R., LAM, P. Y. S., PINTO, D. J., LUETTGEN, J. M., KNABB, R. M.

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Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 2 von Quan, Mimi L, Ellis, Christopher D, Liauw, Ann Y, Alexander, Richard S, Knabb, Robert M, Lam, Gilbert, Wright, Matthew R, Wong, Pancras C, Wexler, Ruth R

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Isoxazolines and isoxazoles as Factor Xa inhibitors von PRUITT, J. R, PINTO, D. J, ESTRELLA, M. J, BOSTROM, L. L, KNABB, R. M, WONG, P. C, WRIGHT, M. R, WEXLER, R. R

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Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1 von Quan, Mimi L, Liauw, Ann Y, Ellis, Christopher D, Pruitt, James R, Carini, David J, Bostrom, Lori L, Huang, Peggy P, Harrison, Kimberly, Knabb, Robert M, Thoolen, Martin J, Wong, Pancras C, Wexler, Ruth R

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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, an... von Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S

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Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonist von MOUSA, S. A, BOZARTH, J. M, DE GRADO, W. F, THOOLEN, M. J, REILLY, T. M, FORSYTHE, M. S, JACKSON, S. M, LEAMY, A, DIEMER, M. M, KAPIL, R. P, KNABB, R. M, MAYO, M. C, PIERCE, S. K

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Design, Synthesis, and Biological Evaluation of Potent and Selective Amidino Bicyclic Factor Xa Inhibitors von Han, Qi, Dominguez, Celia, Stouten, Pieter F. W, Park, Jeongsook M, Duffy, Daniel E, Galemmo, Robert A, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Wong, Pancras C, Wright, Matthew M, Luettgen, Joseph M, Knabb, Robert M, Wexler, Ruth R

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Rational Design and Synthesis of Novel, Potent Bis-phenylamidine Carboxylate Factor Xa Inhibitors von Maduskuie, Thomas P, McNamara, Kevin J, Ru, Yu, Knabb, Robert M, Stouten, Pieter F. W

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Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation von Wachtfogel, Y. T, Hack, C. E, Nuijens, J. H, Kettner, C, Reilly, T. M, Knabb, R. M, Bischoff, R, Tschesche, H, Wenzel, H, Kucich, U

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Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors von Duncia, John V., Santella, Joseph B., Anne Higley, C., VanAtten, Mary K., Weber, Patricia C., Alexander, Richard S., Kettner, Charles A., Pruitt, James R., Liauw, Anne Y., Quan, Mimi L., Knabb, Robert M., Wexler, Ruth R.

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Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors von CACCIOLA, J, FEVIG, J. M, STOUTEN, P. F. W, ALEXANDER, R. S, KNABB, R. M, WEXLER, R. R

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Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors von Quan, M.L., Pruitt, J.R., Ellis, C.D., Liauw, A.Y., Galemmo, R.A., Stouten, P.F.W., Wityak, J., Knabb, R.M., Thoolen, M.J., Wong, P.C., Wexler, R.R.

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The de novo design and synthesis of cyclic urea inhibitors of factor Xa : Optimization of the S4 ligand von GALEMMO, R. A, WELLS, B. L, KNABB, R. M, WEXLER, R. R, ROSSI, K. A, ALEXANDER, R. S, DOMINGUEZ, C, MADUSKUIE, T. P, STOUTEN, P. F. W, WRIGHT, M. R, AUNGST, B. J, WONG, P. C

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Preparation of meta-amidino- N, N-disubstituted anilines as potent inhibitors of coagulation factor Xa von Fevig, John M., Cacciola, Joseph, Alexander, Richard S., Knabb, Robert M., Lam, Gilbert N., Wong, Pancras C., Wexler, Ruth R.

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Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa von Fevig, John M., Buriak, Joseph, Stouten, Pieter F.W., Knabb, Robert M., Lam, Gilbert N., Wong, Pancras C., Wexler, Ruth R.

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BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies von Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Kettner, Charles A., Xin, Baomin, Knabb, Robert M., Wexler, Ruth R., Priestley, E. Scott

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Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors von Dominguez, Celia, Duffy, Daniel E., Han, Qi, Alexander, Richard S., Galemmo, Robert A., Park, Jeongsook M., Wong, Pancras C., Amparo, Eugene C., Knabb, Robert M., Luettgen, Joseph, Wexler, Ruth R.

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Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator von FOX, K. A. A, ROBISON, A. K, KNABB, R. M, ROSAMOND, T. L, SOBEL, B. E, BERGMANN, S. R

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Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats von XINKANG WANG, LIN XU, BERNARD, Roberta, VARGAS, Hugo, CHOPP, Michael, FRIEDMAN, Steven M, FEUERSTEIN, Giora Z, WANG, Hugh, GRZANNA, Reinhard, YUTIAN ZHAN, KNABB, Robert M, LUETTGEN, Joseph M, BOZARTH, Tracy A, GALEMMO, Robert A, WONG, Pancras C

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Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety prof... von Fevig, John M, Buriak, Joseph, Cacciola, Joseph, Alexander, Richard S, Kettner, Charles A, Knabb, Robert M, Pruitt, James R, Weber, Patricia C, Wexler, Ruth R

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