The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability von Hintzen, Dorine C, Soto, Mar, Schubert, Michael, Bakker, Bjorn, Spierings, Diana C. J, Szuhai, Karoly, Lansdorp, Peter M, Kluin, Roel J. C, Foijer, Floris, Medema, René H, Raaijmakers, Jonne A

Volltext

BRAFV600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts von Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, van der Velden, Daphne L., Bleijerveld, Onno B., Kuilman, Thomas, Kluin, Roel J.C., Sun, Chong, Voest, Emile E., Ju, Young Seok, Schumacher, Ton N.M., Altelaar, A.F. Maarten, McDermott, Ultan, Adams, David J., Blank, Christian U., Haanen, John B., Peeper, Daniel S.

Volltext

Effect of HIPEC according to HRD/BRCAwt genomic profile in stage III ovarian cancer: Results from the phase III OVHIPEC trial von Koole, Simone N., Schouten, Philip C., Hauke, Jan, Kluin, Roel J. C., Nederlof, Petra, Richters, Lisa K., Krebsbach, Gabriele, Sikorska, Karolina, Alkemade, Maartje, Opdam, Mark, Schagen van Leeuwen, Jules H., Schreuder, Henk W. R., Hermans, Ralph H. M., Hingh, Ignace H. J. T., Mom, Constantijne H., Arts, Henriette J. G., Ham, Maaike, Dam, Peter, Vuylsteke, Peter, Sanders, Joyce, Horlings, Hugo M., Vijver, Koen K., Hahnen, Eric, Driel, Willemien J., Schmutzler, Rita, Sonke, Gabe S., Linn, Sabine C.

Volltext

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts von Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, van der Velden, Daphne L, Bleijerveld, Onno B, Kuilman, Thomas, Kluin, Roel J C, Sun, Chong, Voest, Emile E, Ju, Young Seok, Schumacher, Ton N M, Altelaar, A F Maarten, McDermott, Ultan, Adams, David J, Blank, Christian U, Haanen, John B, Peeper, Daniel S

Volltext

Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamo... von Verhagen, Caroline V M, Vossen, David M, Borgmann, Kerstin, Hageman, Floor, Grénman, Reidar, Verwijs-Janssen, Manon, Mout, Lisanne, Kluin, Roel J C, Nieuwland, Marja, Severson, Tesa M, Velds, Arno, Kerkhoven, Ron, O'Connor, Mark J, van der Heijden, Martijn, van Velthuysen, Marie-Louise, Verheij, Marcel, Wreesmann, Volkert B, Wessels, Lodewyk F A, van den Brekel, Michiel W M, Vens, Conchita

Volltext

Abstract 5335: Discovery and validation of new kinase targets for therapy in ovarian clear cell cancer von Caumanns, Joseph J., de Jong, Steven, Wisman, G. Bea A., Van der Vlies, Pieter, Kluin, Roel J.C., Mittempergher, Lorenza, Berns, Katrien, Bernards, René, Zee, Ate G.J. Van der

Volltext

Effect of HIPEC according to HRD / BRCA wt genomic profile in stage III ovarian cancer: Results from the phase III OVHIPEC trial von Koole, Simone N., Schouten, Philip C., Hauke, Jan, Kluin, Roel J. C., Nederlof, Petra, Richters, Lisa K., Krebsbach, Gabriele, Sikorska, Karolina, Alkemade, Maartje, Opdam, Mark, Schagen van Leeuwen, Jules H., Schreuder, Henk W. R., Hermans, Ralph H. M., de Hingh, Ignace H. J. T., Mom, Constantijne H., Arts, Henriette J. G., van Ham, Maaike, van Dam, Peter, Vuylsteke, Peter, Sanders, Joyce, Horlings, Hugo M., van de Vijver, Koen K., Hahnen, Eric, van Driel, Willemien J., Schmutzler, Rita, Sonke, Gabe S., Linn, Sabine C.

Volltext

BRCA -like classification in ovarian cancer: Results from the AGO-TR1-trial von Richters, Lisa Katharina, Schouten, Philip C., Kommoss, Stefan, Hauke, Jan, Burges, Alexander, Dietrich, Dimo, El-Balat, Ahmed, Hilpert, Felix, Kluin, Roel, Heubner, Martin Leonhard, Kast, Karin, Heimbach, André, Braicu, Elena Ioana, Schmidt, Sandra, Baumann, Klaus H., Jackisch, Christian, Linn, Sabine C., Schmutzler, Rita K., Harter, Philipp, Hahnen, Eric

Volltext

BRAF super(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts von Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, Velden, Daphne Lvan der, Bleijerveld, Onno B, Kuilman, Thomas, Kluin, Roel JC, Sun, Chong, Voest, Emile E, Ju, Young Seok, Schumacher, Ton NM, Altelaar, AFMaarten, McDermott, Ultan, Adams, David J, Blank, Christian U, Haanen, John B, Peeper, Daniel S

Volltext

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts von Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, van der Velden, Daphne L, Bleijerveld, Onno B, Kuilman, Thomas, Kluin, Roel J C, Sun, Chong, Voest, Emile E, Ju, Young Seok, Schumacher, Ton N M, Altelaar, A F Maarten, McDermott, Ultan, Adams, David J, Blank, Christian U, Haanen, John B, Peeper, Daniel S

Volltext

BRAF V600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts von Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, van der Velden, Daphne L., Bleijerveld, Onno B., Kuilman, Thomas, Kluin, Roel J.C., Sun, Chong, Voest, Emile E., Ju, Young Seok, Schumacher, Ton N.M., Altelaar, A.F. Maarten, McDermott, Ultan, Adams, David J., Blank, Christian U., Haanen, John B., Peeper, Daniel S.

Volltext

The Early Phase of Engraftment after Murine Blood Cell Transplantation is Mediated by Hematopoietic Stem Cells von J. Mark J. M. Zijlmans, Jan W. M. Visser, Laterveer, Laurens, Kleiverda, Karin, Diana P. M. Heemskerk, Kluin, Philip M., Willemze, Roel, Fibbe, Willem E.

Volltext

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers von Scheper, Wouter, Kelderman, Sander, Fanchi, Lorenzo F., Linnemann, Carsten, Bendle, Gavin, de Rooij, Marije A. J., Hirt, Christian, Mezzadra, Riccardo, Slagter, Maarten, Dijkstra, Krijn, Kluin, Roelof J. C., Snaebjornsson, Petur, Milne, Katy, Nelson, Brad H., Zijlmans, Henry, Kenter, Gemma, Voest, Emile E., Haanen, John B. A. G., Schumacher, Ton N.

Volltext

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial von Voorwerk, Leonie, Slagter, Maarten, Horlings, Hugo M., Sikorska, Karolina, van de Vijver, Koen K., de Maaker, Michiel, Nederlof, Iris, Kluin, Roelof J. C., Warren, Sarah, Ong, SuFey, Wiersma, Terry G., Russell, Nicola S., Lalezari, Ferry, Schouten, Philip C., Bakker, Noor A. M., Ketelaars, Steven L. C., Peters, Dennis, Lange, Charlotte A. H., van Werkhoven, Erik, van Tinteren, Harm, Mandjes, Ingrid A. M., Kemper, Inge, Onderwater, Suzanne, Chalabi, Myriam, Wilgenhof, Sofie, Haanen, John B. A. G., Salgado, Roberto, de Visser, Karin E., Sonke, Gabe S., Wessels, Lodewyk F. A., Linn, Sabine C., Schumacher, Ton N., Blank, Christian U., Kok, Marleen

Volltext

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data von Kluin, Roelof J C, Kemper, Kristel, Kuilman, Thomas, de Ruiter, Julian R, Iyer, Vivek, Forment, Josep V, Cornelissen-Steijger, Paulien, de Rink, Iris, Ter Brugge, Petra, Song, Ji-Ying, Klarenbeek, Sjoerd, McDermott, Ultan, Jonkers, Jos, Velds, Arno, Adams, David J, Peeper, Daniel S, Krijgsman, Oscar

Volltext

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma von Ramirez, Christel F. A., Taranto, Daniel, Ando-Kuri, Masami, de Groot, Marnix H. P., Tsouri, Efi, Huang, Zhijie, de Groot, Daniel, Kluin, Roelof J. C., Kloosterman, Daan J., Verheij, Joanne, Xu, Jing, Vegna, Serena, Akkari, Leila

Volltext

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer von Majewski, Ian J, Kluijt, Irma, Cats, Annemieke, Scerri, Thomas S, de Jong, Daphne, Kluin, Roelof JC, Hansford, Samantha, Hogervorst, Frans BL, Bosma, Astrid J, Hofland, Ingrid, Winter, Marcel, Huntsman, David, Jonkers, Jos, Bahlo, Melanie, Bernards, René

Volltext

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer von Michaut, Magali, Chin, Suet-Feung, Majewski, Ian, Severson, Tesa M., Bismeijer, Tycho, de Koning, Leanne, Peeters, Justine K., Schouten, Philip C., Rueda, Oscar M., Bosma, Astrid J., Tarrant, Finbarr, Fan, Yue, He, Beilei, Xue, Zheng, Mittempergher, Lorenza, Kluin, Roelof J.C., Heijmans, Jeroen, Snel, Mireille, Pereira, Bernard, Schlicker, Andreas, Provenzano, Elena, Ali, Hamid Raza, Gaber, Alexander, O’Hurley, Gillian, Lehn, Sophie, Muris, Jettie J.F., Wesseling, Jelle, Kay, Elaine, Sammut, Stephen John, Bardwell, Helen A., Barbet, Aurélie S., Bard, Floriane, Lecerf, Caroline, O’Connor, Darran P., Vis, Daniël J., Benes, Cyril H., McDermott, Ultan, Garnett, Mathew J., Simon, Iris M., Jirström, Karin, Dubois, Thierry, Linn, Sabine C., Gallagher, William M., Wessels, Lodewyk F.A., Caldas, Carlos, Bernards, Rene

Volltext

Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients von de Boo, Leonora W., Jóźwiak, Katarzyna, Joensuu, Heikki, Lindman, Henrik, Lauttia, Susanna, Opdam, Mark, van Steenis, Charlaine, Brugman, Wim, Kluin, Roelof J. C., Schouten, Philip C., Kok, Marleen, Nederlof, Petra M., Hauptmann, Michael, Linn, Sabine C.

Volltext

Distinct spatiotemporal dynamics of CD8+ T cell-derived cytokines in the tumor microenvironment von Hoekstra, Mirjam E., Slagter, Maarten, Urbanus, Jos, Toebes, Mireille, Slingerland, Nadine, de Rink, Iris, Kluin, Roelof J.C., Nieuwland, Marja, Kerkhoven, Ron, Wessels, Lodewyk F.A., Schumacher, Ton N.

Volltext