Role of Dopamine Receptors in the Anticancer Activity of ONC201 von Kline, Christina Leah B., Ralff, Marie D., Lulla, Amriti R., Wagner, Jessica M., Abbosh, Phillip H., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.

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Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53 von Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A Pieter J, Prabhu, Varun V, Warfel, Noel A, Kline, Christina Leah B, Dicker, David T, Kopelovich, Levy, El-Deiry, Wafik S

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Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors von Prabhu, Varun V, Lulla, Amriti R, Madhukar, Neel S, Ralff, Marie D, Zhao, Dan, Kline, Christina Leah B, Van den Heuvel, A Pieter J, Lev, Avital, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Batchelor, Tracy T, Chi, Andrew S, Elemento, Olivier, Allen, Joshua E, El-Deiry, Wafik S

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The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU von Kline, Christina Leah B., Irby, Rosalyn B.

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Personalizing colon cancer therapeutics: targeting old and new mechanisms of action von Kline, Christina Leah B, El-Deiry, Wafik S

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Abstract 2497: ONC201 targets cancer stem cells in colorectal, prostate and glioblastoma multiforme tumors via modulation of stem cell-related gene expression von Prabhu, Varun Vijay, Allen, Joshua E., Zhao, Dan, Lulla, Amriti R., Kline, Christina Leah B., van den Heuvel, A. Pieter J., Lev, Avital, Batchelor, Tracy T., Dicker, David T., Chi, Andrew S., El-Deiry, Wafik S.

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Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network von Wang, Bi-Dar, Kline, Christina Leah B., Pastor, Danielle M., Olson, Thomas L., Frank, Bryan, Luu, Truong, Sharma, Arun K., Robertson, Gavin, Weirauch, Matthew T., Patierno, Steven R., Stuart, Joshua M., Irby, Rosalyn B., Lee, Norman H.

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Personalized Dosing via Pharmacokinetic Monitoring of 5-Fluorouracil Might Reduce Toxicity in Early- or Late-Stage Colorectal Cancer Patients Treated With Infusional 5–Fluorouracil... von Kline, Christina Leah B, Schiccitano, Angelique, Zhu, Junjia, Beachler, Cheryl, Sheikh, Hassan, Harvey, Harold A, Mackley, Heath B, McKenna, Kevin, Staveley-O'Carroll, Kevin, Poritz, Lisa, Messaris, Evangelos, Stewart, David, Sivik, Jeffrey, El-Deiry, Wafik S

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Src kinase induces tumor formation in the c‐SRC C57BL/6 mouse von Kline, Christina Leah B., Jackson, Rosalind, Engelman, Robert, Pledger, Warren Jack, Yeatman, Timothy J., Irby, Rosalyn B.

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Src activity alters α3 integrin expression in colon tumor cells von Kline, Christina Leah B, Olson, Thomas L, Irby, Rosalyn B

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Glucosamine-induced phosphorylation of the α-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase von Kline, Christina Leah B., Schrufer, Tabitha L., Jefferson, Leonard S., Kimball, Scot R.

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Abstract 3014: ONC201 anti-cancer effects against solid tumors are mediated through eIF2α kinases HRI and PKR but are PERK-independent von Kline, Christina Leah B., El-Deiry, Wafik S.

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Dose-intensified ONC201 to exert anti-metastatic efficacy and to promote intra-tumoral recruitment of NK-cells in mice von Wagner, Jessica, Kline, Christina Leah B., El-Deiry, Wafik S.

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Abstract 3213: Antagonism of D2-like dopamine receptors plays a role in Onc201’s anticancer effects von Kline, Christina Leah B., Lulla, Amriti, Wagner, Jessica, Dicker, David, Baumeister, Marie, Oster, Sophie, El-Deiry, Wafik

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Role of Dopamine Receptors in the Anticancer Activity of ONC20112 von Kline, Christina Leah B., Ralff, Marie D., Lulla, Amriti R., Wagner, Jessica M., Abbosh, Phillip H., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.

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Abstract 1802: Small molecule compound NCI-8 induces mutant p53 degradation via inhibition of the MDM2-Hsp90 axis von Zhang, Shengliang, Zhou, Lanlan, Kline, Christina Leah B., Dicker, David T., El-Deiry, Wafik S.

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Preclinical activity of new investigational drug ONC201 in triple-negative and non-triple negative and BRCA1-deficient breast cancer cells von Baumeister, Marie D, Wagner, Jessica, Prabhu, Varun V., Kline, Christina Leah B., Allen, Joshua E., Dicker, David T., El-Deiry, Wafik S.

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Small molecule NSC59984 restores p53 pathway signaling and anti-tumor effects against colorectal cancer via p73 activation and degradation of mutant p53 von Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A. Pieter J., Prabhu, Varun V., Warfel, Noel A., Kline, Christina Leah B., Dicker, David T., Kopelovich, Levy, El-Deiry, Wafik S.

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Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM) von Lulla, Amriti R., Kline, Christina Leah B, Hernandez-Borrero, Liz J., Prabhu, Varun Vijay, Wagner, Jessica M, Dicker, David T., Dolloff, Nathan G., Barth, Brian M, Pu, Jeffrey J, Claxton, David F., Allen, Joshua E., El-Deiry, Wafik S.

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Abstract 1176: Pharmacokinetic monitoring of 5-FU appears beneficial in stage II-IV colorectal cancer patients treated with different 5-FU-based chemotherapeutic regimens von Kline, Christina Leah B., Schiccitano, Angelique, Zhu, Jay, Beachler, Cheryl, Sheikh, Hassan, Harvey, Harold, Mackley, Heath, Koltun, Walter, McKenna, Kevin, Poritz, Lisa, Messaris, Evangelos, Stewart, David, Sivik, Jeffrey, El-Deiry, Wafik

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