Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism von Prabhu, Varun V, Madhukar, Neel S, Gilvary, Coryandar, Kline, C Leah B, Oster, Sophie, El-Deiry, Wafik S, Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S, Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M, Gilbert, Mark R, Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Wen, Patrick Y, Oster, Wolfgang, Allen, Joshua E

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases von Kline, C Leah B, Van den Heuvel, A Pieter J, Allen, Joshua E, Prabhu, Varun V, Dicker, David T, El-Deiry, Wafik S

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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies von Prabhu, Varun V, Talekar, Mala K, Lulla, Amriti R, Kline, C Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A Pieter J, Dicker, David T, Babar, Jawad, Grupp, Stephan A, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Khan, Nadia, Oster, Wolfgang, Allen, Joshua E, El-Deiry, Wafik S

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Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.

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Abstract A060: Targeting DRD2 dysregulation in recurrent glioblastoma with imipridone ONC201: predictive and pharmacodynamic clinical biomarker analyses von Prabhu, Varun Vijay, Madhukar, Neel, Kline, C. Leah B., Tarapore, Rohinton, El-Deiry, Wafik, Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Zloza, Andrew, Benes, Cyril, Arrillaga, Isabel, Oster, Wolfgang, Allen, Joshua E.

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DRES-10. DRD5 IS A MODULATOR OF GLIOMA SUSCEPTIBILITY TO DRD2 ANTAGONISM BY ONC201 von Vijay Prabhu, Varun, Madhukar, Neel, Gilvary, Coryandar, Kline, C Leah B, Tarapore, Rohinton, El-Deiry, Wafik, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Oster, Wolfgang, Elemento, Olivier, Allen, Joshua

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Abstract 3857: Selective targeting of dopamine receptor dysregulation in high grade gliomas with imipridone ONC201 von Prabhu, Varun Vijay, Madhukar, Neel, Kline, C. Leah B., Tarapore, Rohinton, El-Deiry, Wafik S., Rucker, Joseph, Doranz, Benjamin, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Deacon, Sean, Charter, Neil, Free, R. Benjamin, Oster, Wolfgang, Sibley, David, Arrillaga, Isabel, Elemento, Olivier, Allen, Joshua E.

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Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the... von Prabhu, Varun Vijay, Talekar, Mala Kiran, Lulla, Amriti R, Kline, C. Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A. Pieter J, Dicker, David T, Grupp, Stephan A, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.

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DDIS-08. THE SMALL MOLECULE IMIPRIDONE ONC201 IS ACTIVE IN GLIOBLASTOMA WITH DRD2 PATHWAY DYSREGULATION von Prabhu, Varun Vijay, Madhukar, Neel, Kline, C Leah B, Tarapore, Rohinton S, El-Deiry, Wafik, Elemento, Olivier, Rucker, Joseph, Doranz, Benjamin, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Arrillaga-Romany, Isabel, Oster, Wolfgang, Allen, Joshua E

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C. Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B. Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies von Varun V. Prabhu, Talekar, Mala K., Amriti R. Lulla, C. Leah B. Kline, Lanlan Zhou, Junior Hall, A. Pieter J. Van Den Heuvel, Dicker, David T., Babar, Jawad, Grupp, Stephan A., Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Pu, Jeffrey J., Claxton, David F., Khan, Nadia, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.

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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies von Prabhu, Varun V., Talekar, Mala K., Lulla, Amriti R., Kline, C. Leah B., Zhou, Lanlan, Hall, Junior, Van den Heuvel, A. Pieter J., Dicker, David T., Babar, Jawad, Grupp, Stephan A., Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Pu, Jeffrey J., Claxton, David F., Khan, Nadia, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.

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Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment von Wagner, Jessica, Kline, C Leah, Zhou, Lanlan, Campbell, Kerry S, MacFarlane, Alexander W, Olszanski, Anthony J, Cai, Kathy Q, Hensley, Harvey H, Ross, Eric A, Ralff, Marie D, Zloza, Andrew, Chesson, Charles B, Newman, Jenna H, Kaufman, Howard, Bertino, Joseph, Stein, Mark, El-Deiry, Wafik S

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