Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells von Dimozi, A, Mavrogonatou, E, Sklirou, A, Kletsas, D

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Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues von Georgakopoulou, E A, Tsimaratou, K, Evangelou, K, Fernandez Marcos, P J, Zoumpourlis, V, Trougakos, I P, Kletsas, D, Bartek, J, Serrano, M, Gorgoulis, V G

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Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid von Dedes, P.G., Gialeli, Ch, Tsonis, A.I., Kanakis, I., Theocharis, A.D., Kletsas, D., Tzanakakis, G.N., Karamanos, N.K.

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Senescence in human intervertebral discs von Roberts, S, Evans, E H, Kletsas, D, Jaffray, D C, Eisenstein, S M

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Cyclic tensile stress of human annulus fibrosus cells induces MAPK activation: involvement in proinflammatory gene expression von Pratsinis, H, Papadopoulou, A, Neidlinger-Wilke, C, Brayda-Bruno, M, Wilke, H.-J, Kletsas, D

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Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab von Gialeli, Ch, Theocharis, A. D., Kletsas, D., Tzanakakis, G. N., Karamanos, N. K.

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In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes von Israilides, C., Kletsas, D., Arapoglou, D., Philippoussis, A., Pratsinis, H., Ebringerová, A., Hříbalová, V., Harding, S.E.

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Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial... von Gialeli, Ch, Viola, M., Barbouri, D., Kletsas, D., Passi, A., Karamanos, N.K.

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Are umbilical cord mesenchymal stem cells advantageous over bone marrow mesenchymal stem cells for cell therapy in orthopaedics? von Mennan, C, Owen, S, Mayrogonatou, E, Kletsas, D, Oldershaw, R, Richardson, J, Roberts, S

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Robust, universal biomarker assay to detect senescent cells in biological specimens von Evangelou, Konstantinos, Lougiakis, Nikolaos, Rizou, Sophia V., Kotsinas, Athanassios, Kletsas, Dimitris, Muñoz‐Espín, Daniel, Kastrinakis, Nikolaos G, Pouli, Nicole, Marakos, Panagiotis, Townsend, Paul, Serrano, Manuel, Bartek, Jiri, Gorgoulis, Vassilis G.

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Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease von Dedes, P.G., Kanakis, I., Gialeli, Ch, Theocharis, A.D., Tsegenidis, T., Kletsas, D., Tzanakakis, G.N., Karamanos, N.K.

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Effect of blue light on the proliferation of human gingival fibroblasts von Taoufik, K, Mavrogonatou, E, Eliades, T, Papagiannoulis, L, Eliades, G, Kletsas, D

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Characterization and in vitro estrogenicity of orthodontic adhesive particulates produced by simulated debonding von Gioka, C, Eliades, T, Zinelis, S, Pratsinis, H, Athanasiou, A.E, Eliades, G, Kletsas, D

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1008 POSTER The Effects of Telomerase Inhibitor GRN163L(lmetelstat) on Cell Cytoskeleton, Cell Cycle and Matrix Metalloproteinases von Mender, I, Dikmen, Z, Gryaznov, S, Kletsas, D, Erbil, K

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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing von Galanos, Panagiotis, Vougas, Konstantinos, Walter, David, Polyzos, Alexander, Maya-Mendoza, Apolinar, Haagensen, Emma J., Kokkalis, Antonis, Roumelioti, Fani-Marlen, Gagos, Sarantis, Tzetis, Maria, Canovas, Begoña, Igea, Ana, Ahuja, Akshay K., Zellweger, Ralph, Havaki, Sofia, Kanavakis, Emanuel, Kletsas, Dimitris, Roninson, Igor B., Garbis, Spiros D., Lopes, Massimo, Nebreda, Angel, Thanos, Dimitris, Blow, J. Julian, Townsend, Paul, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G.

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Evaluation of claspin as a proliferation marker in human cancer and normal tissues von Tsimaratou, K, Kletsas, D, Kastrinakis, NG, Tsantoulis, PK, Evangelou, K, Sideridou, M, Liontos, M, Poulias, I, Venere, M, Salmas, M, Kittas, C, Halazonetis, TD, Gorgoulis, VG

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Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha von Kundakovic, T., Fokialakis, N., Dobric, S., Pratsinis, H., Kletsas, D., Kovacevic, N., Chinou, I.

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High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair respons... von Mavrogonatou, Eleni, Kletsas, Dimitris

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Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy von Angelopoulou, Andriani, Theocharous, Giorgos, Valakos, Dimitrios, Polyzou, Aikaterini, Magkouta, Sophia, Myrianthopoulos, Vassilios, Havaki, Sophia, Fiorillo, Marco, Tremi, Ioanna, Vachlas, Konstantinos, Nisotakis, Theodoros, Thanos, Dimitris-Foivos, Pantazaki, Anastasia, Kletsas, Dimitris, Bartek, Jiri, Petty, Russell, Thanos, Dimitris, McCrimmon, Rory J, Papaspyropoulos, Angelos, Gorgoulis, Vassilis G

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions von DiTullio, Richard A, Vassiliou, Leandros-Vassilios F, Karakaidos, Panagiotis, Kastrinakis, Nikolaos G, Halazonetis, Thanos D, Liloglou, Triantafillos, Yoneta, Akihiro, Kletsas, Dimitris, Kotsinas, Athanassios, Kittas, Christos, Zacharatos, Panayotis, Gorgoulis, Vassilis G, Herlyn, Meenhard, Venere, Monica, Levy, Brynn

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