Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms von Kleppe, Maria, Koche, Richard, Zou, Lihua, van Galen, Peter, Hill, Corinne E., Dong, Lauren, De Groote, Sofie, Papalexi, Efthymia, Hanasoge Somasundara, Amritha V., Cordner, Keith, Keller, Matthew, Farnoud, Noushin, Medina, Juan, McGovern, Erin, Reyes, Jaime, Roberts, Justin, Witkin, Matthew, Rapaport, Franck, Teruya-Feldstein, Julie, Qi, Jun, Rampal, Raajit, Bernstein, Bradley E., Bradner, James E., Levine, Ross L.

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JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response von Kleppe, Maria, Kwak, Minsuk, Koppikar, Priya, Riester, Markus, Keller, Matthew, Bastian, Lennart, Hricik, Todd, Bhagwat, Neha, McKenney, Anna Sophia, Papalexi, Efthymia, Abdel-Wahab, Omar, Rampal, Raajit, Marubayashi, Sachie, Chen, Jonathan J, Romanet, Vincent, Fridman, Jordan S, Bromberg, Jacqueline, Teruya-Feldstein, Julie, Murakami, Masato, Radimerski, Thomas, Michor, Franziska, Fan, Rong, Levine, Ross L

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Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms von Kleppe, Maria, Koche, Richard, Zou, Lihua, van Galen, Peter, Hill, Corinne E., Dong, Lauren, De Groote, Sofie, Papalexi, Efthymia, Hanasoge Somasundara, Amritha V., Cordner, Keith, Keller, Matthew, Farnoud, Noushin, Medina, Juan, McGovern, Erin, Reyes, Jaime, Roberts, Justin, Witkin, Matthew, Rapaport, Franck, Teruya-Feldstein, Julie, Qi, Jun, Rampal, Raajit, Bernstein, Bradley E., Bradner, James E., Levine, Ross L.

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Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms von Bhagwat, Neha, Koppikar, Priya, Keller, Matthew, Marubayashi, Sachie, Shank, Kaitlyn, Rampal, Raajit, Qi, Jun, Kleppe, Maria, Patel, Hardik J., Shah, Smit K., Taldone, Tony, Bradner, James E., Chiosis, Gabriela, Levine, Ross L.

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Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment von Comen, Elizabeth A, Bowman, Robert L, Kleppe, Maria

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TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis von Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.

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Tumor Heterogeneity Confounds and Illuminates: Assessing the implications von Kleppe, Maria, Levine, Ross L

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Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis von Poulos, Michael G., Ramalingam, Pradeep, Gutkin, Michael C., Kleppe, Maria, Ginsberg, Michael, Crowley, Michael J. P., Elemento, Olivier, Levine, Ross L., Rafii, Shahin, Kitajewski, Jan, Greenblatt, Matthew B., Shim, Jae-Hyuck, Butler, Jason M.

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LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone von Jutzi, Jonas S., Kleppe, Maria, Dias, Jennifer, Staehle, Hans Felix, Shank, Kaitlyn, Teruya‐Feldstein, Julie, Gambheer, Sudheer Madan Mohan, Dierks, Christine, Rienhoff, Hugh Y., Levine, Ross L., Pahl, Heike L.

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Tumor heterogeneity confounds and illuminates

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Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms von Hobbs, Gabriela S, Hanasoge Somasundara, Amritha Varshini, Kleppe, Maria, Litvin, Rivka, Arcila, Maria, Ahn, Jihae, McKenney, Anna Sophia, Knapp, Kristina, Ptashkin, Ryan, Weinstein, Howard, Heinemann, Murk-Hein, Francis, Jasmine, Chanel, Suzanne, Berman, Ellin, Mauro, Michael, Tallman, Martin S, Heaney, Mark L, Levine, Ross L, Rampal, Raajit K

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Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms von Shank, Kaitlyn, Dunbar, Andrew, Koppikar, Priya, Kleppe, Maria, Teruya-Feldstein, Julie, Csete, Isabelle, Bhagwat, Neha, Keller, Matthew, Kilpivaara, Outi, Michor, Franziska, Levine, Ross L, de Vargas Roditi, Laura

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Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin’s lymphoma and T-cell non-Hodgkin’s lymphoma von KLEPPE, Maria, TOUSSEYN, Thomas, GEISSINGER, Eva, ATAK, Zeynep Kalender, AERTS, Stein, ROSENWALD, Andreas, WLODARSKA, Iwona, COOLS, Jan

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Correction: Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group’s clinical trial E3999 von Rapaport, Franck, Seier, Kenneth, Neelamraju, Yaseswini, Hassane, Duane, Baslan, Timour, Gildea, Daniel T., Haddox, Samuel, Lee, Tak, Murdock, H. Moses, Sheridan, Caroline, Thurmond, Alexis, Wang, Ling, Carroll, Martin, Cripe, Larry D., Fernandez, Hugo, Mason, Christopher E., Paietta, Elisabeth, Roboz, Gail J., Sun, Zhuoxin, Tallman, Martin S., Zhang, Yanming, Gönen, Mithat, Levine, Ross, Melnick, Ari M., Kleppe, Maria, Garrett-Bakelman, Francine E.

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Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group’s clinical trial E3999 von Rapaport, Franck, Seier, Kenneth, Neelamraju, Yaseswini, Hassane, Duane, Baslan, Timour, Gildea, Daniel T., Haddox, Samuel, Lee, Tak, Murdock, H. Moses, Sheridan, Caroline, Thurmond, Alexis, Wang, Ling, Carroll, Martin, Cripe, Larry D., Fernandez, Hugo, Mason, Christopher E., Paietta, Elisabeth, Roboz, Gail J., Sun, Zhuoxin, Tallman, Martin S., Zhang, Yanming, Gönen, Mithat, Levine, Ross, Melnick, Ari M., Kleppe, Maria, Garrett-Bakelman, Francine E.

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MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context von KLEPPE, Maria, MENTENS, Nicole, TOUSSEYN, Thomas, WLODARSKA, Iwona, COOLS, Jan

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Somatic mutations in leukocytes infiltrating primary breast cancers von Kleppe, Maria, Comen, Elizabeth, Wen, Hannah Y, Bastian, Lennart, Blum, Brian, Rapaport, Franck T, Keller, Matthew, Granot, Zvika, Socci, Nicolas, Viale, Agnès, You, Daoqi, Benezra, Robert, Weigelt, Britta, Brogi, Edi, Berger, Michael F, Reis-Filho, Jorge S, Levine, Ross L, Norton, Larry

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MSC Reprogramming and Aberrant Inflammatory Signaling in Myelofibrosis: Insights from Single-Cell RNA-Sequencing of Trephine Bone Marrow Cells von Basma, Naseer J, Strickson, Alexia J, Gurashi, Kristian, Kleppe, Maria, Rienhoff Jr, Hugh Young, Somervaille, Tim CP

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Mutational Analysis of the Genome Stability Factor BOD1L1 in Myeloproliferative Neoplasm von Higgs, Martin R, Browne, Sofia, Collinson, Ryan, Fuller, Kathy, Erber, Wendy N., Kleppe, Maria, Sirnosian, Ben, Natsoulis, Georges, Guo, Belinda, Rienhoff Jr, Hugh Young

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Toll-like receptor alterations in myelodysplastic syndrome von Wei, Y, Dimicoli, S, Bueso-Ramos, C, Chen, R, Yang, H, Neuberg, D, Pierce, S, Jia, Y, Zheng, H, Wang, H, Wang, X, Nguyen, M, Wang, S A, Ebert, B, Bejar, R, Levine, R, Abdel-Wahab, O, Kleppe, M, Ganan-Gomez, I, Kantarjian, H, Garcia-Manero, G

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