Cost-effectiveness of a multidimensional post-discharge disease management program for heart failure patients—economic evaluation along a one-year observation period von Egelseer-Bruendl, T., Jahn, B., Arvandi, M., Puntscher, S., Santamaria, J., Brunelli, L., Weissenegger, K., Pfeifer, B., Neururer, S., Rissbacher, C., Huber, A., Fetz, B., Kleinheinz, C., Modre-Osprian, R., Kreiner, K., Siebert, U., Poelzl, G.

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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing von Hovestadt, Volker, Jones, David T. W., Picelli, Simone, Wang, Wei, Kool, Marcel, Northcott, Paul A., Sultan, Marc, Stachurski, Katharina, Ryzhova, Marina, Warnatz, Hans-Jörg, Ralser, Meryem, Brun, Sonja, Bunt, Jens, Jäger, Natalie, Kleinheinz, Kortine, Erkek, Serap, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Lawerenz, Chris, Eils, Jürgen, Koster, Jan, Versteeg, Rogier, Milde, Till, Witt, Olaf, Schmidt, Sabine, Wolf, Stephan, Pietsch, Torsten, Rutkowski, Stefan, Scheurlen, Wolfram, Taylor, Michael D., Brors, Benedikt, Felsberg, Jörg, Reifenberger, Guido, Borkhardt, Arndt, Lehrach, Hans, Wechsler-Reya, Robert J., Eils, Roland, Yaspo, Marie-Laure, Landgraf, Pablo, Korshunov, Andrey, Zapatka, Marc, Radlwimmer, Bernhard, Pfister, Stefan M., Lichter, Peter

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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes von Dentro, Stefan C., Leshchiner, Ignaty, Haase, Kerstin, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Vázquez-García, Ignacio, Kleinheinz, Kortine, Livitz, Dimitri G., Malikic, Salem, Donmez, Nilgun, Sengupta, Subhajit, Anur, Pavana, Jolly, Clemency, Rosebrock, Daniel, Schumacher, Steven E., Fittall, Matthew, Drews, Ruben M., Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Zhu, Hongtu, Adams, David J., McGranahan, Nicholas, Swanton, Charles, Getz, Gad, Boutros, Paul C., Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Martincorena, Inigo, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Gerstung, Moritz, Spellman, Paul T., Wang, Wenyi, Wedge, David C., Dentro, Stefan C., Leshchiner, Ignaty, Gerstung, Moritz, Jolly, Clemency, Haase, Kerstin, Tarabichi, Maxime, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D., Cao, Shaolong, Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew, Getz, Gad, Ha, Gavin, Imielinski, Marcin, Ji, Yuan, Kleinheinz, Kortine, Lee, Juhee, Lee-Six, Henry, Livitz, Dimitri G., Malikic, Salem, Markowetz, Florian, Martincorena, Inigo, Mustonen, Ville, Oesper, Layla, Peifer, Martin, Peto, Myron, Raphael, Benjamin J., Rosebrock, Daniel, Salcedo, Adriana, Schumacher, Steven E., Sengupta, Subhajit, Shi, Ruian, Spiro, Oliver, Vázquez-García, Ignacio, Vembu, Shankar, Wheeler, David A., Yao, Xiaotong, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

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The whole-genome landscape of medulloblastoma subtypes von Northcott, Paul A., Buchhalter, Ivo, Morrissy, A. Sorana, Hovestadt, Volker, Weischenfeldt, Joachim, Ehrenberger, Tobias, Gröbner, Susanne, Segura-Wang, Maia, Zichner, Thomas, Rudneva, Vasilisa A., Warnatz, Hans-Jörg, Sidiropoulos, Nikos, Phillips, Aaron H., Schumacher, Steven, Kleinheinz, Kortine, Waszak, Sebastian M., Erkek, Serap, Jones, David T. W., Worst, Barbara C., Kool, Marcel, Zapatka, Marc, Jäger, Natalie, Chavez, Lukas, Hutter, Barbara, Bieg, Matthias, Paramasivam, Nagarajan, Heinold, Michael, Gu, Zuguang, Ishaque, Naveed, Jäger-Schmidt, Christina, Imbusch, Charles D., Jugold, Alke, Hübschmann, Daniel, Risch, Thomas, Amstislavskiy, Vyacheslav, Gonzalez, Francisco German Rodriguez, Weber, Ursula D., Wolf, Stephan, Robinson, Giles W., Zhou, Xin, Wu, Gang, Finkelstein, David, Liu, Yanling, Cavalli, Florence M. G., Luu, Betty, Ramaswamy, Vijay, Wu, Xiaochong, Koster, Jan, Ryzhova, Marina, Cho, Yoon-Jae, Pomeroy, Scott L., Herold-Mende, Christel, Schuhmann, Martin, Ebinger, Martin, Liau, Linda M., Mora, Jaume, McLendon, Roger E., Jabado, Nada, Kumabe, Toshihiro, Chuah, Eric, Ma, Yussanne, Moore, Richard A., Mungall, Andrew J., Mungall, Karen L., Thiessen, Nina, Tse, Kane, Wong, Tina, Jones, Steven J. M., Witt, Olaf, Milde, Till, Von Deimling, Andreas, Capper, David, Korshunov, Andrey, Yaspo, Marie-Laure, Kriwacki, Richard, Gajjar, Amar, Zhang, Jinghui, Beroukhim, Rameen, Fraenkel, Ernest, Korbel, Jan O., Brors, Benedikt, Schlesner, Matthias, Eils, Roland, Marra, Marco A., Pfister, Stefan M., Taylor, Michael D., Lichter, Peter

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Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility von Guan, Jane, Zhou, Wei, Hafner, Marc, Blake, Robert A., Chalouni, Cecile, Chen, Irene P., De Bruyn, Tom, Giltnane, Jennifer M., Hartman, Steven J., Heidersbach, Amy, Houtman, Rene, Ingalla, Ellen, Kategaya, Lorn, Kleinheinz, Tracy, Li, Jun, Martin, Scott E., Modrusan, Zora, Nannini, Michelle, Oeh, Jason, Ubhayakar, Savita, Wang, Xiaojing, Wertz, Ingrid E., Young, Amy, Yu, Mamie, Sampath, Deepak, Hager, Jeffrey H., Friedman, Lori S., Daemen, Anneleen, Metcalfe, Ciara

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Incidence of pemphigoid diseases in Northern Germany in 2016 – first data from the Schleswig‐Holstein Registry of Autoimmune Bullous Diseases von Beek, N., Weidinger, A., Schneider, S.W., Kleinheinz, A., Gläser, R., Holtsche, M.M., Georg, A., Hammers, C.M., Hübner, F., Lima, A.‐L., Gola, D., Sadik, C.D., Zillikens, D., Katalinic, A., Schmidt, E., König, I.R.

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The evolutionary history of 2,658 cancers von Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C., Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J., Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vázquez-García, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G., Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C., Bowtell, David D., Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

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The landscape of genomic alterations across childhood cancers von Gröbner, Susanne N., Worst, Barbara C., Weischenfeldt, Joachim, Buchhalter, Ivo, Kleinheinz, Kortine, Rudneva, Vasilisa A., Johann, Pascal D., Balasubramanian, Gnana Prakash, Segura-Wang, Maia, Brabetz, Sebastian, Bender, Sebastian, Hutter, Barbara, Sturm, Dominik, Pfaff, Elke, Hübschmann, Daniel, Zipprich, Gideon, Heinold, Michael, Eils, Jürgen, Lawerenz, Christian, Erkek, Serap, Lambo, Sander, Waszak, Sebastian, Blattmann, Claudia, Borkhardt, Arndt, Kuhlen, Michaela, Eggert, Angelika, Fulda, Simone, Gessler, Manfred, Wegert, Jenny, Kappler, Roland, Baumhoer, Daniel, Burdach, Stefan, Kirschner-Schwabe, Renate, Kontny, Udo, Kulozik, Andreas E., Lohmann, Dietmar, Hettmer, Simone, Eckert, Cornelia, Bielack, Stefan, Nathrath, Michaela, Niemeyer, Charlotte, Richter, Günther H., Schulte, Johannes, Siebert, Reiner, Westermann, Frank, Molenaar, Jan J., Vassal, Gilles, Witt, Hendrik, Burkhardt, Birgit, Kratz, Christian P., Witt, Olaf, van Tilburg, Cornelis M., Kramm, Christof M., Fleischhack, Gudrun, Dirksen, Uta, Rutkowski, Stefan, Frühwald, Michael, von Hoff, Katja, Wolf, Stephan, Klingebiel, Thomas, Koscielniak, Ewa, Landgraf, Pablo, Koster, Jan, Resnick, Adam C., Zhang, Jinghui, Liu, Yanling, Zhou, Xin, Waanders, Angela J., Zwijnenburg, Danny A., Raman, Pichai, Brors, Benedikt, Weber, Ursula D., Northcott, Paul A., Pajtler, Kristian W., Kool, Marcel, Piro, Rosario M., Korbel, Jan O., Schlesner, Matthias, Eils, Roland, Jones, David T. W., Lichter, Peter, Chavez, Lukas, Zapatka, Marc, Pfister, Stefan M.

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Implementation of dupilumab in routine care of atopic eczema: results from the German national registry TREATgermany von Abraham, S., Haufe, E., Harder, I., Heratizadeh, A., Kleinheinz, A., Wollenberg, A., Weisshaar, E., Augustin, M., Wiemers, F., Zink, A., Biedermann, T., Kiedrowski, R., Hilgers, M., Worm, M., Pawlak, M., Sticherling, M., Fell, I., Handrick, C., Schäkel, K., Staubach, P., Asmussen, A., Schwarz, B., Bell, M., Neubert, K., Effendy, I., Bieber, T., Homey, B., Gerlach, B., Tchitcherina, E., Stahl, M., Schwichtenberg, U., Rossbacher, J., Buck, P., Mempel, M., Beissert, S., Werfel, T., Weidinger, S., Schmitt, J.

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Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany von Heratizadeh, A., Haufe, E., Stölzl, D., Abraham, S., Heinrich, L., Kleinheinz, A., Wollenberg, A., Weisshaar, E., Augustin, M., Wiemers, F., Zink, A., Kiedrowski, R., Hilgers, M., Worm, M., Pawlak, M., Sticherling, M., Fell, I., Handrick, C., Schäkel, K., Staubach‐Renz, P., Asmussen, A., Schwarz, B., Bell, M., Effendy, I., Bieber, T., Homey, B., Gerlach, B., Tchitcherina, E., Stahl, M., Schwichtenberg, U., Rossbacher, J., Buck, P., Mempel, M., Beissert, S., Biedermann, T., Weidinger, S., Schmitt, J., Werfel, T.

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The landscape of viral associations in human cancers von Zapatka, Marc, Borozan, Ivan, Brewer, Daniel S., Iskar, Murat, Grundhoff, Adam, Alawi, Malik, Desai, Nikita, Sültmann, Holger, Moch, Holger, Cooper, Colin S., Eils, Roland, Ferretti, Vincent, Lichter, Peter

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Distribution of bone thickness in the human mandibular ramus – a CBCT-based study von Kronseder, K, Runte, C, Kleinheinz, J, Jung, S, Dirksen, D

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USP7 small-molecule inhibitors interfere with ubiquitin binding von Kategaya, Lorna, Di Lello, Paola, Rougé, Lionel, Pastor, Richard, Clark, Kevin R., Drummond, Jason, Kleinheinz, Tracy, Lin, Eva, Upton, John-Paul, Prakash, Sumit, Heideker, Johanna, McCleland, Mark, Ritorto, Maria Stella, Alessi, Dario R., Trost, Matthias, Bainbridge, Travis W., Kwok, Michael C. M., Ma, Taylur P., Stiffler, Zachary, Brasher, Bradley, Tang, Yinyan, Jaishankar, Priyadarshini, Hearn, Brian R., Renslo, Adam R., Arkin, Michelle R., Cohen, Frederick, Yu, Kebing, Peale, Frank, Gnad, Florian, Chang, Matthew T., Klijn, Christiaan, Blackwood, Elizabeth, Martin, Scott E., Forrest, William F., Ernst, James A., Ndubaku, Chudi, Wang, Xiaojing, Beresini, Maureen H., Tsui, Vickie, Schwerdtfeger, Carsten, Blake, Robert A., Murray, Jeremy, Maurer, Till, Wertz, Ingrid E.

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Omalizumab is effective and safe in chronic inducible urticaria (CIndU): Real-world data from a large multi-national UCARE study von Soegiharto, R, Alizadeh Aghdam, M, Sørensen, J A, van Lindonk, E, Bulut Demir, F, Mohammad Porras, N, Matsuo, Y, Kiefer, L, Knulst, A C, Maurer, M, Ritchie, C, Rudenko, M, Kocatürk, E, Criado, R F J, Gregoriou, S, Bobylev, T, Kleinheinz, A, Takahagi, S, Hide, M, Giménez-Arnau, A M, Salman, A, Kara, R Oztas, Dikicier, B S, van Doorn, M B A, Thomsen, S F, van den Reek, J M P A, Röckmann, H

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Atopic dermatitis: disease characteristics and comorbidities in smoking and non‐smoking patients from the TREATgermany registry von Pilz, A.C., Schielein, M.C., Schuster, B., Heinrich, L., Haufe, E., Abraham, S., Heratizadeh, A., Harder, I., Kleinheinz, A., Wollenberg, A., Wiemers, F., Weisshaar, E., Augustin, M., von Kiedrowski, R., Pawlak, M., Schäkel, K., Wildberger, J., Hilgers, M., Werfel, T., Weidinger, S., Schmitt, J., Biedermann, T., Zink, A.

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BASALIT trial: double‐blind placebo‐controlled allergen immunotherapy with rBet v 1‐FV in birch‐related soya allergy von Treudler, R., Franke, A., Schmiedeknecht, A., Ballmer‐Weber, B., Worm, M., Werfel, T., Jappe, U., Biedermann, T., Schmitt, J., Brehler, R., Kleinheinz, A., Kleine‐Tebbe, J., Brüning, H., Ruëff, F., Ring, J., Saloga, J., Schäkel, K., Holzhauser, T., Vieths, S., Simon, J. C.

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Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas von Lopez, Cristina, Schleussner, Nikolai, Bernhart, Stephan H, Kleinheinz, Kortine, Sungalee, Stephanie, Sczakiel, Henrike L, Kretzmer, Helene, Toprak, Umut H, Glaser, Selina, Wagener, Rabea, Ammerpohl, Ole, Bens, Susanne, Giefing, Maciej, Sanchez, Juan C Gonzalez, Apic, Gordana, Hubschmann, Daniel, Janz, Martin, Kreuz, Markus, Mottok, Anja, Muller, Judith M, Seufert, Julian, Hoffmann, Steve, Korbel, Jan O, Russell, Robert B, Schule, Roland, Trumper, Lorenz, Klapper, Wolfram, Radlwimmer, Bernhard, Lichter, Peter, Kuppers, Ralf, Schlesner, Matthias, Mathas, Stephan, Siebert, Reiner

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090 Serum proteomic endotypes are predictive for response to treatment of atopic dermatitis von Hübenthal, M., Emmert, H., Rodriguez, E., Kleinheinz, A., Abraham, S., Handrik, C., Haufe, E., Werfel, T., Schmitt, J., Weidinger, S.

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer von Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

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Targeted degradation via direct 26S proteasome recruitment von Bashore, Charlene, Prakash, Sumit, Johnson, Matthew C., Conrad, Ryan J., Kekessie, Ivy A., Scales, Suzie J., Ishisoko, Noriko, Kleinheinz, Tracy, Liu, Peter S., Popovych, Nataliya, Wecksler, Aaron T., Zhou, Lijuan, Tam, Christine, Zilberleyb, Inna, Srinivasan, Rajini, Blake, Robert A., Song, Aimin, Staben, Steven T., Zhang, Yingnan, Arnott, David, Fairbrother, Wayne J., Foster, Scott A., Wertz, Ingrid E., Ciferri, Claudio, Dueber, Erin C.

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