Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster von Lende, Stine Sofie Frank, Barnkob, Nanna Møller, Hansen, Randi Westh, Bansia, Harsh, Vestergaard, Mike, Rothemejer, Frederik Holm, Worsaae, Anne, Brown, Deijona, Pedersen, Maria Lange, Rahimic, Anna Halling Folkmar, Juhl, Anna Karina, Gjetting, Torben, Østergaard, Lars, Georges, Amédée Des, Vuillard, Laurent-Michel, Schleimann, Mariane Høgsbjerg, Koefoed, Klaus, Tolstrup, Martin

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The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer von Sánchez-Martín, Francisco J, Bellosillo, Beatriz, Gelabert-Baldrich, Mariona, Dalmases, Alba, Cañadas, Israel, Vidal, Joana, Martinez, Alejandro, Argilés, Guillem, Siravegna, Giulia, Arena, Sabrina, Koefoed, Klaus, Visa, Laura, Arpí, Oriol, Horak, Ivan David, Iglesias, Mar, Stroh, Christopher, Kragh, Michael, Rovira, Ana, Albanell, Joan, Tabernero, Josep, Bardelli, Alberto, Montagut, Clara

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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors von Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael

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Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor von Koefoed, Klaus, Steinaa, Lucilla, Søderberg, Josefine Nielsen, Kjær, Ida, Jacobsen, Helle Jane, Meijer, Per-Johan, Haurum, John Sørensen, Jensen, Allan, Kragh, Michael, Andersen, Peter Sejer, Pedersen, Mikkel Wandahl

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Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins von Hazenbos, Wouter L W, Kajihara, Kimberly K, Vandlen, Richard, Morisaki, J Hiroshi, Lehar, Sophie M, Kwakkenbos, Mark J, Beaumont, Tim, Bakker, Arjen Q, Phung, Qui, Swem, Lee R, Ramakrishnan, Satish, Kim, Janice, Xu, Min, Shah, Ishita M, Diep, Binh An, Sai, Tao, Sebrell, Andrew, Khalfin, Yana, Oh, Angela, Koth, Chris, Lin, S Jack, Lee, Byoung-Chul, Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S, Spits, Hergen, Brown, Eric J, Tan, Man-Wah, Mariathasan, Sanjeev

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Reduced Leaflet Motion after Transcatheter Aortic-Valve Replacement von De Backer, Ole, Dangas, George D., Jilaihawi, Hasan, Leipsic, Jonathon A., Terkelsen, Christian J., Makkar, Raj, Kini, Annapoorna S., Veien, Karsten T., Abdel-Wahab, Mohamed, Kim, Won-Keun, Balan, Prakash, Van Mieghem, Nicolas, Mathiassen, Ole N., Jeger, Raban V., Arnold, Martin, Mehran, Roxana, Guimarães, Ana H.C., Nørgaard, Bjarne L., Kofoed, Klaus F., Blanke, Philipp, Windecker, Stephan, Søndergaard, Lars

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Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy von PEDERSEN, Mikkel Wandahl, JACOBSEN, Helle Jane, KOEFOED, Klaus, HEY, Adam, PYKE, Charles, HAURUM, John Sørensen, KRAGH, Michael

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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus von Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer, Darwish, Martine, Lee, Byoung-Chul, Hernandez, Hilda, Loyet, Kelly M., Lupardus, Patrick, Fong, Rina, Yan, Donghong, Chalouni, Cecile, Luis, Elizabeth, Khalfin, Yana, Plise, Emile, Cheong, Jonathan, Lyssikatos, Joseph P., Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S., Flygare, John A., Wah Tan, Man, Brown, Eric J., Mariathasan, Sanjeev

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity von Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan

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Abstract 3822: Characterization of the first chicken-derived anti-PD-1 clinical stage antibody with a unique epitope and promising anticancer activity von Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Melander, Maria C., Galler, Gunther, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D., Kragh, Michael, Pedersen, Mikkel W., Koefoed, Klaus

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Abstract 5629: Preclinical characterization of Sym023 a human anti-TIM3 antibody with a novel mechanism of action von Lindsted, Trine, Gad, Monika, Grandal, Michael V., Frölich, Camilla, Bhatia, Vikram K., Gjetting, Torben, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Koefoed, Klaus, Pedersen, Mikkel W.

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Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance von Pedersen, Mikkel W, Jacobsen, Helle J, Koefoed, Klaus, Dahlman, Anna, Kjær, Ida, Poulsen, Thomas T, Meijer, Per-Johan, Nielsen, Lars S, Horak, Ivan D, Lantto, Johan, Kragh, Michael

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Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms von Grandal, Michael M, Havrylov, Serhiy, Poulsen, Thomas T, Koefoed, Klaus, Dahlman, Anna, Galler, Gunther R, Conrotto, Paolo, Collins, Sara, Eriksen, Karsten W, Kaufman, Dafna, Woude, George F Vande, Jacobsen, Helle J, Horak, Ivan D, Kragh, Michael, Lantto, Johan, Bouquin, Thomas, Park, Morag, Pedersen, Mikkel W

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Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform von Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Lindsted, Trine, Melander, Maria C, Bhatia, Vikram K, Grandal, Michael M, Dietrich, Nikolaj, Uhlenbrock, Franziska, Galler, Gunther R, Strandh, Magnus, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D, Kragh, Michael, Pedersen, Mikkel W, Koefoed, Klaus

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Combination of two anti‐CD5 monoclonal antibodies synergistically induces complement‐dependent cytotoxicity of chronic lymphocytic leukaemia cells von Klitgaard, Josephine L., Koefoed, Klaus, Geisler, Christian, Gadeberg, Ole V., Frank, David A., Petersen, Jørgen, Jurlander, Jesper, Pedersen, Mikkel W.

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Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster von Stine Sofie Frank Lende, Nanna Møller Barnkob, Randi Westh Hansen, Harsh Bansia, Mike Vestergaard, Frederik Holm Rothemejer, Anne Worsaae, Deijona Brown, Maria Lange Pedersen, Anna Halling Folkmar Rahimic, Anna Karina Juhl, Torben Gjetting, Lars Østergaard, Amédée Des Georges, Laurent-Michel Vuillard, Mariane Høgsbjerg Schleimann, Klaus Koefoed, Martin Tolstrup

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Affinity Capture of Biotinylated Proteins at Acidic Conditions to Facilitate Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of Multimeric Protein Complexes von Jensen, Pernille Foged, Jørgensen, Thomas J. D, Koefoed, Klaus, Nygaard, Frank, Sen, Jette Wagtberg

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Combination of two anti‐ CD 5 monoclonal antibodies synergistically induces complement‐dependent cytotoxicity of chronic lymphocytic leukaemia cells von Klitgaard, Josephine L., Koefoed, Klaus, Geisler, Christian, Gadeberg, Ole V., Frank, David A., Petersen, Jørgen, Jurlander, Jesper, Pedersen, Mikkel W.

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Abstract 2149: The anti-EGFR antibody mixture Sym004 overcomes acquired resistance to cetuximab in colorectal cancer von Sanchez-Martin, Francisco J., Dalmases, Alba, Bellosillo, Beatriz, Argiles, Guillem, Gelabert, Mariona, Cañadas, Israel, Vidal, Joana, Siravegna, Giulia, Arena, Sabrina, Koefoed, Klaus, Visa, Laura, Arpí, Oriol, Horak, Ivan D., Iglesias, Mar, Stroh, Christopher, Kragh, Michael, Rovira, Ana, Albanell, Joan, Bardelli, Alberto, Tabernero, Josep, Montagut, Clara

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Abstract 1218: A novel synergistic antibody pair targeting non-overlapping epitopes of MET effectively inhibits MET-driven cancer models von Grandal, Michael M., Poulsen, Thomas T., Koefoed, Klaus, Eriksen, Karsten W., Dahlman, Anna, Conrotto, Paolo, Bouquin, Thomas, Jacobsen, Helle, Horak, Ivan D., Kragh, Michael, Lantto, Johan, Pedersen, Mikkel W.

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