P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping von Acevedo-Rocha, Carlos G, Gamble, Charles G, Lonsdale, Richard, Li, Aitao, Nett, Nathalie, Hoebenreich, Sabrina, Lingnau, Julia B, Wirtz, Cornelia, Fares, Christophe, Hinrichs, Heike, Deege, Alfred, Mulholland, Adrian J, Nov, Yuval, Leys, David, McLean, Kirsty J, Munro, Andrew W, Reetz, Manfred T

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Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium von Belcher, James, McLean, Kirsty J., Matthews, Sarah, Woodward, Laura S., Fisher, Karl, Rigby, Stephen E.J., Nelson, David R., Potts, Donna, Baynham, Michael T., Parker, David A., Leys, David, Munro, Andrew W.

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Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE von Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E.J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.

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Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily von Munro, Andrew W, Girvan, Hazel M, McLean, Kirsty J

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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum von McLean, Kirsty J, Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B, Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W, van den Berg, Marco A

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Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121 von Hudson, Sean A., McLean, Kirsty J., Surade, Sachin, Yang, Yong-Qing, Leys, David, Ciulli, Alessio, Munro, Andrew W., Abell, Chris

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Characterization of Active Site Structure in CYP121: A Cytochrome P450 Essential for Viability of Mycobacterium Tuberculosis H37Rv von McLean, Kirsty J., Carroll, Paul, Lewis, D. Geraint, Dunford, Adrian J., Seward, Harriet E., Neeli, Rajasekhar, Cheesman, Myles R., Marsollier, Laurent, Douglas, Philip, Smith, W. Ewen, Rosenkrands, Ida, Cole, Stewart T., Leys, David, Parish, Tanya, Munro, Andrew W.

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Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode von Seward, Harriet E., Roujeinikova, Anna, McLean, Kirsty J., Munro, Andrew W., Leys, David

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Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3 von Butler, Christopher F, Peet, Caroline, McLean, Kirsty J, Baynham, Michael T, Blankley, Richard T, Fisher, Karl, Rigby, Stephen E J, Leys, David, Voice, Michael W, Munro, Andrew W

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Electron transfer reactions, cyanide and O2 binding of truncated hemoglobin from Bacillus subtilis von Fernandez, Esther, Larsson, Jonas T., McLean, Kirsty J., Munro, Andrew W., Gorton, Lo, von Wachenfeldt, Claes, Ferapontova, Elena E.

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P450 BM3: the very model of a modern flavocytochrome von Munro, Andrew W, Leys, David G, McLean, Kirsty J, Marshall, Ker R, Ost, Tobias W.B, Daff, Simon, Miles, Caroline S, Chapman, Stephen K, Lysek, Dominikus A, Moser, Christopher C, Page, Christopher C, Dutton, P.Leslie

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Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors von Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Smith, Darren, Evans, Jack W.D., Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Levy, Colin W., Munro, Andrew W., Simons, Claire

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FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I von Voss, Ingo, Goss, Tatjana, Murozuka, Emiko, Altmann, Bianca, McLean, Kirsty J., Rigby, Stephen E.J., Munro, Andrew W., Scheibe, Renate, Hase, Toshiharu, Hanke, Guy T.

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Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment von Parsons, Joshua B, Lawrence, Andrew D, McLean, Kirsty J, Munro, Andrew W, Rigby, Stephen E J, Warren, Martin J

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Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species von Collins, Hannah F, Biedendieck, Rebekka, Leech, Helen K, Gray, Michael, Escalante-Semerena, Jorge C, McLean, Kirsty J, Munro, Andrew W, Rigby, Stephen E J, Warren, Martin J, Lawrence, Andrew D

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What makes a P450 tick? von Munro, Andrew W., Girvan, Hazel M., Mason, Amy E., Dunford, Adrian J., McLean, Kirsty J.

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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism von Thistlethwaite, Sian, Jeffreys, Laura N, Girvan, Hazel M, McLean, Kirsty J, Munro, Andrew W

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Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Å Reveals Novel Features of Cytochrome P450 von Leys, David, Mowat, Christopher G, McLean, Kirsty J, Richmond, Alison, Chapman, Stephen K, Walkinshaw, Malcolm D, Munro, Andrew W

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Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes von McLean, Kirsty J, Marshall, Ker R, Richmond, Alison, Hunter, Iain S, Fowler, Kay, Kieser, Tobias, Gurcha, Sudagar S, Besra, Gurydal S, Munro, Andrew W

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Drug targeting of heme proteins in Mycobacterium tuberculosis von McLean, Kirsty J., Munro, Andrew W.

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