Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial von Tutt, Andrew, Tovey, Holly, Cheang, Maggie Chon U., Kernaghan, Sarah, Kilburn, Lucy, Gazinska, Patrycja, Owen, Julie, Abraham, Jacinta, Barrett, Sophie, Barrett-Lee, Peter, Brown, Robert, Chan, Stephen, Dowsett, Mitchell, Flanagan, James M, Fox, Lisa, Grigoriadis, Anita, Gutin, Alexander, Harper-Wynne, Catherine, Hatton, Matthew Q., Hoadley, Katherine A., Parikh, Jyoti, Parker, Peter, Perou, Charles M., Roylance, Rebecca, Shah, Vandna, Shaw, Adam, Smith, Ian E., Timms, Kirsten M., Wardley, Andrew M., Wilson, Gregory, Gillett, Cheryl, Lanchbury, Jerry S., Ashworth, Alan, Rahman, Nazneen, Harries, Mark, Ellis, Paul, Pinder, Sarah E., Bliss, Judith M.

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Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer von Telli, Melinda L, Timms, Kirsten M, Reid, Julia, Hennessy, Bryan, Mills, Gordon B, Jensen, Kristin C, Szallasi, Zoltan, Barry, William T, Winer, Eric P, Tung, Nadine M, Isakoff, Steven J, Ryan, Paula D, Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T, Lanchbury, Jerry S, Hartman, Anne-Renee, Garber, Judy E, Ford, James M, Silver, Daniel P, Richardson, Andrea L

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Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes von Hodgson, Darren R., Dougherty, Brian A., Lai, Zhongwu, Fielding, Anitra, Grinsted, Lynda, Spencer, Stuart, O’Connor, Mark J., Ho, Tony W., Robertson, Jane D., Lanchbury, Jerry S., Timms, Kirsten M., Gutin, Alexander, Orr, Maria, Jones, Helen, Gilks, Blake, Womack, Chris, Gourley, Charlie, Ledermann, Jonathan, Barrett, J. Carl

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Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer von Lotan, Tamara L., Kaur, Harsimar B., Salles, Daniela C., Murali, Sanjana, Schaeffer, Edward M., Lanchbury, Jerry S., Isaacs, William B., Brown, Robert, Richardson, Andrea L., Cussenot, Olivier, Cancel-Tassin, Geraldine, Timms, Kirsten M., Antonarakis, Emmanuel S.

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Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization von Lheureux, Stephanie, Lai, Zhongwu, Dougherty, Brian A, Runswick, Sarah, Hodgson, Darren R, Timms, Kirsten M, Lanchbury, Jerry S, Kaye, Stan, Gourley, Charlie, Bowtell, David, Kohn, Elise C, Scott, Claire, Matulonis, Ursula, Panzarella, Tony, Karakasis, Katherine, Burnier, Julia V, Gilks, C Blake, O'Connor, Mark J, Robertson, Jane D, Ledermann, Jonathan, Barrett, J Carl, Ho, Tony W, Oza, Amit M

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Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer von HENNESSY, Bryan T. J, TIMMS, Kirsten M, YANG LI, JIE LI, GONZALEZ-ANGULO, Ana Maria, MCCUNE, Karen Smith, MARKMAN, Maurie, BROADDUS, Russell R, LANCHBURY, Jerry S, LU, Karen H, MILLS, Gordon B, CAREY, Mark S, GUTIN, Alexander, MEYER, Larissa A, FLAKE, Darl D, ABKEVICH, Victor, POTTER, Jennifer, PRUSS, Dmitry, GLENN, Pat

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Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib von Barnicle, Alan, Ray-Coquard, Isabelle, Rouleau, Etienne, Cadoo, Karen, Simpkins, Fiona, Aghajanian, Carol, Leary, Alexandra, Poveda, Andrés, Lheureux, Stephanie, Pujade-Lauraine, Eric, You, Benoit, Ledermann, Jonathan, Matulonis, Ursula, Gourley, Charlie, Timms, Kirsten M, Lai, Zhongwu, Hodgson, Darren R, Elks, Cathy E, Dearden, Simon, Egile, Coumaran, Lao-Sirieix, Pierre, Harrington, Elizabeth A, Brown, Jessica S

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree von TIMMS, Kirsten M, WAGNER, Susanne, SAMUELS, Mark E, FORBEY, Kristian, GOLDFINE, Howard, JAMMULAPATI, Srikanth, SKOLNICK, Mark H, HOPKINS, Paul N, HUNT, Steve C, SHATTUCK, Donna M

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Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes von Timms, Kirsten M, Abkevich, Victor, Hughes, Elisha, Neff, Chris, Reid, Julia, Morris, Brian, Kalva, Saritha, Potter, Jennifer, Tran, Thanh V, Chen, Jian, Iliev, Diana, Sangale, Zaina, Tikishvili, Eliso, Perry, Michael, Zharkikh, Andrey, Gutin, Alexander, Lanchbury, Jerry S

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Homologous Recombination Deficiency: Concepts, Definitions, and Assays von Stewart, Mark D, Merino Vega, Diana, Arend, Rebecca C, Baden, Jonathan F, Barbash, Olena, Beaubier, Nike, Collins, Grace, French, Tim, Ghahramani, Negar, Hinson, Patsy, Jelinic, Petar, Marton, Matthew J, McGregor, Kimberly, Parsons, Jerod, Ramamurthy, Lakshman, Sausen, Mark, Sokol, Ethan S, Stenzinger, Albrecht, Stires, Hillary, Timms, Kirsten M, Turco, Diana, Wang, Iris, Williams, J Andrew, Wong-Ho, Elaine, Allen, Jeff

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Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis von Valdes, Ana M., Loughlin, John, Timms, Kirsten M., van Meurs, Joyce J.B., Southam, Lorraine, Wilson, Scott G., Doherty, Sally, Lories, Rik J., Luyten, Frank P., Gutin, Alexander, Abkevich, Victor, Ge, Dongliang, Hofman, Albert, Uitterlinden, André G., Hart, Deborah J., Zhang, Feng, Zhai, Guangju, Egli, Rainer J., Doherty, Michael, Lanchbury, Jerry, Spector, Tim D.

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TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer von Isakoff, Steven J, Mayer, Erica L, He, Lei, Traina, Tiffany A, Carey, Lisa A, Krag, Karen J, Rugo, Hope S, Liu, Minetta C, Stearns, Vered, Come, Steven E, Timms, Kirsten M, Hartman, Anne-Renee, Borger, Darrel R, Finkelstein, Dianne M, Garber, Judy E, Ryan, Paula D, Winer, Eric P, Goss, Paul E, Ellisen, Leif W

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Biomarker Assessment of HR Deficiency, Tumor BRCA1/2 Mutations, and CCNE1 Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy von Stronach, Euan A, Paul, James, Timms, Kirsten M, Hughes, Elisha, Brown, Krystal, Neff, Christopher, Perry, Michael, Gutin, Alexander, El-Bahrawy, Mona, Steel, Jennifer H, Liu, Xinxue, Lewsley, Liz-Anne, Siddiqui, Nadeem, Gabra, Hani, Lanchbury, Jerry S, Brown, Robert

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Incidence and Outcome of BRCA Mutations in Unselected Patients with Triple Receptor-Negative Breast Cancer von GONZALEZ-ANGULO, Ana M, TIMMS, Kirsten M, HORTOBAGYI, Gabriel N, DO, Kim-Anh, MILLS, Gordon B, MERIC-BERNSTAM, Funda, SHUYING LIU, HUIQIN CHEN, LITTON, Jennifer K, POTTER, Jennifer, LANCHBURY, Jerry S, STEMKE-HALE, Katherine, HENNESSY, Bryan T, ARUN, Banu K

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Cisplatin with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo-controlled,... von Rodler, Eve, Sharma, Priyanka, Barlow, William E, Gralow, Julie R, Puhalla, Shannon L, Anders, Carey K, Goldstein, Lori, Tripathy, Debu, Brown-Glaberman, Ursa A, Huynh, Thu-Tam, Szyarto, Christopher S, Godwin, Andrew K, Pathak, Harsh B, Swisher, Elizabeth M, Radke, Marc R, Timms, Kirsten M, Lew, Danika L, Miao, Jieling, Pusztai, Lajos, Hayes, Daniel F, Hortobagyi, Gabriel N

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Homologous recombination deficiency (HRD) status predicts response to standard neoadjuvant chemotherapy in patients with triple-negative or BRCA1/2 mutation-associated breast cance... von Telli, Melinda L., Hellyer, Jessica, Audeh, William, Jensen, Kristin C., Bose, Shikha, Timms, Kirsten M., Gutin, Alexander, Abkevich, Victor, Peterson, Rebecca N., Neff, Chris, Hughes, Elisha, Sangale, Zaina, Jones, Joshua, Hartman, Anne-Renee, Chang, Pei-Jen, Vinayak, Shaveta, Wenstrup, Richard, Ford, James M.

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Concordance between an FDA-approved companion diagnostic and an alternative assay kit for assessing homologous recombination deficiency in ovarian cancer von Wehn, Amy K., Qiu, Ping, Lunceford, Jared, Yarunin, Alexander, Cristescu, Razvan, Liu, Li, Roessler, Kyria, Bilke, Sven, Day, John R., Timms, Kirsten M., Weichert, Wilko, Marton, Matthew J.

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Systematic Analysis of Homologous Recombination Deficiency Testing in Ovarian Cancer—Development of Recommendations for Optimal Assay Performance von Romey, Marcel, Rodepeter, Fiona, Hattesohl, Akira, Kaiser, Kristin, Teply-Szymanski, Julia, Heitz, Florian, Staebler, Annette, Serra, Violeta, Grass, Albert, Marmé, Frederik, Timms, Kirsten M., Harter, Philipp, Llop-Guevara, Alba, Kommoss, Stefan, Boekhoff, Jelena, Denkert, Carsten

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Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer von Kalachand, Roshni D., O’Riain, Ciaran, Toomey, Sinead, Carr, Aoife, Timms, Kirsten M., O’Toole, Sharon, Madden, Stephen, Bates, Mark, O’Leary, John J., Gleeson, Noreen, O’Donnell, Dearbhaile, Grogan, Liam, Breathnach, Oscar, Farrelly, Angela, Stordal, Britta, Hennessy, Bryan T.

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Tumor BRCA1 Reversion Mutation Arising during Neoadjuvant Platinum-Based Chemotherapy in Triple-Negative Breast Cancer Is Associated with Therapy Resistance von Afghahi, Anosheh, Timms, Kirsten M, Vinayak, Shaveta, Jensen, Kristin C, Kurian, Allison W, Carlson, Robert W, Chang, Pei-Jen, Schackmann, Elizabeth, Hartman, Anne-Renee, Ford, James M, Telli, Melinda L

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