The evolution of function within the Nudix homology clan von Srouji, John R., Xu, Anting, Park, Annsea, Kirsch, Jack F., Brenner, Steven E.

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PYRIDOXAL PHOSPHATE ENZYMES: Mechanistic, Structural, and Evolutionary Considerations von Eliot, Andrew C, Kirsch, Jack F

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Autoinhibition of Human Dicer by Its Internal Helicase Domain von Ma, Enbo, MacRae, Ian J., Kirsch, Jack F., Doudna, Jennifer A.

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Active site prediction using evolutionary and structural information von Sankararaman, Sriram, Sha, Fei, Kirsch, Jack F., Jordan, Michael I., Sjölander, Kimmen

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Substrate specificity characterization for eight putative nudix hydrolases. Evaluation of criteria for substrate identification within the Nudix family von Nguyen, Vi N., Park, Annsea, Xu, Anting, Srouji, John R., Brenner, Steven E., Kirsch, Jack F.

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Probing the informational and regulatory plasticity of a transcription factor DNA-binding domain von Shultzaberger, Ryan K, Maerkl, Sebastian J, Kirsch, Jack F, Eisen, Michael B

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Identification of functional paralog shift mutations: Conversion of Escherichia coli malate dehydrogenase to a lactate dehydrogenase von Yin, Yifeng, Kirsch, Jack F

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The fitness landscapes of cis-acting binding sites in different promoter and environmental contexts von Shultzaberger, Ryan K, Malashock, Daniel S, Kirsch, Jack F, Eisen, Michael B

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The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity von Aitken, Susan M., Kirsch, Jack F.

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Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT von MCCARTER, John D, STEPHENS, Daren, SHOEMAKER, Kevin, ROSENBERG, Steve, KIRSCH, Jack F, GEORGIOU, George

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How Does an Enzyme Evolved In vitro Compare to Naturally Occurring Homologs Possessing the Targeted Function? Tyrosine Aminotransferase from Aspartate Aminotransferase von Rothman, Steven C., Kirsch, Jack F.

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Defining the Mandate of Proteomics in the Post-Genomics Era: Workshop Report von Kenyon, George L, DeMarini, David M, Fuchs, Elaine, Galas, David J, Kirsch, Jack F, Leyh, Thomas S, Moos, Walter H, Petsko, Gregory A, Ringe, Dagmar, Rubin, Gerald M, Sheahan, Laura C

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Engineering homooligomeric proteins to detect weak intersite allosteric communication: Aminotransferases, a case study von Deu, Edgar, Kirsch, Jack F.

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A continuous fluorescence assay for the characterization of Nudix hydrolases von Xu, Anting, Desai, Anna M., Brenner, Steven E., Kirsch, Jack F.

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The Dual-Specific Active Site of 7,8-Diaminopelargonic Acid Synthase and the Effect of the R391A Mutation von Eliot, Andrew C, Sandmark, Jenny, Schneider, Gunter, Kirsch, Jack F

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Glutamate 47 in 1-Aminocyclopropane-1-carboxylate Synthase Is a Major Specificity Determinant von McCarthy, Darla L, Capitani, Guido, Feng, Liang, Gruetter, Markus G, Kirsch, Jack F

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The Partially Folded Homodimeric Intermediate of Escherichia coli Aspartate Aminotransferase Contains a “Molten Interface” Structure von Deu, Edgar, Dhoot, Jashdeep, Kirsch, Jack F

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Molecular function prediction for a family exhibiting evolutionary tendencies toward substrate specificity swapping: Recurrence of tyrosine aminotransferase activity in the Iα subf... von Muratore, Kathryn E., Engelhardt, Barbara E., Srouji, John R., Jordan, Michael I., Brenner, Steven E., Kirsch, Jack F.

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Molecular function prediction for a family exhibiting evolutionary tendencies toward substrate specificity swapping: Recurrence of tyrosine aminotransferase activity in the I[alpha... von Muratore, Kathryn E, Engelhardt, Barbara E, Srouji, John R, Jordan, Michael I, Brenner, Steven E, Kirsch, Jack F

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Computational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein Interface von Reynolds, Kimberly A., Hanes, Melinda S., Thomson, Jodi M., Antczak, Andrew J., Berger, James M., Bonomo, Robert A., Kirsch, Jack F., Handel, Tracy M.

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