Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer von Kirn, David H., Thorne, Steve H.

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Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer von Heo, Jeong, Reid, Tony, Ruo, Leyo, Breitbach, Caroline J, Rose, Steven, Bloomston, Mark, Cho, Mong, Lim, Ho Yeong, Chung, Hyun Cheol, Kim, Chang Won, Burke, James, Lencioni, Riccardo, Hickman, Theresa, Moon, Anne, Lee, Yeon Sook, Kim, Mi Kyeong, Daneshmand, Manijeh, Dubois, Kara, Longpre, Lara, Ngo, Minhtran, Rooney, Cliona, Bell, John C, Rhee, Byung-Geon, Patt, Richard, Hwang, Tae-Ho, Kirn, David H

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Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells von TAI, Lee-Hwa, DE SOUZA, Christiano Tanese, FALLS, Theresa J, KIRN, David H, BELL, John C, MAKRIGIANNIS, Andrew P, AUER, Rebecca A, BELANGER, Simon, LY, Lundi, ALKAYYAL, Almohanad A, JIQING ZHANG, RINTOUL, Julia L, ANANTH, Abhirami A, LAM, Tiffany, BREITBACH, Caroline J

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First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity von Zeh, Herbert J, Downs-Canner, Stephanie, McCart, J Andrea, Guo, Zong Sheng, Rao, Uma N M, Ramalingam, Lekshmi, Thorne, Stephen H, Jones, Heather L, Kalinski, Pawel, Wieckowski, Eva, O'Malley, Mark E, Daneshmand, Manijeh, Hu, Kang, Bell, John C, Hwang, Tae-Ho, Moon, Anne, Breitbach, Caroline J, Kirn, David H, Bartlett, David L

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The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers von Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Laura, Hu, Kang, Paradis, Francois, Knowles, Shane, Hwang, Tae-Ho, Vanderhyden, Barbara C, Auer, Rebecca, Kirn, David H, Bell, John C

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Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms von Kim, Minah, Nitschké, Maximilian, Sennino, Barbara, Murer, Patrizia, Schriver, Brian J, Bell, Alexander, Subramanian, Aishwarya, McDonald, Corry E, Wang, Jiahu, Cha, Howard, Bourgeois-Daigneault, Marie-Claude, Kirn, David H, Bell, John C, De Silva, Naomi, Breitbach, Caroline J, McDonald, Donald M

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Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus von Kirn, David H, Wang, Yaohe, Le Boeuf, Fabrice, Bell, John, Thorne, Steve H

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Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients von Cripe, Timothy P, Ngo, Minhtran C, Geller, James I, Louis, Chrystal U, Currier, Mark A, Racadio, John M, Towbin, Alexander J, Rooney, Cliona M, Pelusio, Adina, Moon, Anne, Hwang, Tae-Ho, Burke, James M, Bell, John C, Kirn, David H, Breitbach, Caroline J

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VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection von Arulanandam, Rozanne, Batenchuk, Cory, Angarita, Fernando A., Ottolino-Perry, Kathryn, Cousineau, Sophie, Mottashed, Amelia, Burgess, Emma, Falls, Theresa J., De Silva, Naomi, Tsang, Jovian, Howe, Grant A., Bourgeois-Daigneault, Marie-Claude, Conrad, David P., Daneshmand, Manijeh, Breitbach, Caroline J., Kirn, David H., Raptis, Leda, Sad, Subash, Atkins, Harold, Huh, Michael S., Diallo, Jean-Simon, Lichty, Brian D., Ilkow, Carolina S., Le Boeuf, Fabrice, Addison, Christina L., McCart, J. Andrea, Bell, John C.

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Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial von Park, Byeong-Ho, Prof, Hwang, Taeho, MD, Liu, Ta-Chiang, MD, Sze, Daniel Y, MD, Kim, Jae-Seok, MD, Kwon, Hyuk-Chan, MD, Oh, Sung Yong, MD, Han, Sang-Young, Yoon, Jin-Han, MD, Hong, Sook-Hee, MD, Moon, Anne, PhD, Speth, Kelly, BSc, Park, Chohee, BSc, Ahn, Young-Joo, BSc, Daneshmand, Manijeh, MD, Rhee, Byung Geon, PhD, Pinedo, Herbert M, Prof, Bell, John C, Prof, Kirn, David H, Prof

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Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963 von Thorne, Steve H, Hwang, Tae-Ho H, O'Gorman, William E, Bartlett, David L, Sei, Shizuko, Kanji, Femina, Brown, Christopher, Werier, Joel, Cho, Jin-Han, Lee, Dong-Ewon, Wang, Yaohe, Bell, John, Kirn, David H

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Enhancing Poxvirus Oncolytic Effects through Increased Spread and Immune Evasion von KIRN, David H, YAOHE WANG, WENCHUNG LIANG, CONTAG, Christopher H, THORNE, Stephen H

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A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection of ONYX-015 with Intravenous Gemcitabine in Unresectable Pancreatic Carcinoma von HECHT, J. Randolph, BEDFORD, Rudolph, ABBRUZZESE, James L, LAHOTI, Sandeep, REID, Tony R, SOETIKNO, Roy M, KIRN, David H, FREEMAN, Scott M

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Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary pe... von Alberts, David S, Marth, Christian, Alvarez, Ronald D, Johnson, Gary, Bidzinski, Mariusz, Kardatzke, David R, Bradford, Williamson Z, Loutit, Jeff, Kirn, David H, Clouser, Mary C, Markman, Maurie

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A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers von Diallo, Jean-Simon, Boeuf, Fabrice Le, Lai, Frances, Cox, Julie, Vaha-Koskela, Markus, Abdelbary, Hesham, MacTavish, Heather, Waite, Katherine, Falls, Theresa, Wang, Jenny, Brown, Ryan, Blanchard, Jan E, Brown, Eric D, Kirn, David H, Hiscott, John, Atkins, Harry, Lichty, Brian D, Bell, John C

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Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies von Salabarria, Stephanie M, Corti, Manuela, Coleman, Kirsten E, Wichman, Megan B, Berthy, Julie A, D'Souza, Precilla, Tifft, Cynthia J, Herzog, Roland W, Elder, Melissa E, Shoemaker, Lawrence R, Leon-Astudillo, Carmen, Tavakkoli, Fatemeh, Kirn, David H, Schwartz, Jonathan D, Byrne, Barry J

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The Targeted Oncolytic Poxvirus JX-594 Demonstrates Antitumoral, Antivascular, and Anti-HBV Activities in Patients With Hepatocellular Carcinoma von Liu, Ta-Chiang, Hwang, Taeho, Park, Byeong-Ho, Bell, John, Kirn, David H

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Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans von BREITBACH, Caroline J, ARULANANDAM, Rozanne, HEO, Jeong, CHO, Mong, CHEN, Hannah, ANGARITA, Fernando A, ADDISON, Christina, ANDREA MCCART, J, BELL, John C, KIRN, David H, DE SILVA, Naomi, THORNE, Steve H, PATT, Richard, DANESHMAND, Manijeh, MOON, Anne, ILKOW, Carolina, BURKE, James, HWANG, Tae-Ho

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A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular Carcinoma von Breitbach, Caroline J., Moon, Anne, Burke, James, Hwang, Tae-Ho, Kirn, David H.

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Targeted genetic and viral therapy for advanced head and neck cancers von Huang, Pin-I, Chang, Ju-Fang, Kirn, David H., Liu, Ta-Chiang

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