Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors:  From the Active Site to the Second Phosphotyrosine Binding Site von Wilson, Douglas P, Wan, Zhao-Kui, Xu, Wei-Xin, Kirincich, Steven J, Follows, Bruce C, Joseph-McCarthy, Diane, Foreman, Kenneth, Moretto, Alessandro, Wu, Junjun, Zhu, Min, Binnun, Eva, Zhang, Yan-Ling, Tam, May, Erbe, David V, Tobin, James, Xu, Xin, Leung, Louis, Shilling, Adam, Tam, Steve Y, Mansour, Tarek S, Lee, Jinbo

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Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors von Moretto, A.F., Kirincich, S.J., Xu, W.X., Smith, M.J., Wan, Z.-K., Wilson, D.P., Follows, B.C., Binnun, E., Joseph-McCarthy, D., Foreman, K., Erbe, D.V., Zhang, Y.L., Tam, S.K., Tam, S.Y., Lee, J.

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An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1 von Crimmins, Michael T, Katz, Jason D, McAtee, Laura C, Tabet, Elie A, Kirincich, Steven J

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Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylme... von McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D

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Novel risk model for one-year mortality and guidance of management strategy in isolated severe secondary tricuspid regurgitation von Wang, T K M, Mentias, A, Akyuz, K, Kirincich, J, Duran Crane, A, Pettersson, G B, Gillinov, A M, Popovic, Z B, Xu, B, Griffin, B P, Desai, M Y

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Structure-Based Optimization of Protein Tyrosine Phosphatase-1 B Inhibitors: Capturing Interactions with Arginine 24 von Wan, Zhao-Kui, Lee, Jinbo, Hotchandani, Rajeev, Moretto, Alessandro, Binnun, Eva, Wilson, Douglas P., Kirincich, Steve J., Follows, Bruce C., Ipek, Manus, Xu, Weixin, Joseph-McCarthy, Diane, Zhang, Yan-Ling, Tam, May, Erbe, David V., Tobin, James F., Li, Wei, Tam, Steve Y., Mansour, Tarek S., Wu, Junjun

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Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α von LEE, Katherine L, FOLEY, Megan A, KHOR, Soopeang, XIN XU, GOODWIN, Debra G, RAMARAO, Manjunath K, NICKERSON-NUTTER, Cheryl, DONAHUE, Frances, SHERRY KU, M, DARK, James D, MCKEW, John C, CHEN, Lihren, BEHNKE, Mark L, LOVERING, Frank E, KIRINCICH, Steven J, WEIHENG WANG, SHIM, Jaechul, TAM, Steve, SHEN, Marina W. H

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Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties von KIRINCICH, Steven J, JASON XIANG, GREEN, Neal, TAM, Steve, YANG, Hui Y, SHIM, Jaechul, SHEN, Marina W. H, CLARK, James D, MCKEW, John C

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Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α von Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H, Khor, SooPeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D, McKew, John C

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Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling von Erbe, D. V., Klaman, L. D., Wilson, D. P., Wan, Z.-K., Kirincich, S. J., Will, S., Xu, X., Kung, L., Wang, S., Tam, S., Lee, J., Tobin, J. F.

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Asymmetric Total Synthesis of the Caribbean Fruit Fly Pheromone (+)-Epianastrephin von Schultz, Arthur G, Kirincich, Steven J

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An Efficient Preparation and Selected Birch Reduction−Alkylations of 3,4-Dihydro-4,5-dialkyl-2-benzopyran-1-ones von Schultz, Arthur G, Kirincich, Steven J

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Molecular activation of PPARγ by angiotensin II type 1-receptor antagonists von Erbe, David V., Gartrell, Katherine, Zhang, Yan-Ling, Suri, Vipin, Kirincich, Steven J., Will, Sarah, Perreault, Mylene, Wang, Suyue, Tobin, James F.

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Asymmetric organic synthesis. Preparation and birch reduction-alkylation of 2-methyl-3,4-dihydroisoquinolin-1-ones von Schultz, Arthur G, Kirincich, Steven J, Rahm, Rainer

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An Improved Synthetic Preparation of 3-Butenal von Crimmins, Michael T., Kirincich, Steven J., Wells, Angela J., Choy, Allison L.

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Characterization of PTP1b Inhibitors: Development of a Novel ELISA for Insulin Receptor De-Phosphorylation von Yan-Ling, Zhang, Tam, May, Xu, Weixin, Kirincich, Steven J

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Benzhydrylquinazolinediones: Novel cytosolic phospholipase A sub(2) alpha inhibitors with improved physicochemical properties von Kirincich, Steven J, Xiang, Jason, Green, Neal, Tam, Steve, Yang, Hui Y, Shim, Jaechul, Shen, Marina WH, Clark, James D, McKew, John C

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Identification of Novel, Active-Site Inhibitors of PTP1b von Yan-Ling, Zhang, Xu, Weixin, Zhao-Kui, Wan, Kirincich, Steven J

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Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylm... von McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.

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Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha von Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W H, Khor, Soopeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M Sherry, Clark, James D, McKew, John C

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