Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer von Han, Xin, Zhao, Lijie, Xiang, Weiguo, Miao, Bukeyan, Qin, Chong, Wang, Mi, Xu, Tianfeng, McEachern, Donna, Lu, Jianfeng, Wang, Yu, Metwally, Hoda, Yang, Chao-Yie, Kirchhoff, Paul D., Wang, Lu, Matvekas, Aleksas, Takyi-Williams, John, Wen, Bo, Sun, Duxin, Ator, Mark, Mckean, Robert, Wang, Shaomeng

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Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors von Waldschmidt, Helen V, Homan, Kristoff T, Cruz-Rodríguez, Osvaldo, Cato, Marilyn C, Waninger-Saroni, Jessica, Larimore, Kelly M, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y, Kirchhoff, Paul D, Koch, Walter J, Tesmer, John J. G, Larsen, Scott D

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Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents von Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.

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Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors von Waldschmidt, Helen V., Bouley, Renee, Kirchhoff, Paul D., Lee, Pil, Tesmer, John J.G., Larsen, Scott D.

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Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer von Xiang, Weiguo, Zhao, Lijie, Han, Xin, Qin, Chong, Miao, Bukeyan, McEachern, Donna, Wang, Yu, Metwally, Hoda, Kirchhoff, Paul D, Wang, Lu, Matvekas, Aleksas, He, Miao, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence von Zheng, Huiqing, Colvin, Christopher J, Johnson, Benjamin K, Kirchhoff, Paul D, Wilson, Michael, Jorgensen-Muga, Katriana, Larsen, Scott D, Abramovitch, Robert B

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Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia von Kaneshige, Atsunori, Bai, Longchuan, Wang, Mi, McEachern, Donna, Meagher, Jennifer L., Xu, Renqi, Kirchhoff, Paul D., Wen, Bo, Sun, Duxin, Stuckey, Jeanne A., Wang, Shaomeng

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A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo von Kaneshige, Atsunori, Bai, Longchuan, Wang, Mi, McEachern, Donna, Meagher, Jennifer L., Xu, Renqi, Wang, Yu, Jiang, Wei, Metwally, Hoda, Kirchhoff, Paul D., Zhao, Lijie, Jiang, Hui, Wang, Meilin, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A., Wang, Shaomeng

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Identification of Thieno[3,2-b]Pyrrole Derivatives as Novel Small Molecule Inhibitors of Neurotropic Alphaviruses von Peng, Weiping, Peltier, Daniel C., Larsen, Martha J., Kirchhoff, Paul D., Larsen, Scott D., Neubig, Richard R., Miller, David J.

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Discovery of M‑1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression von Zhang, Meng, Aguilar, Angelo, Xu, Shilin, Huang, Liyue, Chinnaswamy, Krishnapriya, Sleger, Taryn, Wang, Bo, Gross, Stefan, Nicolay, Brandon N, Ronseaux, Sebastien, Harvey, Kaitlin, Wang, Yu, McEachern, Donna, Kirchhoff, Paul D, Liu, Zhaomin, Stuckey, Jeanne, Tron, Adriana E, Liu, Tao, Wang, Shaomeng

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Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer von Xiang, Weiguo, Zhao, Lijie, Han, Xin, Xu, Tianfeng, Kregel, Steven, Wang, Mi, Miao, Bukeyan, Qin, Chong, Wang, Mingliang, McEachern, Donna, Lu, Jianfeng, Bai, Longchuan, Yang, Chao-Yie, Kirchhoff, Paul D., Takyi-Williams, John, Wang, Lu, Wen, Bo, Sun, Duxin, Ator, Mark, Mckean, Robert, Chinnaiyan, Arul M., Wang, Shaomeng

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Differences between High- and Low-Affinity Complexes of Enzymes and Nonenzymes von Carlson, Heather A, Smith, Richard D, Khazanov, Nickolay A, Kirchhoff, Paul D, Dunbar, James B, Benson, Mark L

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Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader von Kaneshige, Atsunori, Yang, Yiqing, Bai, Longchuan, Wang, Mi, Xu, Renqi, Mallik, Leena, Chinnaswamy, Krishnapriya, Metwally, Hoda, Wang, Yu, McEachern, Donna, Tošović, Jelena, Yang, Chao-Yie, Kirchhoff, Paul D, Meagher, Jennifer L, Stuckey, Jeanne A, Wang, Shaomeng

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Complementary Cell-Based High-Throughput Screens Identify Novel Modulators of the Unfolded Protein Response von Fribley, Andrew M., Cruz, Patricia G., Miller, Justin R., Callaghan, Michael U., Cai, Peter, Narula, Neha, Neubig, Richard R., Showalter, Hollis D., Larsen, Scott D., Kirchhoff, Paul D., Larsen, Martha J., Burr, Douglas A., Schultz, Pamela J., Jacobs, Renju R., Tamayo-Castillo, Giselle, Ron, David, Sherman, David H., Kaufman, Randal J.

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Rifamycins – Obstacles and opportunities von Aristoff, Paul A, Garcia, George A, Kirchhoff, Paul D, Hollis Showalter, H.D

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Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability von Zwicker, Jeffery D., Diaz, Nicolas A., Guerra, Alfredo J., Kirchhoff, Paul D., Wen, Bo, Sun, Duxin, Carruthers, Vern B., Larsen, Scott D.

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LigScore: a novel scoring function for predicting binding affinities von Krammer, André, Kirchhoff, Paul D., Jiang, X., Venkatachalam, C.M., Waldman, Marvin

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X‑ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins von Molodtsov, Vadim, Nawarathne, Irosha N, Scharf, Nathan T, Kirchhoff, Paul D, Showalter, H. D. Hollis, Garcia, George A, Murakami, Katsuhiko S

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Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity von Kapuria, Vaibhav, Peterson, Luke F., Showalter, H.D. Hollis, Kirchhoff, Paul D., Talpaz, Moshe, Donato, Nicholas J.

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Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo von Delekta, Phillip C, Dobry, Craig J, Sindac, Janice A, Barraza, Scott J, Blakely, Pennelope K, Xiang, Jianming, Kirchhoff, Paul D, Keep, Richard F, Irani, David N, Larsen, Scott D, Miller, David J

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