Transition states of native and drug-resistant HIV-1 protease are the same von Kipp, D. Randal, Hirschi, Jennifer S, Wakata, Aya, Goldstein, Harris, Schramm, Vern L

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 von Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, Yu, Jianjun, McAllister, Gregg, Stump, Mark, deBeaumont, Rosalie, Ho, Samuel, Yue, Yingzi, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, D. Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Zheng, Bing, Lin, Ying, Cho, Young Shin, Gu, Justin, Crawford, Kenneth, Ciccone, David, Vitari, Alberto C., Lai, Albert, Capka, Vladimir, Hurov, Kristen, Porter, Jeffery A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.

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Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors von Taylor, Alexander M., Williams, Bret R., Giordanetto, Fabrizio, Kelley, Elizabeth H., Lescarbeau, André, Shortsleeves, Kelley, Tang, Yong, Walters, W. Patrick, Arrazate, Alfonso, Bowman, Christine, Brophy, Erin, Chan, Emily W., Deshmukh, Gauri, Greisman, Jack B., Hunsaker, Thomas L., Kipp, D. Randal, Saenz Lopez-Larrocha, Pablo, Maddalo, Danilo, Martin, Iain J., Maragakis, Paul, Merchant, Mark, Murcko, Mark, Nisonoff, Hunter, Nguyen, Vi, Nguyen, Vy, Orozco, Olivia, Owen, Christopher, Pierce, Levi, Schmidt, Molly, Shaw, David E., Smith, Sherri, Therrien, Eric, Tran, John C., Watters, Jim, Waters, Nigel J., Wilbur, Jeremy, Willmore, Lindsay

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Mass-Dependent Bond Vibrational Dynamics Influence Catalysis by HIV-1 Protease von Kipp, D. Randal, Silva, Rafael G, Schramm, Vern L

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Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia von Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal

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Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein von Fonte, Virginia, Kipp, D. Randal, Yerg, John, Merin, David, Forrestal, Margaret, Wagner, Eileen, Roberts, Christine M., Link, Christopher D.

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Enzyme-Dependent Lysine Deprotonation in EZH2 Catalysis von Kipp, D. Randal, Quinn, Christopher M, Fortin, Pascal D

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Constrained Bonding Environment in the Michaelis Complex of Trypanosoma cruzi Uridine Phosphorylase von Silva, Rafael G, Kipp, D. Randal, Schramm, Vern L

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The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70 von Hassan, A. Quamrul, Kirby, Christina A., Zhou, Wenlai, Schuhmann, Tim, Kityk, Roman, Kipp, D. Randal, Baird, Jason, Chen, Jinyun, Chen, Yaoyu, Chung, Franklin, Hoepfner, Dominic, Movva, N. Rao, Pagliarini, Raymond, Petersen, Frank, Quinn, Christopher, Quinn, Douglas, Riedl, Ralph, Schmitt, Esther K., Schitter, Anne, Stams, Travis, Studer, Christian, Fortin, Pascal D., Mayer, Matthias P., Sadlish, Heather

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Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein von Virginia Fonte, D. Randal Kipp, John Yerg III, David Merin, Margaret Forrestal, Eileen Wagner, Christine M. Roberts, Christopher D. Link

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The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70 von Hassan, A. Quamrul, Kirby, Christina A., Zhou, Wenlai, Schuhmann, Tim, Kityk, Roman, Kipp, D. Randal, Baird, Jason, Chen, Jinyun, Chen, Yaoyu, Chung, Franklin, Hoepfner, Dominic, Movva, N. Rao, Pagliarini, Raymond, Petersen, Frank, Quinn, Christopher, Quinn, Douglas, Riedl, Ralph, Schmitt, Esther K., Schitter, Anne, Stams, Travis, Studer, Christian, Fortin, Pascal D., Mayer, Matthias P., Sadlish, Heather

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