SomaLogic proteomics reveals new biomarkers and provides mechanistic, clinical insights into Acetyl coA Carboxylase (ACC) inhibition in Non-alcoholic Steatohepatitis (NASH) von Sivakumar, Pitchumani, Saul, Michelle, Robinson, Douglas, King, Lindsay E., Amin, Neeta B.

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data von Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert

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Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin von Betts, Alison M., Haddish-Berhane, Nahor, Tolsma, John, Jasper, Paul, King, Lindsay E., Sun, Yongliang, Chakrapani, Subramanyam, Shor, Boris, Boni, Joseph, Johnson, Theodore R.

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Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1) von Singh, Aman P., Maass, Katie F., Betts, Alison M., Wittrup, K. Dane, Kulkarni, Chethana, King, Lindsay E., Khot, Antari, Shah, Dhaval K.

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Parallelism experiments in biomarker ligand-binding assays to assess immunological similarity von King, Lindsay E

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Bioanalytical Approaches to Quantify “Total” and “Free” Therapeutic Antibodies and Their Targets: Technical Challenges and PK/PD Applications Over the Course of Drug Development... von Lee, Jean W., Kelley, Marian, King, Lindsay E., Yang, Jihong, Salimi-Moosavi, Hossein, Tang, Meina T., Lu, Jian-Feng, Kamerud, John, Ahene, Ago, Myler, Heather, Rogers, Cindy

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Mass cytometry for the multiplexed quantification and characterization of target expression on circulating cells in whole blood von Stevens, Chad R., Atkuri, Kondala, Menard, Daniele L., King, Lindsay E., Neubert, Hendrik, Goihberg, Polina

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers von Mathur, Divya, Root, Adam R., Bugaj-Gaweda, Bozena, Bisulco, Stephanie, Tan, Xingzhi, Fang, Wei, Kearney, Jessica C., Lucas, Justin, Guffroy, Magali, Golas, Jonathan, Rohde, Cynthia M., Stevens, Chad, Kamperschroer, Cris, Kelleher, Kerry, Lawrence-Henderson, Rosemary F., Upeslacis, Erik, Yao, Johnny, Narula, Jatin, LaVallie, Edward R., Fernandez, Diane R., Buetow, Bernard S., Rosfjord, Edward, Bloom, Laird, King, Lindsay E., Tchistiakova, Lioudmila, Nguyen, Anhco, Sapra, Puja

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Ligand Binding Assay Critical Reagents and Their Stability: Recommendations and Best Practices from the Global Bioanalysis Consortium Harmonization Team von King, Lindsay E., Farley, Esme, Imazato, Mami, Keefe, Jeannine, Khan, Masood, Ma, Mark, Pihl, K. Susanne, Sriraman, Priya

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Theoretical Considerations and Practical Approaches to Address the Effect of Anti-drug Antibody (ADA) on Quantification of Biotherapeutics in Circulation von Kelley, Marian, Ahene, Ago B., Gorovits, Boris, Kamerud, John, King, Lindsay E., McIntosh, Thomas, Yang, Jihong

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Practical quantitative and kinetic applications of bio-layer interferometry for toxicokinetic analysis of a monoclonal antibody therapeutic von Dysinger, Mark, King, Lindsay E.

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Antibody–Drug Conjugates Nonclinical Support: from Early to Late Nonclinical Bioanalysis Using Ligand-Binding Assays von Kumar, Seema, King, Lindsay E, Clark, Tracey H, Gorovits, Boris

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A Priori Prediction of Tumor Payload Concentrations: Preclinical Case Study with an Auristatin-Based Anti-5T4 Antibody-Drug Conjugate von Shah, Dhaval K., King, Lindsay E., Han, Xiaogang, Wentland, Jo-Ann, Zhang, Yanhua, Lucas, Judy, Haddish-Berhane, Nahor, Betts, Alison, Leal, Mauricio

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Feasibility of Singlet Analysis for Ligand Binding Assays: a Retrospective Examination of Data Generated Using the Gyrolab Platform von Clark, Tracey H., Yates, Phillip D., Chunyk, Allison Given, Joyce, Alison P., Wu, Aidong, Pop-Damkov, Petar, Zhang, Yiqun, Dreher, Elizabeth A., Tylaska, Laurie A., Wentland, Jo-Ann A., Pelletier, Kathleen B., King, Lindsay E., Ray, Chad A.

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Discovery Fit-For-Purpose Ligand-Binding PK Assays: What’s Really Important? von King, Lindsay E, Leung, Sheldon, Ray, Chad

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Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies von Simon, Tracey G., King, Lindsay Y., Chong, Dawn Q., Nguyen, Long H., Ma, Yanan, VoPham, Trang, Giovannucci, Edward L., Fuchs, Charles S., Meyerhardt, Jeffrey A., Corey, Kathleen E., Khalili, Hamed, Chung, Raymond T., Zhang, Xuehong, Chan, Andrew T.

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Analysis of vitamin A and retinoids in biological matrices von Czuba, Lindsay C., Zhong, Guo, Yabut, King C., Isoherranen, Nina

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Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue following Stroke, 6th edition update 2019 von Lanctôt, Krista L, Lindsay, M Patrice, Smith, Eric E, Sahlas, Demetrios J, Foley, Norine, Gubitz, Gord, Austin, Melissa, Ball, Kristyn, Bhogal, Sanjit, Blake, Treena, Herrmann, Nathan, Hogan, David, Khan, Aisha, Longman, Stewart, King, Andrea, Leonard, Carol, Shoniker, Tricia, Taylor, Trudy, Teed, Moira, de Jong, Andrea, Mountain, Anita, Casaubon, Leanne K, Dowlatshahi, Dar, Swartz, Richard H

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Absence of Heterozygosity Due to Template Switching during Replicative Rearrangements von Carvalho, Claudia M.B., Pfundt, Rolph, King, Daniel A., Lindsay, Sarah J., Zuccherato, Luciana W., Macville, Merryn V.E., Liu, Pengfei, Johnson, Diana, Stankiewicz, Pawel, Brown, Chester W., Shaw, Chad A., Hurles, Matthew E., Ira, Grzegorz, Hastings, P.J., Brunner, Han G., Lupski, James R.

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Optimizing landscape selection for estimating relative effects of landscape variables on ecological responses von Pasher, Jon, Mitchell, Scott W., King, Douglas J., Fahrig, Lenore, Smith, Adam C., Lindsay, Kathryn E.

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