Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity von Mabanglo, Mark F., Wilson, Brian, Noureldin, Mahmoud, Kimani, Serah W., Mamai, Ahmed, Krausser, Chiara, González-Álvarez, Héctor, Srivastava, Smriti, Mohammed, Mohammed, Hoffer, Laurent, Chan, Manuel, Avrumutsoae, Jamie, Li, Alice Shi Ming, Hajian, Taraneh, Tucker, Sarah, Green, Stuart, Szewczyk, Magdalena, Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Ackloo, Suzanne, Loppnau, Peter, Li, Yanjun, Seitova, Almagul, Kiyota, Taira, Wang, Jue George, Privé, Gilbert G., Kuntz, Douglas A., Patel, Bhashant, Rathod, Vaibhavi, Vala, Anand, Rout, Bhimsen, Aman, Ahmed, Poda, Gennady, Uehling, David, Ramnauth, Jailall, Halabelian, Levon, Marcellus, Richard, Al-awar, Rima, Vedadi, Masoud

Volltext

The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition von Kimani, Serah W., Perveen, Sumera, Szewezyk, Magdalena, Zeng, Hong, Dong, Aiping, Li, Fengling, Ghiabi, Pegah, Li, Yanjun, Chau, Irene, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Halabelian, Levon

Volltext

A ligand discovery toolbox for the WWE domain family of human E3 ligases von Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark

Volltext

Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets von Kimani, Serah W., Owen, Julie, Green, Stuart R., Li, Fengling, Li, Yanjun, Dong, Aiping, Brown, Peter J., Ackloo, Suzanne, Kuter, David, Yang, Cindy, MacAskill, Miranda, MacKinnon, Stephen Scott, Arrowsmith, Cheryl H., Schapira, Matthieu, Shahani, Vijay, Halabelian, Levon

Volltext

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins von Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Xu, Jin, Ahmad, Shabbir, Arnautova, Yelena A, Baghaie, A. J., Beldar, Serap, Bolotokova, Albina, Centrella, Paolo A., Chau, Irene, Clark, Matthew A., Cuozzo, John W., Dehghani-Tafti, Saba, Disch, Jeremy S., Dong, Aiping, Dumas, Antoine, Feng, Jianwen A., Ghiabi, Pegah, Gibson, Elisa, Gilmer, Justin, Goldman, Brian, Green, Stuart R, Guié, Marie-Aude, Guilinger, John P., Harms, Nathan, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kearnes, Steven, Keefe, Anthony D., Kimani, Serah W., Kramer, Trevor, Kutera, Maria, Kwak, Haejin A., Lento, Cristina, Li, Yanjun, Liu, Jenny, Loup, Joachim, Machado, Raquel A. C., Mulhern, Christopher J., Perveen, Sumera, Righetto, Germanna L., Riley, Patrick, Shrestha, Suman, Sigel, Eric A., Silva, Madhushika, Sintchak, Michael D., Slakman, Belinda L., Taylor, Rhys D., Thompson, James, Torng, Wen, Underkoffler, Carl, von Rechenberg, Moritz, Walsh, Ryan T., Watson, Ian, Wilson, Derek J., Wolf, Esther, Yadav, Manisha, Yazdi, Aliakbar K., Zhang, Junyi, Zhang, Ying, Santhakumar, Vijayaratnam, Edwards, Aled M., Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J., Halabelian, Levon, Arrowsmith, Cheryl H.

Volltext

The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning von Weber, Brandon W, Kimani, Serah W, Varsani, Arvind, Cowan, Donald A, Hunter, Roger, Venter, Gerhard A, Gumbart, James C, Sewell, B Trevor

Volltext

Structure of an aliphatic amidase from Geobacillus pallidus RAPc8 von Kimani, Serah W., Agarkar, Vinod B., Cowan, Donald A., Sayed, Muhammed F.-R., Sewell, B. Trevor

Volltext

The quaternary structure of the amidase from Geobacillus pallidus RAPc8 is revealed by its crystal packing von Agarkar, Vinod B., Kimani, Serah W., Cowan, Donald A., Sayed, Muhammed F.-R., Sewell, B. Trevor

Volltext

The Mechanism of the Amidases von Weber, Brandon W., Kimani, Serah W., Varsani, Arvind, Cowan, Donald A., Hunter, Roger, Venter, Gerhard A., Gumbart, James C., Sewell, B. Trevor

Volltext

Discovery of Nanomolar DCAF1 Small Molecule Ligands von Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud

Volltext

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa von Ochong, Edwin, Nzila, Alexis, Kimani, Serah, Kokwaro, Gilbert, Mutabingwa, Theonest, Watkins, William, Marsh, Kevin

Volltext