Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells von Fenwick, Peter S, Macedo, Patricia, Kilty, Iain C, Barnes, Peter J, Donnelly, Louise E

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of In... von Lee, Katherine L, Ambler, Catherine M, Anderson, David R, Boscoe, Brian P, Bree, Andrea G, Brodfuehrer, Joanne I, Chang, Jeanne S, Choi, Chulho, Chung, Seungwon, Curran, Kevin J, Day, Jacqueline E, Dehnhardt, Christoph M, Dower, Ken, Drozda, Susan E, Frisbie, Richard K, Gavrin, Lori K, Goldberg, Joel A, Han, Seungil, Hegen, Martin, Hepworth, David, Hope, Heidi R, Kamtekar, Satwik, Kilty, Iain C, Lee, Arthur, Lin, Lih-Ling, Lovering, Frank E, Lowe, Michael D, Mathias, John P, Morgan, Heidi M, Murphy, Elizabeth A, Papaioannou, Nikolaos, Patny, Akshay, Pierce, Betsy S, Rao, Vikram R, Saiah, Eddine, Samardjiev, Ivan J, Samas, Brian M, Shen, Marina W. H, Shin, Julia H, Soutter, Holly H, Strohbach, Joseph W, Symanowicz, Peter T, Thomason, Jennifer R, Trzupek, John D, Vargas, Richard, Vincent, Fabien, Yan, Jiangli, Zapf, Christoph W, Wright, Stephen W

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Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease von Millan, David S, Bunnage, Mark E, Burrows, Jane L, Butcher, Kenneth J, Dodd, Peter G, Evans, Timothy J, Fairman, David A, Hughes, Samantha J, Kilty, Iain C, Lemaitre, Arnaud, Lewthwaite, Russell A, Mahnke, Axel, Mathias, John P, Philip, James, Smith, Robert T, Stefaniak, Mark H, Yeadon, Michael, Phillips, Christopher

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Fragment based discovery of a novel and selective PI3 kinase inhibitor von Hughes, Samantha J., Millan, David S., Kilty, Iain C., Lewthwaite, Russell A., Mathias, John P., O’Reilly, Mark A., Pannifer, Andrew, Phelan, Anne, Stühmeier, Frank, Baldock, Darren A., Brown, David G.

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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD von Bewley, Martin A, Belchamber, Kylie B R, Chana, Kirandeep K, Budd, Richard C, Donaldson, Gavin, Wedzicha, Jadwiga A, Brightling, Christopher E, Kilty, Iain, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists von Bewley, Martin A, Budd, Richard C, Ryan, Eilise, Cole, Joby, Collini, Paul, Marshall, Jennifer, Kolsum, Umme, Beech, Gussie, Emes, Richard D, Tcherniaeva, Irina, Berbers, Guy A M, Walmsley, Sarah R, Donaldson, Gavin, Wedzicha, Jadwiga A, Kilty, Iain, Rumsey, William, Sanchez, Yolanda, Brightling, Christopher E, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

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The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro von Miller, Suzanne, Henry, Amanda P, Hodge, Emily, Kheirallah, Alexander K, Billington, Charlotte K, Rimington, Tracy L, Bhaker, Sangita K, Obeidat, Ma'en, Melén, Erik, Merid, Simon K, Swan, Caroline, Gowland, Catherine, Nelson, Carl P, Stewart, Ceri E, Bolton, Charlotte E, Kilty, Iain, Malarstig, Anders, Parker, Stuart G, Moffatt, Miriam F, Wardlaw, Andrew J, Hall, Ian P, Sayers, Ian

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Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF‐κB activation and proinflammatory cytokine release in alveolar epithelial cells von Moodie, Fiona M., Marwick, John A., Anderson, Charlotte S., Szulakowski, Patryk, Biswas, Saibal K., Bauter, Mark R., Kilty, Iain, Rahman, Irfan

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Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid [version 1; peer review: 2 approved] von Rimington, Tracy L, Hodge, Emily, Billington, Charlotte K, Bhaker, Sangita, K C, Binaya, Kilty, Iain, Jelinsky, Scott, Hall, Ian P, Sayers, Ian

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Cigarette smoke induced airway inflammation is independent of NF-κB signalling von Rastrick, Joseph M D, Stevenson, Christopher S, Eltom, Suffwan, Grace, Megan, Davies, Meirion, Kilty, Iain, Evans, Steven M, Pasparakis, Manolis, Catley, Matthew C, Lawrence, Toby, Adcock, Ian M, Belvisi, Maria G, Birrell, Mark A

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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists von Bewley, Martin A, Tcherniaeva, Irina, Berbers, Guy A M, Walmsley, Sarah R, Donaldson, Gavin, Wedzicha, Jadwiga A, Kilty, Iain, Rumsey, William, Sanchez, Yolanda, Brightling, Christopher E, Donnelly, Louise E, Budd, Richard C, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H, Ryan, Eilise, Cole, Joby, Collini, Paul, Marshall, Jennifer, Kolsum, Umme, Beech, Gussie, Emes, Richard D

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Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists von Bewley, Martin A, Budd, Richard C, Ryan, Eilise, Cole, Joby, Collini, Paul, Marshall, J, Kolsum, Umme, Beech, Gussie, Emes, Richard D, Tcherniaeva, Irina, Berbers, Guy A.M, Walmsley, Sarah R, Donaldson, Gavin, Wedzicha, Jadwiga A, Kilty, Iain, Rumsey, William, Sanchez, Yolanda, Brightling, Christopher, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

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Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling von Rastrick, Joseph M. D., Stevenson, Christopher S., Eltom, Suffwan, Grace, Megan, Davies, Meirion, Kilty, Iain, Evans, Steven M., Pasparakis, Manolis, Catley, Matthew C., Lawrence, Toby, Adcock, Ian M., Belvisi, Maria G., Birrell, Mark A.

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Cigarette Smoke Induced Airway Inflammation Is Independent of NF-[kappa]B Signalling von Rastrick, Joseph M. D, Stevenson, Christopher S, Eltom, Suffwan, Grace, Megan, Davies, Meirion, Kilty, Iain, Evans, Steven M, Pasparakis, Manolis, Catley, Matthew C, Lawrence, Toby, Adcock, Ian M, Belvisi, Maria G, Birrell, Mark A

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Gene Expression and Immunolocalization of 15-Lipoxygenase Isozymes in the Airway Mucosa of Smokers with Chronic Bronchitis von Zhu, Jie, Kilty, Iain, Granger, Helen, Gamble, Elizabeth, Qiu, Yu Sheng, Hattotuwa, Keith, Elston, Will, Liu, Wai L, Oliva, Alessandro, Pauwels, Romain A, Kips, Johan C, De Rose, Virginia, Barnes, Neil, Yeadon, Michael, Jenkinson, Stephen, Jeffery, Peter K

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