Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening von Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P, Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura, Straub, Verena M, Szommer, Tamas, Velupillai, Srikannathasan, Zaidman, Daniel, Zhang, Yanling, Coker, Alun R, Dowson, Christopher G, Barr, Haim M, Wang, Chu, Huber, Kilian V.M, Brennan, Paul E, Ovaa, Huib, von Delft, Frank, London, Nir

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Importance of Quantifying Drug-Target Engagement in Cells von Stefaniak, Jakub, Huber, Kilian V. M

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Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b‑AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Accepto... von Ward, Jennifer A, Pinto-Fernandez, Adan, Cornelissen, Loïc, Bonham, Sarah, Díaz-Sáez, Laura, Riant, Olivier, Huber, Kilian V. M, Kessler, Benedikt M, Feron, Olivier, Tate, Edward W

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Discovery of an MLLT1/3 YEATS Domain Chemical Probe von Moustakim, Moses, Christott, Thomas, Monteiro, Octovia P., Bennett, James, Giroud, Charline, Ward, Jennifer, Rogers, Catherine M., Smith, Paul, Panagakou, Ioanna, Díaz‐Sáez, Laura, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Halidi, Nadia, Heidenreich, David, Chaikuad, Apirat, Knapp, Stefan, Huber, Kilian V. M., Farnie, Gillian, Heer, Jag, Manevski, Nenad, Poda, Gennady, Al‐awar, Rima, Dixon, Darren J., Brennan, Paul E., Fedorov, Oleg

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A chemical biology toolbox to study protein methyltransferases and epigenetic signaling von Scheer, Sebastian, Ackloo, Suzanne, Medina, Tiago S., Schapira, Matthieu, Li, Fengling, Ward, Jennifer A., Lewis, Andrew M., Northrop, Jeffrey P., Richardson, Paul L., Kaniskan, H. Ümit, Shen, Yudao, Liu, Jing, Smil, David, McLeod, David, Zepeda-Velazquez, Carlos A., Luo, Minkui, Jin, Jian, Barsyte-Lovejoy, Dalia, Huber, Kilian V. M., De Carvalho, Daniel D., Vedadi, Masoud, Zaph, Colby, Brown, Peter J., Arrowsmith, Cheryl H.

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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action von Babak, Maria V, Meier, Samuel M, Huber, Kilian V M, Reynisson, Jóhannes, Legin, Anton A, Jakupec, Michael A, Roller, Alexander, Stukalov, Alexey, Gridling, Manuela, Bennett, Keiryn L, Colinge, Jacques, Berger, Walter, Dyson, Paul J, Superti-Furga, Giulio, Keppler, Bernhard K, Hartinger, Christian G

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The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity von Winter, Georg E, Radic, Branka, Mayor-Ruiz, Cristina, Blomen, Vincent A, Trefzer, Claudia, Kandasamy, Richard K, Huber, Kilian V M, Gridling, Manuela, Chen, Doris, Klampfl, Thorsten, Kralovics, Robert, Kubicek, Stefan, Fernandez-Capetillo, Oscar, Brummelkamp, Thijn R, Superti-Furga, Giulio

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A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function von Fagan, Vincent, Johansson, Catrine, Gileadi, Carina, Monteiro, Octovia, Dunford, James E, Nibhani, Reshma, Philpott, Martin, Malzahn, Jessica, Wells, Graham, Faram, Ruth, Cribbs, Adam P, Halidi, Nadia, Li, Fengling, Chau, Irene, Greschik, Holger, Velupillai, Srikannathasan, Allali-Hassani, Abdellah, Bennett, James, Christott, Thomas, Giroud, Charline, Lewis, Andrew M, Huber, Kilian V. M, Athanasou, Nick, Bountra, Chas, Jung, Manfred, Schüle, Roland, Vedadi, Masoud, Arrowsmith, Cheryl, Xiong, Yan, Jin, Jian, Fedorov, Oleg, Farnie, Gillian, Brennan, Paul E, Oppermann, Udo

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design von Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function von Coleman, Oliver D, Macdonald, Jessica, Thomson, Ben, Ward, Jennifer A, Stubbs, Christopher J, McAllister, Tom E, Clark, Shane, Amin, Siddique, Cao, Yimang, Abboud, Martine I, Zhang, Yijia, Sanganee, Hitesh, Huber, Kilian V. M, Claridge, Tim D. W, Kawamura, Akane

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy von Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio

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Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes von Rothweiler, Elisabeth M., Huber, Kilian V. M.

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Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia von Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V M, Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J, Zuber, Johannes, Bennett, Keiryn L, Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H, Superti-Furga, Giulio

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Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains von Bouché, Léa, Christ, Clara D, Siegel, Stephan, Fernández-Montalván, Amaury E, Holton, Simon J, Fedorov, Oleg, ter Laak, Antonius, Sugawara, Tatsuo, Stöckigt, Detlef, Tallant, Cynthia, Bennett, James, Monteiro, Octovia, Díaz-Sáez, Laura, Siejka, Paulina, Meier, Julia, Pütter, Vera, Weiske, Jörg, Müller, Susanne, Huber, Kilian V. M, Hartung, Ingo V, Haendler, Bernard

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Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions von Ji, Hongchao, Lu, Xue, Zhao, Shiji, Wang, Qiqi, Liao, Bin, Bauer, Ludwig G., Huber, Kilian V.M., Luo, Ray, Tian, Ruijun, Tan, Chris Soon Heng

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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators von Rothweiler, Elisabeth M., Brennan, Paul E., Huber, Kilian V. M.

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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3 von Böttcher, Jark, Dilworth, David, Reiser, Ulrich, Neumüller, Ralph A., Schleicher, Michael, Petronczki, Mark, Zeeb, Markus, Mischerikow, Nikolai, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Li, Fengling, Kennedy, Steven, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Brown, Peter J., Huber, Kilian V. M., Rogers, Catherine M., Wells, Carrow I., Fedorov, Oleg, Rumpel, Klaus, Zoephel, Andreas, Mayer, Moriz, Wunberg, Tobias, Böse, Dietrich, Zahn, Stephan, Arnhof, Heribert, Berger, Helmut, Reiser, Christoph, Hörmann, Alexandra, Krammer, Teresa, Corcokovic, Maja, Sharps, Bernadette, Winkler, Sandra, Häring, Daniela, Cockcroft, Xiao-Ling, Fuchs, Julian E., Müllauer, Barbara, Weiss-Puxbaum, Alexander, Gerstberger, Thomas, Boehmelt, Guido, Vakoc, Christopher R., Arrowsmith, Cheryl H., Pearson, Mark, McConnell, Darryl B.

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Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia von Mackinnon, Sabrina R, Krojer, Tobias, Foster, William R, Diaz-Saez, Laura, Tang, Manshu, Huber, Kilian V. M, von Delft, Frank, Lai, Kent, Brennan, Paul E, Arruda Bezerra, Gustavo, Yue, Wyatt W

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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk von Sdelci, Sara, Lardeau, Charles-Hugues, Tallant, Cynthia, Klepsch, Freya, Klaiber, Björn, Bennett, James, Rathert, Philipp, Schuster, Michael, Penz, Thomas, Fedorov, Oleg, Superti-Furga, Giulio, Bock, Christoph, Zuber, Johannes, Huber, Kilian V M, Knapp, Stefan, Müller, Susanne, Kubicek, Stefan

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Discovery of a PCAF Bromodomain Chemical Probe von Moustakim, Moses, Clark, Peter G. K., Trulli, Laura, Fuentes de Arriba, Angel L., Ehebauer, Matthias T., Chaikuad, Apirat, Murphy, Emma J., Mendez‐Johnson, Jacqui, Daniels, Danette, Hou, Chun‐Feng D., Lin, Yu‐Hui, Walker, John R., Hui, Raymond, Yang, Hongbing, Dorrell, Lucy, Rogers, Catherine M., Monteiro, Octovia P., Fedorov, Oleg, Huber, Kilian V. M., Knapp, Stefan, Heer, Jag, Dixon, Darren J., Brennan, Paul E.

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