Apoptosis in megakaryocytes and platelets: the life and death of a lineage von McArthur, Kate, Chappaz, Stephane, Kile, Benjamin T.

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production von White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells von Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis von McArthur, Kate, Whitehead, Lachlan W, Heddleston, John M, Li, Lucy, Padman, Benjamin S, Oorschot, Viola, Geoghegan, Niall D, Chappaz, Stephane, Davidson, Sophia, San Chin, Hui, Lane, Rachael M, Dramicanin, Marija, Saunders, Tahnee L, Sugiana, Canny, Lessene, Romina, Osellame, Laura D, Chew, Teng-Leong, Dewson, Grant, Lazarou, Michael, Ramm, Georg, Lessene, Guillaume, Ryan, Michael T, Rogers, Kelly L, van Delft, Mark F, Kile, Benjamin T

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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells von Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic

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IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome von Murphy, Andrew J., Kraakman, Michael J., Kammoun, Helene L., Dragoljevic, Dragana, Lee, Man K.S., Lawlor, Kate E., Wentworth, John M., Vasanthakumar, Ajithkumar, Gerlic, Motti, Whitehead, Lachlan W., DiRago, Ladina, Cengia, Louise, Lane, Rachael M., Metcalf, Donald, Vince, James E., Harrison, Leonard C., Kallies, Axel, Kile, Benjamin T., Croker, Ben A., Febbraio, Mark A., Masters, Seth L.

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Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals von Chirn, Gung-Wei, Rahman, Reazur, Sytnikova, Yuliya A, Matts, Jessica A, Zeng, Mei, Gerlach, Daniel, Yu, Michael, Berger, Bonnie, Naramura, Mayumi, Kile, Benjamin T, Lau, Nelson C

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Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically von Putoczki, Tracy L., Thiem, Stefan, Loving, Andrea, Busuttil, Rita A., Wilson, Nicholas J., Ziegler, Paul K., Nguyen, Paul M., Preaudet, Adele, Farid, Ryan, Edwards, Kirsten M., Boglev, Yeliz, Luwor, Rodney B., Jarnicki, Andrew, Horst, David, Boussioutas, Alex, Heath, Joan K., Sieber, Oliver M., Pleines, Irina, Kile, Benjamin T., Nash, Andrew, Greten, Florian R., McKenzie, Brent S., Ernst, Matthias

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High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production von Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa, Nilsson, Susan K.

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NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease von Tye, Hazel, Yu, Chien-Hsiung, Simms, Lisa A., de Zoete, Marcel R., Kim, Man Lyang, Zakrzewski, Martha, Penington, Jocelyn S., Harapas, Cassandra R., Souza-Fonseca-Guimaraes, Fernando, Wockner, Leesa F., Preaudet, Adele, Mielke, Lisa A., Wilcox, Stephen A., Ogura, Yasunori, Corr, Sinead C., Kanojia, Komal, Kouremenos, Konstantinos A., De Souza, David P., McConville, Malcolm J., Flavell, Richard A., Gerlic, Motti, Kile, Benjamin T., Papenfuss, Anthony T., Putoczki, Tracy L., Radford-Smith, Graham L., Masters, Seth L.

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming von Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E

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Apoptotic Caspases: Multiple or Mistaken Identities? von McArthur, Kate, Kile, Benjamin T.

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Mitochondrial gene expression is required for platelet function and blood clotting von Richman, Tara R., Ermer, Judith A., Baker, Jessica, Siira, Stefan J., Kile, Benjamin T., Linden, Matthew D., Rackham, Oliver, Filipovska, Aleksandra

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ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia von Thirant, Cécile, Ignacimouttou, Cathy, Lopez, Cécile K., Diop, M’Boyba, Le Mouël, Lou, Thiollier, Clarisse, Siret, Aurélie, Dessen, Phillipe, Aid, Zakia, Rivière, Julie, Rameau, Philippe, Lefebvre, Céline, Khaled, Mehdi, Leverger, Guy, Ballerini, Paola, Petit, Arnaud, Raslova, Hana, Carmichael, Catherine L., Kile, Benjamin T., Soler, Eric, Crispino, John D., Wichmann, Christian, Pflumio, Françoise, Schwaller, Jürg, Vainchenker, William, Lobry, Camille, Droin, Nathalie, Bernard, Olivier A., Malinge, Sébastien, Mercher, Thomas

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Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy von Ngo, Steven, Oxley, Ethan P., Ghisi, Margherita, Garwood, Maximilian M., McKenzie, Mark D., Mitchell, Helen L., Kanellakis, Peter, Susanto, Olivia, Hickey, Michael J., Perkins, Andrew C., Kile, Benjamin T., Dickins, Ross A.

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Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses von Pépin, Geneviève, De Nardo, Dominic, Rootes, Christina L, Ullah, Tomalika R, Al-Asmari, Sumaiah S, Balka, Katherine R, Li, Hong-Mei, Quinn, Kylie M, Moghaddas, Fiona, Chappaz, Stephane, Kile, Benjamin T, Morand, Eric F, Masters, Seth L, Stewart, Cameron R, Williams, Bryan R G, Gantier, Michael P

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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function von Schoenwaelder, Simone M., Yuan, Yuping, Josefsson, Emma C., White, Michael J., Yao, Yu, Mason, Kylie D., O'Reilly, Lorraine A., Henley, Katya J., Ono, Akiko, Hsiao, Sarah, Willcox, Abbey, Roberts, Andrew W., Huang, David C.S., Salem, Hatem H., Kile, Benjamin T., Jackson, Shaun P.

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Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection von Ullah, Tomalika R., Johansen, Matt D., Balka, Katherine R., Ambrose, Rebecca L., Gearing, Linden J., Roest, James, Vivian, Julian P., Sapkota, Sunil, Jayasekara, W. Samantha N., Wenholz, Daniel S., Aldilla, Vina R., Zeng, Jun, Miemczyk, Stefan, Nguyen, Duc H., Hansbro, Nicole G., Venkatraman, Rajan, Kang, Jung Hee, Pang, Ee Shan, Thomas, Belinda J., Alharbi, Arwaf S., Rezwan, Refaya, O’Keeffe, Meredith, Donald, William A., Ellyard, Julia I., Wong, Wilson, Kumar, Naresh, Kile, Benjamin T., Vinuesa, Carola G., Kelly, Graham E., Laczka, Olivier F., Hansbro, Philip M., De Nardo, Dominic, Gantier, Michael P.

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The role of apoptosis in megakaryocytes and platelets von Kile, Benjamin T.

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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis von Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, Norris, Murray D.

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