Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes von Jiao, Yuhao, Davis, Joanne E., Rautela, Jai, Carrington, Emma M., Ludford-Menting, Mandy J., Goh, Wilford, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Koldej, Rachel, Gray, Daniel, Huang, David, Kile, Ben T., Lew, Andrew M., Ritchie, David S., Huntington, Nicholas D.

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Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model von Brown, Fiona C., Conway, Ashlee J., Cerruti, Loretta, Collinge, Janelle E., McLean, Catriona, Wiley, James S., Kile, Ben T., Jane, Stephen M., Curtis, David J.

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Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury von Karve, Ila P, Zhang, Moses, Habgood, Mark, Frugier, Tony, Brody, Kate M, Sashindranath, Maithili, Ek, C Joakim, Chappaz, Stephane, Kile, Ben T, Wright, David, Wang, Hong, Johnston, Leigh, Daglas, Maria, Ates, Robert C, Medcalf, Robert L, Taylor, Juliet M, Crack, Peter J

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126 von Kim, Man Lyang, Chae, Jae Jin, Stirzaker, Ros A., Ko, Hyun-Ja, Roberts, Andrew W., Kastner, Daniel L., Kile, Ben T., Croker, Ben A., Masters, Seth L.

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126: Inflammasome activation due to polymerized actin triggers an autoinflammatory disease that is dependent on IL-18, not IL-1β von Kim, Man Lyang, Chae, Jae Jin, Stirzaker, Ros A., Ko, Hyun-Ja, Roberts, Andrew W., Kastner, Daniel L., Kile, Ben T., Croker, Ben A., Masters, Seth L.

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Abstract 2613: Histone deacetylase inhibitor induced thrombocytopenia occurs due to inhibition platelet shedding by megakaryocytes, via increased phosporylation of myosin light cha... von Bishton, Mark J., Prince, H Miles, Harrison, Simon J., Martin, Ben P., Emma, Josefsson C., James, Chloe, Henley, Katya J., Kile, Ben T., Johnstone, Ricky W.

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Inflammatory Disease and Abortive Platelet Shedding Caused by a Mutation in a Pivotal Regulator of Actin Dynamics in the redears Mouse von Justice, Monica J., Kile, Ben T., Woodward, Lanette S.

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Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury123 von Karve, Ila P., Zhang, Moses, Habgood, Mark, Frugier, Tony, Brody, Kate M., Sashindranath, Maithili, Ek, C. Joakim, Chappaz, Stephane, Kile, Ben T., Wright, David, Wang, Hong, Johnston, Leigh, Daglas, Maria, Ates, Robert C., Medcalf, Robert L., Taylor, Juliet M., Crack, Peter J.

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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells von Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

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IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome von Murphy, Andrew J., Kraakman, Michael J., Kammoun, Helene L., Dragoljevic, Dragana, Lee, Man K.S., Lawlor, Kate E., Wentworth, John M., Vasanthakumar, Ajithkumar, Gerlic, Motti, Whitehead, Lachlan W., DiRago, Ladina, Cengia, Louise, Lane, Rachael M., Metcalf, Donald, Vince, James E., Harrison, Leonard C., Kallies, Axel, Kile, Benjamin T., Croker, Ben A., Febbraio, Mark A., Masters, Seth L.

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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β von Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A, Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W, Kastner, Daniel L, Lew, Andrew M, Lyras, Dena, Kile, Benjamin T, Croker, Ben A, Masters, Seth L

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Developmental cell programs are co-opted in inflammatory skin disease von Reynolds, Gary, Vegh, Peter, Fletcher, James, Poyner, Elizabeth F. M., Stephenson, Emily, Goh, Issac, Botting, Rachel A., Huang, Ni, Olabi, Bayanne, Dubois, Anna, Dixon, David, Green, Kile, Maunder, Daniel, Engelbert, Justin, Efremova, Mirjana, Polanski, Krzysztof, Jardine, Laura, Jones, Claire, Ness, Thomas, Horsfall, Dave, McGrath, Jim, Carey, Christopher, Popescu, Dorin-Mirel, Webb, Simone, Wang, Xiao-Nong, Sayer, Ben, Park, Jong-Eun, Negri, Victor A., Belokhvostova, Daria, Lynch, Magnus D., McDonald, David, Filby, Andrew, Hagai, Tzachi, Meyer, Kerstin B., Husain, Akhtar, Coxhead, Jonathan, Vento-Tormo, Roser, Behjati, Sam, Lisgo, Steven, Villani, Alexandra-Chloe, Bacardit, Jaume, Jones, Philip H., O'Toole, Edel A., Ogg, Graham S., Rajan, Neil, Reynolds, Nick J., Teichmann, Sarah A., Watt, Fiona M., Haniffa, Muzlifah

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Decoding human fetal liver haematopoiesis von Popescu, Dorin-Mirel, Botting, Rachel A., Stephenson, Emily, Green, Kile, Webb, Simone, Jardine, Laura, Calderbank, Emily F., Polanski, Krzysztof, Goh, Issac, Efremova, Mirjana, Acres, Meghan, Maunder, Daniel, Vegh, Peter, Gitton, Yorick, Park, Jong-Eun, Vento-Tormo, Roser, Miao, Zhichao, Dixon, David, Rowell, Rachel, McDonald, David, Fletcher, James, Poyner, Elizabeth, Reynolds, Gary, Mather, Michael, Moldovan, Corina, Mamanova, Lira, Greig, Frankie, Young, Matthew D., Meyer, Kerstin B., Lisgo, Steven, Bacardit, Jaume, Fuller, Andrew, Millar, Ben, Innes, Barbara, Lindsay, Susan, Stubbington, Michael J. T., Kowalczyk, Monika S., Li, Bo, Ashenberg, Orr, Tabaka, Marcin, Dionne, Danielle, Tickle, Timothy L., Slyper, Michal, Rozenblatt-Rosen, Orit, Filby, Andrew, Carey, Peter, Villani, Alexandra-Chloé, Roy, Anindita, Regev, Aviv, Chédotal, Alain, Roberts, Irene, Göttgens, Berthold, Behjati, Sam, Laurenti, Elisa, Teichmann, Sarah A., Haniffa, Muzlifah

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NLRP1a Expression in Srebp-1a-Deficient Mice von Gerlic, Motti, Croker, Ben A., Cengia, Louise H., Moayeri, Mahtab, Kile, Benjamin T., Masters, Seth L.

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Abstract 1694: Computational analysis of multiplexed immunohistochemistry for understanding immune profiles in clinical biopsies von Krueger, Joseph S., Hirsch, Brooke, Bell, Mandy, Ryall, Karen, Landis, Nick, Young, G David, McFadden, Kile, Landis, Ben

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Thrombocytopenia and Kidney Disease in Mice with a Mutation in the C1galt1 Gene von Alexander, Warren S., Viney, Elizabeth M., Zhang, Jian-Guo, Metcalf, Donald, Kauppi, Maria, Hyland, Craig D., Carpinelli, Marina R., Stevenson, William, Croker, Ben A., Hilton, Adrienne A., Ellis, Sarah, Selan, Carly, Nandurkar, Harshal H., Goodnow, Christopher C., Kile, Benjamin T., Nicola, Nicos A., Roberts, Andrew W., Hilton, Douglas J.

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Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome... von Rajput, Sandeep K., Logsdon, Deirdre M., Kile, Becca, Engelhorn, Heidi J., Goheen, Ben, Khan, Shaihla, Swain, Jason, McCormick, Sue, Schoolcraft, William B., Yuan, Ye, Krisher, Rebecca L.

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Early Molecular Stratification of High-risk Primary Biliary Cholangitis von Hardie, Claire, Green, Kile, Jopson, Laura, Millar, Ben, Innes, Barbara, Pagan, Sarah, Tiniakos, Dina, Dyson, Jessica, Haniffa, Muzlifah, Bigley, Venetia, Jones, David E, Brain, John, Walker, Lucy J

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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β von Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A., Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W., Kastner, Daniel L., Lew, Andrew M., Lyras, Dena, Kile, Benjamin T., Croker, Ben A., Masters, Seth L.

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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β von Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A, Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W, Kastner, Daniel L, Lew, Andrew M, Lyras, Dena, Kile, Benjamin T, Croker, Ben A, Masters, Seth L

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