Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) von Dall'Acqua, William F., Kiener, Peter A., Wu, Herren

Volltext

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway von Higgs, Brandon W, Liu, Zheng, White, Barbara, Zhu, Wei, White, Wendy I, Morehouse, Chris, Brohawn, Philip, Kiener, Peter A, Richman, Laura, Fiorentino, David, Greenberg, Steven A, Jallal, Bahija, Yao, Yihong

Volltext

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function von Kolbeck, Roland, PhD, Kozhich, Alexander, PhD, Koike, Masamichi, PhD, Peng, Li, PhD, Andersson, Cecilia K., PhD, Damschroder, Melissa M., BA, Reed, Jennifer L., PhD, Woods, Robert, MS, Dall'Acqua, William W., PhD, Stephens, Geoffrey L., PhD, Erjefalt, Jonas S., PhD, Bjermer, Leif, MD, Humbles, Alison A., PhD, Gossage, David, MD, Wu, Herren, PhD, Kiener, Peter A., PhD, Spitalny, George L., PhD, Mackay, Charles R., PhD, Molfino, Nestor A., MD, Coyle, Anthony J., PhD

Volltext

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE von Coyle, Anthony J, Tian, Jane, Avalos, Ana Maria, Mao, Su-Yau, Chen, Bo, Senthil, Kannaki, Wu, Herren, Parroche, Peggy, Drabic, Stacey, Golenbock, Douglas, Sirois, Cherilyn, Hua, Jing, An, Ling Ling, Audoly, Laurent, La Rosa, Greg, Bierhaus, Angelika, Naworth, Peter, Marshak-Rothstein, Ann, Crow, Mary K, Fitzgerald, Katherine A, Latz, Eicke, Kiener, Peter A

Volltext

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma von Busse, William W., MD, Katial, Rohit, MD, Gossage, David, MD, MBA, Sari, Suha, PhD, Wang, Bing, PhD, Kolbeck, Roland, PhD, Coyle, Anthony J., PhD, Koike, Masamichi, PhD, Spitalny, George L., PhD, Kiener, Peter A., PhD, Geba, Gregory P., MD, MPH, Molfino, Nestor A., MD

Volltext

Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract von Wu, Herren, Pfarr, David S., Johnson, Syd, Brewah, Yambasu A., Woods, Robert M., Patel, Nita K., White, Wendy I., Young, James F., Kiener, Peter A.

Volltext

CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies von Quayle, Steven N., Girgis, Natasha, Thapa, Dharma R., Merazga, Zohra, Kemp, Melissa M., Histed, Alex, Zhao, Fan, Moreta, Miguel, Ruthardt, Paige, Hulot, Sandrine, Nelson, Alyssa, Kraemer, Lauren D., Beal, Dominic R., Witt, Luke, Ryabin, Jessica, Soriano, Jonathan, Haydock, Mark, Spaulding, Emily, Ross, John F., Kiener, Peter A., Almo, Steven, Chaparro, Rodolfo, Seidel, Ronald, Suri, Anish, Cemerski, Saso, Pienta, Kenneth J., Simcox, Mary Ellen

Volltext

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways von KEARLEY, Jennifer, ERJEFALT, Jonas S, KIENER, Peter A, KOLBECK, Roland, LLOYD, Clare M, COYLE, Anthony J, HUMBLES, Alison A, ANDERSSON, Cecilia, BENJAMIN, Ebony, JONES, Carla P, ROBICHAUD, Annette, PEGORIER, Sophie, BREWAH, Yambasu, BURWELL, Timothy J, BJERMER, Leif

Volltext

Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells von Seidel, Ronald D., Merazga, Zohra, Thapa, Dharma Raj, Soriano, Jonathan, Spaulding, Emily, Vakkasoglu, Ahmet S., Ruthardt, Paige, Bautista, Wynona, Quayle, Steven N., Kiener, Peter A., Low, Simon, Ross, John F., Cemerski, Saso, Suri, Anish, Almo, Steven C., Chaparro, Rodolfo J.

Volltext

YKL-40 Is Elevated in Patients with Chronic Obstructive Pulmonary Disease and Activates Alveolar Macrophages von Letuve, Severine, Kozhich, Alexander, Arouche, Nassim, Grandsaigne, Martine, Reed, Jennifer, Dombret, Marie-Christine, Kiener, Peter A, Aubier, Michel, Coyle, Anthony J, Pretolani, Marina

Volltext

The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators von Dimasi, Nazzareno, Gao, Changshou, Fleming, Ryan, Woods, Robert M., Yao, Xiao-Tao, Shirinian, Lena, Kiener, Peter A., Wu, Herren

Volltext

Type I interferon: potential therapeutic target for psoriasis? von Yao, Yihong, Richman, Laura, Morehouse, Chris, de los Reyes, Melissa, Higgs, Brandon W, Boutrin, Anmarie, White, Barbara, Coyle, Anthony, Krueger, James, Kiener, Peter A, Jallal, Bahija

Volltext

Ultra-potent Antibodies Against Respiratory Syncytial Virus: Effects of Binding Kinetics and Binding Valence on Viral Neutralization von Wu, Herren, Pfarr, David S., Tang, Ying, An, Ling-Ling, Patel, Nita K., Watkins, Jeffry D., Huse, William D., Kiener, Peter A., Young, James F.

Volltext

Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis von Reed, Jennifer L., Brewah, Yambasu A., Delaney, Tracy, Welliver, Timothy, Burwell, Timothy, Benjamin, Ebony, Kuta, Ellen, Kozhich, Alexander, McKinney, LuAnn, Suzich, JoAnn, Kiener, Peter A., Avendano, Luis, Velozo, Luis, Humbles, Alison, Welliver, Robert C., Coyle, Anthony J.

Volltext

Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences von Acqua, William F. Dall, Woods, Robert M, Ward, E. Sally, Palaszynski, Susan R, Patel, Nita K, Brewah, Yambasu A, Wu, Herren, Kiener, Peter A, Langermann, Solomon

Volltext

EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma von THAKER, Premal H, DEAVERS, Michael, CELESTINO, Joseph, THORNTON, Angela, FLETCHER, Mavis S, LANDEN, Charles N, KINCH, Michael S, KIENER, Peter A, SOOD, Anil K

Volltext

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo von Jackson, Dowdy, Gooya, John, Mao, Shenlan, Kinneer, Krista, Xu, Linda, Camara, Margarita, Fazenbaker, Christine, Fleming, Ryan, Swamynathan, Sudha, Meyer, Damon, Senter, Peter D, Gao, Changshou, Wu, Herren, Kinch, Michael, Coats, Steven, Kiener, Peter A, Tice, David A

Volltext

Cell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral Interference of RIG-I Ligand Recognition by HMPV-B1 P... von Goutagny, Nadege, Jiang, Zhaozhao, Tian, Jane, Parroche, Peggy, Schickli, Jeanne, Monks, Brian G, Ulbrandt, Nancy, Ji, Hong, Kiener, Peter A, Coyle, Anthony J, Fitzgerald, Katherine A

Volltext

Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages von Park, David R, Thomsen, Anni R, Frevert, Charles W, Pham, Uyenvy, Skerrett, Shawn J, Kiener, Peter A, Liles, W. Conrad

Volltext

Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct von HAMMOND, Scott A, LUTTERBUESE, Ralf, KIENER, Peter A, ROFF, Shannon, LUTTERBUESE, Petra, SCHLERETH, Bernd, BRUCKHEIMER, Elizabeth, KINCH, Michael S, COATS, Steve, BAEUERLE, Patrick A, KUFER, Peter

Volltext