Streamlining multi-omic and artificial intelligence analysis through interrogative biology and baicis for translational precision medicine applications in clinical oncology von Rodrigues, L., Kiebish, M.A., Miller, G., Zhang, L., Vemulapalli, V., Vishnudas, V.K., Sarangarajan, R., Narain, N.R., Akmaev, V.R.

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P1426: WU‐NK‐101, AN ALLOGENEIC MEMORY NK CELL, FOR THE TREATMENT OF RELAPSE OR REFRACTORY (R/R) ACUTE MYELOID LEUKEMIA (AML) von Muth, J. J., Mathyer, M. E., Cruz, B., DuFour, C., Leedom, T., Hamil, A. S., Pouyanfard, S., Berrien‐Elliot, M., Luukkonen, L., Tran, M., Tumala, B., Pomper, N., Arthur, L., Foster, M., Gorrochategui, J., Comune Pennacchi, P., Primo, D., Ballesteros, J., Tolstikov, V., Kiebish, M. A., Shah, P., Vadakekolathu, J., Rutella, S., Fehniger, T. A., Sullivan, R., Kabakibi, A., Cooper, M. L., Davidson‐Moncada, J.

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1485P Identification of novel protein biomarkers for FOLFIRINOX-based chemotherapy response in advanced pancreatic adenocarcinoma using patient omics and Bayesian AI von Moser, A.J., Kiebish, M., Sarangarajan, R., Chand, N.M., Miller, G., Rodrigues, L., Shah, P., Searfoss, R., Ofori-Mensa, K., Tolstikov, V., Greenwood, B., Bussberg, V., Grund, E.M., DeCicco, C., Granger, E., Narain, N.R.

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11P WU-NK-101: An enhanced NK cell therapy optimized for function in the tumor microenvironment (TME) von Rutella, S., Muth, J., Vadakekulathu, J., Mathyer, M.E., Tumala, B.R., Foster, M., Baughman, J., Comune Pennacchi, P., Tolstikov, V., Carter, A., Primo, D., Gorrochategui, J., Magee, K., Shah, P., Kiebish, M., Ballesteros, J., Cooper, M.L., Berrien-Elliott, M., Fehniger, T.A., Davidson-Moncada, J.K.

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498P - Proteomic profiling identifies molecular basis of adverse event to BPM31510 exposure: Rationale for comprehensive molecular pharmacodynamics (PD) in phase I clinical trial d... von Subbiah, V., Granger, E., Kiebish, M., Zinner, R., Hong, D.S., Miller, G., Zhang, L., Vemulapalli, V., Rodrigues, L., Narain, N., Sarangarajan, R.

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498PProteomic profiling identifies molecular basis of adverse event to BPM31510 exposure: Rationale for comprehensive molecular pharmacodynamics (PD) in phase I clinical trial desi... von Subbiah, V, Granger, E, Kiebish, M, Zinner, R, Hong, D S, Miller, G, Zhang, L, Vemulapalli, V, Rodrigues, L, Narain, N, Sarangarajan, R

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Proteomic profiling identifies molecular basis of adverse event to BPM31510 exposure: Rationale for comprehensive molecular pharmacodynamics (PD) in phase I clinical trial design von Subbiah, V., Granger, E., Kiebish, M., Zinner, R., Hong, D.S., Miller, G., Zhang, L., Vemulapalli, V., Rodrigues, L., Narain, N., Sarangarajan, R.

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410 Alterations of the Plasma Lipidome in Response to Severe Burn Injury von Baer, L A, Kiebish, M A, Wade, C E, Stanford, K I

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1886PStreamlining multi-omic and artificial intelligence analysis through interrogative biology and baicis for translational precision medicine applications in clinical oncology von Rodrigues, L, Kiebish, M A, Miller, G, Zhang, L, Vemulapalli, V, Vishnudas, V K, Sarangarajan, R, Narain, N R, Akmaev, V R

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Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease von Girdhar, Khyati, Dogru, Yusuf Dogus, Huang, Qian, Yang, Yi, Tolstikov, Vladimir, Raisingani, Amol, Chrudinova, Martina, Oh, Jaewon, Kelley, Kristina, Ludvigsson, Jonas F, Kiebish, Michael A, Palm, Noah W, Ludvigsson, Johnny, Altindis, Emrah

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Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors von Kiebish, Michael A, Seyfried, Thomas N

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The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue von Lynes, Matthew D, Leiria, Luiz O, Lundh, Morten, Bartelt, Alexander, Shamsi, Farnaz, Huang, Tian Lian, Takahashi, Hirokazu, Hirshman, Michael F, Schlein, Christian, Lee, Alexandra, Baer, Lisa A, May, Francis J, Gao, Fei, Narain, Niven R, Chen, Emily Y, Kiebish, Michael A, Cypess, Aaron M, Blüher, Matthias, Goodyear, Laurie J, Hotamisligil, Gökhan S, Stanford, Kristin I, Tseng, Yu-Hua

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12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake von Stanford, Kristin I., Lynes, Matthew D., Takahashi, Hirokazu, Baer, Lisa A., Arts, Peter J., May, Francis J., Lehnig, Adam C., Middelbeek, Roeland J.W., Richard, Jeffrey J., So, Kawai, Chen, Emily Y., Gao, Fei, Narain, Niven R., Distefano, Giovanna, Shettigar, Vikram K., Hirshman, Michael F., Ziolo, Mark T., Kiebish, Michael A., Tseng, Yu-Hua, Coen, Paul M., Goodyear, Laurie J.

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Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism von Lynes, Matthew D., Shamsi, Farnaz, Sustarsic, Elahu Gosney, Leiria, Luiz O., Wang, Chih-Hao, Su, Sheng-Chiang, Huang, Tian Lian, Gao, Fei, Narain, Niven R., Chen, Emily Y., Cypess, Aaron M., Schulz, Tim J., Gerhart-Hines, Zachary, Kiebish, Michael A., Tseng, Yu-Hua

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A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function von Pinckard, Kelsey M., Shettigar, Vikram K., Wright, Katherine R., Abay, Eaman, Baer, Lisa A., Vidal, Pablo, Dewal, Revati S., Das, Devleena, Duarte-Sanmiguel, Silvia, Hernández-Saavedra, Diego, Arts, Peter J., Lehnig, Adam C., Bussberg, Valerie, Narain, Niven R., Kiebish, Michael A., Yi, Fanchao, Sparks, Lauren M., Goodpaster, Bret H., Smith, Steven R., Pratley, Richard E., Lewandowski, E. Douglas, Raman, Subha V., Wold, Loren E., Gallego-Perez, Daniel, Coen, Paul M., Ziolo, Mark T., Stanford, Kristin I.

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Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore von Moon, Sung Ho, Liu, Xinping, Cedars, Ari M., Yang, Kui, Kiebish, Michael A., Joseph, Susan M., Kelley, John, Jenkins, Christopher M., Gross, Richard W.

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Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice von Tsuji, Tadataka, Bussberg, Valerie, MacDonald, Allison M, Narain, Niven R, Kiebish, Michael A, Tseng, Yu-Hua

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Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma von Mukherjee, Purna, Augur, Zachary M., Li, Mingyi, Hill, Collin, Greenwood, Bennett, Domin, Marek A., Kondakci, Gramoz, Narain, Niven R., Kiebish, Michael A., Bronson, Roderick T., Arismendi-Morillo, Gabriel, Chinopoulos, Christos, Seyfried, Thomas N.

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Impact of hemolysis on multi-OMIC pancreatic biomarker discovery to derisk biomarker development in precision medicine studies von Searfoss, Richard, Shah, Punit, Ofori-Mensa, Kennedy, Bussberg, Valerie, Tolstikov, Vladimir, Greenwood, Bennett, Li, Hongyan, Richardson, Kris, Miller, Gregory M., DeCicco, Corinne, Granger, Elder, Rodrigues, Leonardo O., Grund, Eric M., Moser, A. James, Sarangarajan, Rangaprasad, Narain, Niven R., Kiebish, Michael A.

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Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults von Standley, Robert A, Distefano, Giovanna, Trevino, Michelle B, Chen, Emily, Narain, Niven R, Greenwood, Bennett, Kondakci, Gramoz, Tolstikov, Vladimir V, Kiebish, Michael A, Yu, Gongxin, Qi, Feng, Kelly, Daniel P, Vega, Rick B, Coen, Paul M, Goodpaster, Bret H

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