Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities von Zhang, Donglu, Hop, Cornelis E C A, Patilea-Vrana, Gabriela, Gampa, Gautham, Seneviratne, Herana Kamal, Unadkat, Jashvant D, Kenny, Jane R, Nagapudi, Karthik, Di, Li, Zhou, Lian, Zak, Mark, Wright, Matthew R, Bumpus, Namandjé N, Zang, Richard, Liu, Xingrong, Lai, Yurong, Khojasteh, S Cyrus

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Biosynthetic Strategies for Macrocyclic Peptides von Wang, Wei, Khojasteh, S Cyrus, Su, Dian

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Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1- a ]isoindole and Species Differences i... von Wang, Shuai, Ma, Shuguang, Chen, Eugene, Wang, Jing, Le, Hoa, Hanlon, Steven Paul, Binder, Martin, Lee, Wendy, Khojasteh, S Cyrus, Salphati, Laurent

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human von Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates von Zhang, Donglu, Yu, Shang-Fan, Khojasteh, S Cyrus, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Kozak, Katherine R, Xu, Keyang, Polson, Andrew G, Dragovich, Peter S, Hop, Cornelis E C A

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Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine von Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P., Fan, Peter W., Murray, Bernard P., Takahashi, Ryan H., Khojasteh, S. Cyrus, Smith, Bill J., Thummel, Kenneth E., Prasad, Bhagwat

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Drug–Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug–Drug Interactio... von Kenny, Jane R., Mukadam, Sophie, Zhang, Chenghong, Tay, Suzanne, Collins, Carol, Galetin, Aleksandra, Khojasteh, S. Cyrus

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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues von Zhang, Donglu, Dragovich, Peter S., Yu, Shang-Fan, Ma, Yong, Pillow, Thomas H., Sadowsky, Jack D., Su, Dian, Wang, Wei, Polson, Andrew, Khojasteh, S. Cyrus, Hop, Cornelis E.C.A.

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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates von Zhang, Donglu, Fourie-O’Donohue, Aimee, Dragovich, Peter S., Pillow, Thomas H., Sadowsky, Jack D., Kozak, Katherine R., Cass, Robert T., Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis E.C.A., Khojasteh, S. Cyrus

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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates von Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S

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A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834 von Sodhi, Jasleen K, Wong, Susan, Kirkpatrick, Donald S, Liu, Lichuan, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Barr, John T, Jones, Jeffrey P, Halladay, Jason S

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An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepato... von Halladay, Jason S., Wong, Susan, Khojasteh, S. Cyrus, Grepper, Susan

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors von Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Christopher A., Kenny, Jane R., Cyrus Khojasteh, S., Le, Hoa, Lee, Leslie, Lyssikatos, Joseph P., Magnuson, Steve, Pulk, Rebecca, Tsui, Vickie, Ultsch, Mark, Xiao, Yisong, Zhu, Bing-yan, Sampath, Deepak

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Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton’s Tyrosine Kinase Inhibitor von Liu, Lichuan, Halladay, Jason S., Shin, Young, Wong, Susan, Coraggio, Melis, La, Hank, Baumgardner, Matthew, Le, Hoa, Gopaul, Sashi, Boggs, Jason, Kuebler, Peter, Davis, John C., Liao, X. Charlene, Lubach, Joseph W., Deese, Alan, Sowell, C. Gregory, Currie, Kevin S., Young, Wendy B., Khojasteh, S. Cyrus, Hop, Cornelis E.C.A., Wong, Harvey

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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs von Zhang, Donglu, Ma, Bin, Dragovich, Peter S., Ma, Li, Chen, Shu, Chen, Eugene C., Ye, Xiaofen, Liu, Joyce, Pizzano, Jennifer, Bortolon, Elizabeth, Chan, Emily, Zhang, Xing, Chen, Yi-Chen, Levy, Elizabeth S., Yauch, Robert L., Khojasteh, S. Cyrus, Hop, Cornelis E. C. A.

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Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats von Khojasteh, S. Cyrus, Oishi, Shimako, Nelson, Sidney D

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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8) von Ma, Yong, Fu, Yue, Khojasteh, S Cyrus, Dalvie, Deepak, Zhang, Donglu

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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species von Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

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Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings von Dalvie, Deepak K, Kalgutkar, Amit S, Khojasteh-Bakht, S. Cyrus, Obach, R. Scott, O'Donnell, John P

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance von Schadt, Simone, Bister, Bojan, Chowdhury, Swapan K., Funk, Christoph, Hop, Cornelis E.C.A., Humphreys, W. Griffith, Igarashi, Fumihiko, James, Alexander D., Kagan, Mark, Khojasteh, S. Cyrus, Nedderman, Angus N.R., Prakash, Chandra, Runge, Frank, Scheible, Holger, Spracklin, Douglas K., Swart, Piet, Tse, Susanna, Yuan, Josh, Obach, R. Scott

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