Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress von Qu, Jia-Hua, Chakir, Khalid, Tarasov, Kirill V, Riordon, Daniel R, Perino, Maria Grazia, Silvester, Allwin Jennifa, Lakatta, Edward G

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Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle von Ramirez-Correa, Genaro A, Ma, Junfeng, Slawson, Chad, Zeidan, Quira, Lugo-Fagundo, Nahyr S, Xu, Mingguo, Shen, Xiaoxu, Gao, Wei Dong, Caceres, Viviane, Chakir, Khalid, DeVine, Lauren, Cole, Robert N, Marchionni, Luigi, Paolocci, Nazareno, Hart, Gerald W, Murphy, Anne M

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Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy von Cho, Gun-Sik, Lee, Dong I., Tampakakis, Emmanouil, Murphy, Sean, Andersen, Peter, Uosaki, Hideki, Chelko, Stephen, Chakir, Khalid, Hong, Ingie, Seo, Kinya, Chen, Huei-Sheng Vincent, Chen, Xiongwen, Basso, Cristina, Houser, Steven R., Tomaselli, Gordon F., O’Rourke, Brian, Judge, Daniel P., Kass, David A., Kwon, Chulan

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Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy von AIBA, Takeshi, HESKETH, Geoffrey G, KASS, David A, TOMASELLI, Gordon F, BARTH, Andreas S, TING LIU, DAYA, Samantapudi, CHAKIR, Khalid, LEA DIMAANO, Veronica, ABRAHAM, Theodore P, O'ROURKE, Brian, AKAR, Fadi G

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A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8 von Tarasov, Kirill V, Chakir, Khalid, Riordon, Daniel R, Lyashkov, Alexey E, Ahmet, Ismayil, Perino, Maria Grazia, Silvester, Allwin Jennifa, Zhang, Jing, Wang, Mingyi, Lukyanenko, Yevgeniya O, Qu, Jia-Hua, Barrera, Miguel Calvo-Rubio, Juhaszova, Magdalena, Tarasova, Yelena S, Ziman, Bruce, Telljohann, Richard, Kumar, Vikas, Ranek, Mark, Lammons, John, Bychkov, Rostislav, de Cabo, Rafael, Jun, Seungho, Keceli, Gizem, Gupta, Ashish, Yang, Dongmei, Aon, Miguel A, Adamo, Luigi, Morrell, Christopher H, Otu, Walter, Carroll, Cameron, Chambers, Shane, Paolocci, Nazareno, Huynh, Thanh, Pacak, Karel, Weiss, Robert, Field, Loren, Sollott, Steven J, Lakatta, Edward G

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Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and Rhythm von Moen, Jack M, Matt, Michael G, Ramirez, Christopher, Tarasov, Kirill V, Chakir, Khalid, Tarasova, Yelena S, Lukyanenko, Yevgeniya, Tsutsui, Kenta, Monfredi, Oliver, Morrell, Christopher H, Tagirova, Syevda, Yaniv, Yael, Huynh, Thanh, Pacak, Karel, Ahmet, Ismayil, Lakatta, Edward G

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Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome von Qu, Jia-Hua, Tarasov, Kirill V, Chakir, Khalid, Tarasova, Yelena S, Riordon, Daniel R, Lakatta, Edward G

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Gi-Biased β2AR Signaling Links GRK2 Upregulation to Heart Failure von Zhu, Weizhong, Petrashevskaya, Natalia, Ren, Shuxun, Zhao, Aizhi, Chakir, Khalid, Gao, Erhe, Chuprun, J Kurt, Wang, Yibin, Talan, Mark, Dorn, Gerald W, Lakatta, Edward G, Koch, Walter J, Feldman, Arthur M, Xiao, Rui-Ping

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Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization von CHAKIR, Khalid, DAYA, Samantapudi K, TUNIN, Richard S, HELM, Robert H, BYRNE, Melissa J, DIMAANO, Veronica L, LARDO, Albert C, ABRAHAM, Theodore P, TOMASELLI, Gordon F, KASS, David A

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Cardiac Resynchronization Therapy Corrects Dyssynchrony-Induced Regional Gene Expression Changes on a Genomic Level von Barth, Andreas S, Aiba, Takeshi, Halperin, Victoria, DiSilvestre, Deborah, Chakir, Khalid, Colantuoni, Carlo, Tunin, Richard S, Dimaano, Victoria Lea, Yu, Wayne, Abraham, Theodore P, Kass, David A, Tomaselli, Gordon F

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Modulation of Mitochondrial Proteome and Improved Mitochondrial Function by Biventricular Pacing of Dyssynchronous Failing Hearts von Agnetti, Giulio, Kaludercic, Nina, Kane, Lesley A, Elliott, Steven T, Guo, Yurong, Chakir, Khalid, Samantapudi, Daya, Paolocci, Nazareno, Tomaselli, Gordon F, Kass, David A, Van Eyk, Jennifer E

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Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine von Hiemstra, Jessica A., Lee, Dong I., Chakir, Khalid, Gutiérrez‐Aguilar, Manuel, Marshall, Kurt D., Zgoda, Pamela J., Cruz Rivera, Noelany, Dozier, Daniel G., Ferguson, Brian S., Heublein, Denise M., Burnett, John C., Scherf, Carolin, Ivey, Jan R., Minervini, Gianmaria, McDonald, Kerry S., Baines, Christopher P., Krenz, Maike, Domeier, Timothy L., Emter, Craig A.

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Comparative Molecular Field Analysis of the Binding of the Stereoisomers of Fenoterol and Fenoterol Derivatives to the β2 Adrenergic Receptor von Jozwiak, Krzysztof, Khalid, Chakir, Tanga, Mary J, Berzetei-Gurske, Ilona, Jimenez, Lucita, Kozocas, Joseph A, Woo, Anthony, Zhu, Weizhong, Xiao, Rui-Ping, Abernethy, Darrell R, Wainer, Irving W

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Cardiac Resynchronization Therapy Improves Altered Na Channel Gating in Canine Model of Dyssynchronous Heart Failure von Aiba, Takeshi, Barth, Andreas S, Hesketh, Geoffrey G, Hashambhoy, Yasmin L, Chakir, Khalid, Tunin, Richard S, Greenstein, Joseph L, Winslow, Raimond L, Kass, David A, Tomaselli, Gordon F

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Abstract P307: An Exquisite Cardiac Performance And Protection Package Emerges In Mouse With Cardiac-specific Overexpression Of Adenylyl Cyclase Type 8 von Qu, Jia-Hua, Tarasov, Kirill, Chakir, Khalid, Lakatta, Edward G

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Cardiac-specific overexpression of adenylyl cyclase 8 reprograms the mouse sinoatrial node transcriptome von Qu, Jia-Hua, Tarasov, Kirill V., Chakir, Khalid, Lakatta, Edward G.

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Hypertrophy Signaling Pathways in Experimental Chronic Aortic Regurgitation von Olsen, Niels Thue, Dimaano, Veronica L., Fritz-Hansen, Thomas, Sogaard, Peter, Chakir, Khalid, Eskesen, Kristian, Steenbergen, Charles, Kass, David A., Abraham, Theodore P.

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Phosphatidylinositol 3-Kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes von Leblais, Veronique, Jo, Su-Hyun, Chakir, Khalid, Maltsev, Victor, Zheng, Ming, Crow, Michael T, Wang, Wang, Lakatta, Edward G, Xiao, Rui-Ping

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Reduced Basal Heart Rate Variability in a Calcineurin Aβ Deficient Mouse von Bonin, Janet Elise, Rutishauser, Carolyn, Chakir, Khalid, Lakatta, Edward

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Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study von Melman, Yonathan F, Shah, Ravi, Danielson, Kirsty, Xiao, Junjie, Simonson, Bridget, Barth, Andreas, Chakir, Khalid, Lewis, Gregory D, Lavender, Zachary, Truong, Quynh A, Kleber, Andre, Das, Ranendra, Rosenzweig, Anthony, Wang, Yaoyu, Kass, David A, Singh, Jagmeet P, Das, Saumya

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