A natural genetic variant of granzyme B confers lethality to a common viral infection von Andoniou, Christopher E, Sutton, Vivien R, Wikstrom, Matthew E, Fleming, Peter, Thia, Kevin Y T, Matthews, Antony Y, Kaiserman, Dion, Schuster, Iona S, Coudert, Jerome D, Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I, Trapani, Joseph A, Degli-Esposti, Mariapia A

Volltext

Perforin Is a Major Contributor to NK Cell Control of Tumor Metastasis von Smyth, Mark J, Thia, Kevin Y. T, Cretney, Erika, Kelly, Janice M, Snook, Marie B, Forbes, Catherine A, Scalzo, Anthony A

Volltext

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma von Flinsenberg, Thijs W H, Tromedjo, Charnelle C, Hu, Nan, Liu, Ye, Guo, Yin, Thia, Kevin Y T, Noori, Tahereh, Song, Xiaomin, Aw Yeang, Han X, Tantalo, Daniela G, Handunnetti, Sasanka, Seymour, John F, Roberts, Andrew W, Ritchie, David, Koldej, Rachel, Neeson, Paul J, Wang, Lai, Trapani, Joseph A, Tam, Constantine S, Voskoboinik, Ilia

Volltext

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis von Jang, Helena S., Flinsenberg, Thijs W. H., Lacaze, Paul, Thia, Kevin Y. T., Noori, Tahereh, Fernando, Suran L., Kerridge, Ian, Riaz, Moeen, McNeil, John J., Blombery, Piers A., Trapani, Joseph A., Voskoboinik, Ilia

Volltext

Recovery of natural killer cell cytotoxicity in a A91V perforinhomozygous patient following severe haemophagocytic lymphohistiocytosis von Jang, Helena S., Flinsenberg, Thijs W. H., Lacaze, Paul, Thia, Kevin Y. T., Noori, Tahereh, Fernando, Suran L., Kerridge, Ian, Riaz, Moeen, McNeil, John J., Blombery, Piers A., Trapani, Joseph A., Voskoboinik, Ilia

Volltext

Differential tumor surveillance by natural killer (NK) and NKT cells von Smyth, M J, Thia, K Y, Street, S E, Cretney, E, Trapani, J A, Taniguchi, M, Kawano, T, Pelikan, S B, Crowe, N Y, Godfrey, D I

Volltext

Human perforin mutations and susceptibility to multiple primary cancers von Trapani, Joseph A, Thia, Kevin Y T, Andrews, Miles, Davis, Ian D, Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G, Phillips, Wayne A, Voskoboinik, Ilia, Cebon, Jonathan S

Volltext

A Clathrin/Dynamin- and Mannose-6-Phosphate Receptor-Independent Pathway for Granzyme B-Induced Cell Death von Trapani, Joseph A., Sutton, Vivien R., Kevin Y. T. Thia, Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A.

Volltext

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains von Thia, Kevin Y. T., Trapani, Joseph A.

Volltext

A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection: e1004526 von Andoniou, Christopher E, Sutton, Vivien R, Wikstrom, Matthew E, Fleming, Peter, Thia, Kevin YT, Matthews, Antony Y, Kaiserman, Dion, Schuster, Iona S, Coudert, Jerome D, Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I, Trapani, Joseph A, Degli-Esposti, Mariapia A

Volltext

HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS von Smyth, Mark J., Browne, Kylie A., Thia, Kevin Y. T., Apostolidis, Vicki A., Kershaw, Michael H., Trapani, Joseph A.

Volltext

Cloning and expression of the recombinant mouse natural killer cell granzymeMet-ase-1 von Kelly, Janice M., O'Connor, Michael D., Hulett, Mark D., Thia, Kevin Y. T., Smyth, Mark J.

Volltext

The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10 von Thia, K Y, Jenkins, N A, Gilbert, D J, Copeland, N G, Smyth, M J

Volltext

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma von Smyth, M J, Thia, K Y, Street, S E, MacGregor, D, Godfrey, D I, Trapani, J A

Volltext

Vascular Gene Expression in Nonneoplastic and Malignant Brain von Madden, Stephen L., Cook, Brian P., Nacht, Mariana, Weber, William D., Callahan, Michelle R., Jiang, Yide, Dufault, Michael R., Zhang, Xiaoming, Zhang, Wen, Walter-Yohrling, Jennifer, Rouleau, Cecile, Akmaev, Viatcheslav R., Wang, Clarence J., Cao, Xiaohong, St. Martin, Thia B., Roberts, Bruce L., Teicher, Beverly A., Klinger, Katherine W., Stan, Radu-Virgil, Lucey, Brenden, Carson-Walter, Eleanor B., Laterra, John, Walter, Kevin A.

Volltext

Activated mouse B cells lack expression of granzyme B von Hagn, Magdalena, Belz, Gabrielle T, Kallies, Axel, Sutton, Vivien R, Thia, Kevin Y, Tarlinton, David M, Hawkins, Edwin D, Trapani, Joseph A

Volltext

Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity von Sun, Jiuru, Bird, Catherina H., Thia, Kevin Y., Matthews, Antony Y., Trapani, Joseph A., Bird, Phillip I.

Volltext

Expression of Recombinant Human MET-ASE-1: A NK Cell-Specific Granzyme von Smyth, M.J., Oconnor, M.D., Kelly, J.M., Ganesvaran, P., Thia, K.Y.T., Trapani, J.A.

Volltext

Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences von Smyth, M J, Hulett, M D, Thia, K Y, Young, H A, Sayers, T J, Carter, C R, Trapani, J A

Volltext