Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation von Boileau, Ryan M, Chen, Kevin X, Blelloch, Robert

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Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300 von Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Njoroge, F. George, Chen, Kevin X, Shih, Neng-Yang, Piwinski, John J

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Differential Susceptibility to Axonopathy in Necrotic and Non-Necrotic Perinatal White Matter Injury von RIDDLE, Art, MAIRE, Jennifer, XI GONG, CHEN, Kevin X, KROENKE, Christopher D, HOHIMER, A. Roger, BACK, Stephen A

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor von Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George

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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) von Romero, F. Anthony, Murray, Jeremy, Lai, Kwong Wah, Tsui, Vickie, Albrecht, Brian K, An, Le, Beresini, Maureen H, de Leon Boenig, Gladys, Bronner, Sarah M, Chan, Emily W, Chen, Kevin X, Chen, Zhongguo, Choo, Edna F, Clagg, Kyle, Clark, Kevin, Crawford, Terry D, Cyr, Patrick, de Almeida Nagata, Denise, Gascoigne, Karen E, Grogan, Jane L, Hatzivassiliou, Georgia, Huang, Wei, Hunsaker, Thomas L, Kaufman, Susan, Koenig, Stefan G, Li, Ruina, Li, Yingjie, Liang, Xiaorong, Liao, Jiangpeng, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Masui, Colin, Merchant, Mark, Ran, Yingqing, Taylor, Alexander M, Wai, John, Wang, Fei, Wei, Xiaocang, Yu, Dong, Zhu, Bing-Yan, Zhu, Xiaoyu, Magnuson, Steven

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HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib von Fang, Douglas D., Zhang, Bin, Gu, Qingyang, Lira, Maruja, Xu, Qiang, Sun, Hongye, Qian, Maoxiang, Sheng, Weiqi, Ozeck, Mark, Wang, Zhenxiong, Zhang, Cathy, Chen, Xinsheng, Chen, Kevin X., Li, Jian, Chen, Shu-Hui, Christensen, James, Mao, Mao, Chan, Chi-Chung

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An Enantioselective Total Synthesis of (+)-Geissoschizine von Martin, Stephen F, Chen, Kevin X, Eary, C. Todd

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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor von Lal, Shruti, Bhola, Neil E., Sun, Bee-Chun, Chen, Yuping, Huang, Tom, Morton, Vivian, Chen, Kevin X., Xia, Shanghua, Zhang, Haoyu, Parikh, Nehal S., Ye, Qiuping, Veiby, O. Petter, Bellovin, David I., Ji, Yuhua

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Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity von Yu, Wensheng, Coburn, Craig A., Yang, De-Yi, Meinke, Peter T., Wong, Michael, Rosenblum, Stuart B., Chen, Kevin X., Njoroge, George F., Chen, Lei, Dwyer, Michael P., Jiang, Yueheng, Nair, Anilkumar G., Selyutin, Oleg, Tong, Ling, Zeng, Qingbei, Zhong, Bin, Ji, Tao, Hu, Bin, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Liu, Rong, Kong, Rong, Ingravallo, Paul, Asante-Appiah, Ernest, Nomeir, Amin, Fells, James, Kozlowski, Joseph A.

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Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase von Chen, Kevin X, Vibulbhan, Bancha, Yang, Weiying, Sannigrahi, Mousumi, Velazquez, Francisco, Chan, Tin-Yau, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Bennet, Frank, Jiang, Yueheng, Lesburg, Charles A, Duca, Jose, Pinto, Patrick, Gavalas, Stephen, Huang, Yuhua, Wu, Wanli, Selyutin, Oleg, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics von Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Heimark, Larry, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

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I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles von Anilkumar, Gopinadhan N., Lesburg, Charles A., Selyutin, Oleg, Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Chan, Tin-Yau, Pu, Haiyan, Vaccaro, Henry, Wang, Li, Bennett, Frank, Chen, Kevin X., Duca, Jose, Gavalas, Stephen, Huang, Yuhua, Pinto, Patrick, Sannigrahi, Mousumi, Velazquez, Francisco, Venkatraman, Srikanth, Vibulbhan, Bancha, Agrawal, Sony, Butkiewicz, Nancy, Feld, Boris, Ferrari, Eric, He, Zhiqing, Jiang, Chuan-kui, Palermo, Robert E., Mcmonagle, Patricia, Huang, H.-C., Shih, Neng-Yang, Njoroge, George, Kozlowski, Joseph A.

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A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors von Chen, Kevin X, Lesburg, Charles A, Vibulbhan, Bancha, Yang, Weiying, Chan, Tin-Yau, Venkatraman, Srikanth, Velazquez, Francisco, Zeng, Qingbei, Bennett, Frank, Anilkumar, Gopinadhan N, Duca, Jose, Jiang, Yueheng, Pinto, Patrick, Wang, Li, Huang, Yuhua, Selyutin, Oleg, Gavalas, Stephen, Pu, Haiyan, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase von Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

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Second-Generation Highly Potent and Selective Inhibitors of the Hepatitis C Virus NS3 Serine Protease von Chen, Kevin X, Nair, Latha, Vibulbhan, Bancha, Yang, Weiying, Arasappan, Ashok, Bogen, Stephane L, Venkatraman, Srikanth, Bennett, Frank, Pan, Weidong, Blackman, Melissa L, Padilla, Angela I, Prongay, Andrew, Cheng, Kuo-Chi, Tong, Xiao, Shih, Neng-Yang, Njoroge, F. George

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Discovery of an irreversible HCV NS5B polymerase inhibitor von Zeng, Qingbei, Nair, Anilkumar G., Rosenblum, Stuart B., Huang, Hsueh-Cheng, Lesburg, Charles A., Jiang, Yueheng, Selyutin, Oleg, Chan, Tin-Yau, Bennett, Frank, Chen, Kevin X., Venkatraman, Srikanth, Sannigrahi, Mousumi, Velazquez, Francisco, Duca, Jose S., Gavalas, Stephen, Huang, Yuhua, Pu, Haiyan, Wang, Li, Pinto, Patrick, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Li, Cheng, Hesk, David, Gesell, Jennifer, Sorota, Steve, Shih, Neng-Yang, Njoroge, F. George, Kozlowski, Joseph A.

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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor von Bennett, Frank, Huang, Yuhua, Hendrata, Siska, Lovey, Raymond, Bogen, Stephane L., Pan, Weidong, Guo, Zhuyan, Prongay, Andrew, Chen, Kevin X., Arasappan, Ashok, Venkatraman, Srikanth, Velazquez, Francisco, Nair, Latha, Sannigrahi, Mousumi, Tong, Xiao, Pichardo, John, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor M., Saksena, Anil K., Njoroge, F. George

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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides von Anilkumar, Gopinadhan N., Selyutin, Oleg, Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Chan, Tin-Yau, Pu, Haiyan, Wang, Li, Bennett, Frank, Chen, Kevin X., Lesburg, Charles A., Duca, Jose, Gavalas, Stephen, Huang, Yuhua, Pinto, Patrick, Sannigrahi, Mousumi, Velazquez, Francisco, Venkatraman, Srikanth, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Huang, H.-C., Shih, Neng-Yang, George Njoroge, F., Kozlowski, Joseph A.

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Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease von Chen, Kevin X, Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor

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