PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells von Luff, Daisy H, Wojdyla, Katarzyna, Oxley, David, Chessa, Tamara, Hudson, Kevin, Hawkins, Phillip T, Stephens, Len R, Barry, Simon T, Okkenhaug, Klaus

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PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 + T-cell activity von Carnevalli, Larissa S, Sinclair, Charles, Taylor, Molly A, Gutierrez, Pablo Morentin, Langdon, Sophie, Coenen-Stass, Anna M L, Mooney, Lorraine, Hughes, Adina, Jarvis, Laura, Staniszewska, Anna, Crafter, Claire, Sidders, Ben, Hardaker, Elizabeth, Hudson, Kevin, Barry, Simon T

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The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose... von Maynard, Juliana, Emmas, Sally-Ann, Ble, Francois-Xavier, Barjat, Herve, Lawrie, Emily, Hancox, Urs, Polanska, Urszula M, Pritchard, Alison, Hudson, Kevin

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Who would most benefit from improved integrated care? Implementing an analytical strategy in South Somerset von Kasteridis, Panagiotis, Street, Andrew, Dolman, Matthew, Gallier, Lesley, Hudson, Kevin, Martin, Jeremy, Wyer, Ian

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Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL von Erdmann, Tabea, Klener, Pavel, Lynch, James T., Grau, Michael, Vočková, Petra, Molinsky, Jan, Tuskova, Diana, Hudson, Kevin, Polanska, Urszula M., Grondine, Michael, Mayo, Michele, Dai, Beiying, Pfeifer, Matthias, Erdmann, Kristian, Schwammbach, Daniela, Zapukhlyak, Myroslav, Staiger, Annette M., Ott, German, Berdel, Wolfgang E., Davies, Barry R., Cruzalegui, Francisco, Trneny, Marek, Lenz, Peter, Barry, Simon T., Lenz, Georg

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Endless Enigma: A Musical Biography of Emerson, Lake and Palmer by Edward Macan von Holm-Hudson, Kevin

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A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) von Ashford, Anne L, Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J, Lochhead, Pamela A

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Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation von Ward, Richard A, Brassington, Claire, Breeze, Alexander L, Caputo, Alessandro, Critchlow, Susan, Davies, Gareth, Goodwin, Louise, Hassall, Giles, Greenwood, Ryan, Holdgate, Geoffrey A, Mrosek, Michael, Norman, Richard A, Pearson, Stuart, Tart, Jonathan, Tucker, Julie A, Vogtherr, Martin, Whittaker, David, Wingfield, Jonathan, Winter, Jon, Hudson, Kevin

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Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer von Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Carnevalli, Larissa S, Hardaker, Elizabeth L, Maresca, Marcello, Hudson, Kevin, Harrington, Elizabeth A, Cruzalegui, Francisco

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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers von Hudson, Kevin, Hancox, Urs J, Trigwell, Cath, McEwen, Robert, Polanska, Urszula M, Nikolaou, Myria, Morentin Gutierrez, Pablo, Avivar-Valderas, Alvaro, Delpuech, Oona, Dudley, Phillippa, Hanson, Lyndsey, Ellston, Rebecca, Jones, Alys, Cumberbatch, Marie, Cosulich, Sabina C, Ward, Lara, Cruzalegui, Francisco, Green, Stephen

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A Generic Platform for Cellular Screening Against Ubiquitin Ligases von Maculins, Timurs, Carter, Nikki, Dorval, Thierry, Hudson, Kevin, Nissink, J. Willem M., Hay, Ronald T., Alwan, Husam

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Abstract 240: Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer von Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Ahmed, Ambar, Stetson, Daniel, Dougherty, Brian, Maresca, Marcello, Hudson, Kevin, Cruzalegui, Francisco

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The use of .sup.18F-Fluoro-deoxy-glucose positron emission tomography as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD883... von Maynard, Juliana, Emmas, Sally-Ann, Ble, Francois-Xavier, Barjat, Herve, Lawrie, Emily, Hancox, Urs, Polanska, Urszula M, Pritchard, Alison, Hudson, Kevin

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The use of .sup.18F-Fluoro-deoxy-glucose positron emission tomography von Maynard, Juliana, Emmas, Sally-Ann, Ble, Francois-Xavier, Barjat, Herve, Lawrie, Emily, Hancox, Urs, Polanska, Urszula M, Pritchard, Alison, Hudson, Kevin

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective... von Barlaam, Bernard, Cosulich, Sabina, Delouvrié, Bénédicte, Ellston, Rebecca, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hancox, Urs, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Lebraud, Honorine, Magnien, Françoise, Lamorlette, Maryannick, Le Griffon, Antoine, Morgentin, Rémy, Ouvry, Gilles, Page, Ken, Pasquet, Georges, Polanska, Urszula, Ruston, Linette, Saleh, Twana, Vautier, Michel, Ward, Lara

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Abstract 2668: Applying mechanistic PK/PD modeling to describe the efficacy of AZD8835 (PI3Kalpha/delta inhibitor) in a mouse xenograft breast tumor model at different dosing sched... von Morentin Gutierrez, Pablo, Hudson, Kevin, Hancox, Urs J., Ward, Lara T., Polanska, Urszula M., Cumberbatch, Marie, Cruzalegui, Francisco H.

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Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome von Ashford, Anne L, Dunkley, Tom P. J, Cockerill, Mark, Rowlinson, Rachel A, Baak, Lisa M, Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M, Ward, Richard A, Lochhead, Pamela A, Guichard, Sylvie, Hudson, Kevin, Cook, Simon J

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Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis von Kettle, Jason G, Ballard, Peter, Bardelle, Catherine, Cockerill, Mark, Colclough, Nicola, Critchlow, Susan E, Debreczeni, Judit, Fairley, Gary, Fillery, Shaun, Graham, Mark A, Goodwin, Louise, Guichard, Sylvie, Hudson, Kevin, Ward, Richard A, Whittaker, David

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Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients von GUINNEY, Justin, FERTE, Charles, DOUGHERTY, Brian, DUCREUX, Michel, SORIA, Jean-Charles, FRIEND, Stephen, DERRY, Jonathan, LAURENT-PUIG, Pierre, DRY, Jonathan, MCEWEN, Robert, MANCEAU, Gilles, KAO, K. J, CHANG, Kai-Ming, BENDTSEN, Claus, HUDSON, Kevin, ERICH HUANG

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Abstract 4524: A preclinical PKPD modeling & simulation strategy: building a predictive model of dose, schedule and therapeutic index for small molecule targeted anticancer agents von Jones, Rhys DO, Odedra, Rajesh, Yates, James WT, Morentin Gutierrez, Pablo, Davies, Barry, Hudson, Kevin, Barry, Simon T.

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