Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen von Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.

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FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair von Alcón, Pablo, Shakeel, Shabih, Chen, Zhuo A., Rappsilber, Juri, Patel, Ketan J., Passmore, Lori A.

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The Genetic and Biochemical Basis of FANCD2 Monoubiquitination von Rajendra, Eeson, Oestergaard, Vibe H., Langevin, Frédéric, Wang, Meng, Dornan, Gillian L., Patel, Ketan J., Passmore, Lori A.

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Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage von Gibbs-Seymour, Ian, Oka, Yasuyoshi, Rajendra, Eeson, Weinert, Brian T., Passmore, Lori A., Patel, Ketan J., Olsen, Jesper V., Choudhary, Chunaram, Bekker-Jensen, Simon, Mailand, Niels

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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice von Langevin, Frédéric, Crossan, Gerry P., Rosado, Ivan V., Arends, Mark J., Patel, Ketan J.

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TRAIP is a master regulator of DNA interstrand crosslink repair von Wu, R. Alex, Semlow, Daniel R., Kamimae-Lanning, Ashley N., Kochenova, Olga V., Chistol, Gheorghe, Hodskinson, Michael R., Amunugama, Ravindra, Sparks, Justin L., Wang, Meng, Deng, Lin, Mimoso, Claudia A., Low, Emily, Patel, Ketan J., Walter, Johannes C.

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Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function von Garaycoechea, Juan I., Crossan, Gerry P., Langevin, Frederic, Daly, Maria, Arends, Mark J., Patel, Ketan J.

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Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms von Hodskinson, Michael R., Bolner, Alice, Sato, Koichi, Kamimae-Lanning, Ashley N., Rooijers, Koos, Witte, Merlijn, Mahesh, Mohan, Silhan, Jan, Petek, Maya, Williams, David M., Kind, Jop, Chin, Jason W., Patel, Ketan J., Knipscheer, Puck

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Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells von Garaycoechea, Juan I., Crossan, Gerry P., Langevin, Frédéric, Mulderrig, Lee, Louzada, Sandra, Yang, Fentang, Guilbaud, Guillaume, Park, Naomi, Roerink, Sophie, Nik-Zainal, Serena, Stratton, Michael R., Patel, Ketan J.

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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism von Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.

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Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells von Bruemmer, Kevin J, Walvoord, Ryan R, Brewer, Thomas F, Burgos-Barragan, Guillermo, Wit, Niek, Pontel, Lucas B, Patel, Ketan J, Chang, Christopher J

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Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway von Pace, Paul, Mosedale, Georgina, Hodskinson, Michael R, Rosado, Ivan V, Sivasubramaniam, Meera, Patel, Ketan J

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A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells von Brewer, Thomas F, Burgos-Barragan, Guillermo, Wit, Niek, Patel, Ketan J, Chang, Christopher J

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Increased formate overflow is a hallmark of oxidative cancer von Meiser, Johannes, Schuster, Anne, Pietzke, Matthias, Vande Voorde, Johan, Athineos, Dimitris, Oizel, Kristell, Burgos-Barragan, Guillermo, Wit, Niek, Dhayade, Sandeep, Morton, Jennifer P., Dornier, Emmanuel, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Patel, Ketan J., Niclou, Simone P., Vazquez, Alexei

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Embracing cancer complexity: Hallmarks of systemic disease von Swanton, Charles, Bernard, Elsa, Abbosh, Chris, André, Fabrice, Auwerx, Johan, Balmain, Allan, Bar-Sagi, Dafna, Bernards, René, Bullman, Susan, DeGregori, James, Elliott, Catherine, Erez, Ayelet, Evan, Gerard, Febbraio, Mark A., Hidalgo, Andrés, Jamal-Hanjani, Mariam, Joyce, Johanna A., Kaiser, Matthew, Lamia, Katja, Locasale, Jason W., Loi, Sherene, Malanchi, Ilaria, Merad, Miriam, Musgrave, Kathryn, Patel, Ketan J., Quezada, Sergio, Wargo, Jennifer A., Weeraratna, Ashani, White, Eileen, Winkler, Frank, Wood, John N., Vousden, Karen H., Hanahan, Douglas

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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response von Mulderrig, Lee, Garaycoechea, Juan I., Tuong, Zewen K., Millington, Christopher L., Dingler, Felix A., Ferdinand, John R., Gaul, Liam, Tadross, John A., Arends, Mark J., O’Rahilly, Stephen, Crossan, Gerry P., Clatworthy, Menna R., Patel, Ketan J.

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Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair von Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.

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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia von Crossan, Gerry P, van der Weyden, Louise, Rosado, Ivan V, Langevin, Frederic, Gaillard, Pierre-Henri L, McIntyre, Rebecca E, Gallagher, Ferdia, Kettunen, Mikko I, Lewis, David Y, Brindle, Kevin, Arends, Mark J, Adams, David J, Patel, Ketan J

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Structure of the Fanconi anaemia monoubiquitin ligase complex von Shakeel, Shabih, Rajendra, Eeson, Alcón, Pablo, O’Reilly, Francis, Chorev, Dror S., Maslen, Sarah, Degliesposti, Gianluca, Russo, Christopher J., He, Shaoda, Hill, Chris H., Skehel, J. Mark, Scheres, Sjors H. W., Patel, Ketan J., Rappsilber, Juri, Robinson, Carol V., Passmore, Lori A.

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The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA von Crossan, Gerry P, Patel, Ketan J

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