Genetic architecture of human thinness compared to severe obesity von Riveros-McKay, Fernando, Mistry, Vanisha, Bounds, Rebecca, Hendricks, Audrey, Keogh, Julia M, Thomas, Hannah, Henning, Elana, Corbin, Laura J, O'Rahilly, Stephen, Zeggini, Eleftheria, Wheeler, Eleanor, Barroso, Inês, Farooqi, I Sadaf

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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance von van der Klaauw, Agatha A., Croizier, Sophie, Mendes de Oliveira, Edson, Stadler, Lukas K.J., Park, Soyoung, Kong, Youxin, Banton, Matthew C., Tandon, Panna, Hendricks, Audrey E., Keogh, Julia M., Riley, Susanna E., Papadia, Sofia, Henning, Elana, Bounds, Rebecca, Bochukova, Elena G., Mistry, Vanisha, O’Rahilly, Stephen, Simerly, Richard B., Minchin, James E.N., Barroso, Inês, Jones, E. Yvonne, Bouret, Sebastien G., Farooqi, I. Sadaf

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Leptin Mediates the Increase in Blood Pressure Associated with Obesity von Simonds, Stephanie E., Pryor, Jack T., Ravussin, Eric, Greenway, Frank L., Dileone, Ralph, Allen, Andrew M., Bassi, Jaspreet, Elmquist, Joel K., Keogh, Julia M., Henning, Elana, Myers, Martin G., Licinio, Julio, Brown, Russell D., Enriori, Pablo J., O’Rahilly, Stephen, Sternson, Scott M., Grove, Kevin L., Spanswick, David C., Farooqi, I. Sadaf, Cowley, Michael A.

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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency von Collet, Tinh-Hai, Dubern, Béatrice, Mokrosinski, Jacek, Connors, Hillori, Keogh, Julia M., Mendes de Oliveira, Edson, Henning, Elana, Poitou-Bernert, Christine, Oppert, Jean-Michel, Tounian, Patrick, Marchelli, Florence, Alili, Rohia, Le Beyec, Johanne, Pépin, Dominique, Lacorte, Jean-Marc, Gottesdiener, Andrew, Bounds, Rebecca, Sharma, Shubh, Folster, Cathy, Henderson, Bart, O'Rahilly, Stephen, Stoner, Elizabeth, Gottesdiener, Keith, Panaro, Brandon L., Cone, Roger D., Clément, Karine, Farooqi, I. Sadaf, Van der Ploeg, Lex H.T.

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KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation von Pearce, Laura R., Atanassova, Neli, Banton, Matthew C., Bottomley, Bill, van der Klaauw, Agatha A., Revelli, Jean-Pierre, Hendricks, Audrey, Keogh, Julia M., Henning, Elana, Doree, Deon, Jeter-Jones, Sabrina, Garg, Sumedha, Bochukova, Elena G., Bounds, Rebecca, Ashford, Sofie, Gayton, Emma, Hindmarsh, Peter C., Shield, Julian P.H., Crowne, Elizabeth, Barford, David, Wareham, Nick J., O’Rahilly, Stephen, Murphy, Michael P., Powell, David R., Barroso, Ines, Farooqi, I. Sadaf

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A Mutation in the Thyroid Hormone Receptor Alpha Gene von Bochukova, Elena, Schoenmakers, Nadia, Schoenmakers, Erik, Agostini, Maura, Rajanayagam, Odelia, Keogh, Julia M, Henning, Elana, Reinemund, Jana, Gevers, Evelien, Sarri, Margarita, Downes, Kate, Offiah, Amaka, Albanese, Assunta, Halsall, David, Schwabe, John W.R, Bain, Murray, Lindley, Keith, Muntoni, Francesco, Khadem, Faraneh Vargha, Dattani, Mehul, Farooqi, I. Sadaf, Gurnell, Mark, Chatterjee, Krishna

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Leptin-Mediated Changes in the Human Metabolome von Lawler, Katherine, Huang-Doran, Isabel, Sonoyama, Takuhiro, Collet, Tinh-Hai, Keogh, Julia M, Henning, Elana, O’Rahilly, Stephen, Bottolo, Leonardo, Farooqi, I Sadaf

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A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome von Bochukova, Elena G., Lawler, Katherine, Croizier, Sophie, Keogh, Julia M., Patel, Nisha, Strohbehn, Garth, Lo, Kitty K., Humphrey, Jack, Hokken-Koelega, Anita, Damen, Layla, Donze, Stephany, Bouret, Sebastien G., Plagnol, Vincent, Farooqi, I. Sadaf

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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation von Brouwers, Bas, de Oliveira, Edson Mendes, Marti-Solano, Maria, Monteiro, Fabiola B.F., Laurin, Suli-Anne, Keogh, Julia M., Henning, Elana, Bounds, Rebecca, Daly, Carole A., Houston, Shane, Ayinampudi, Vikram, Wasiluk, Natalia, Clarke, David, Plouffe, Bianca, Bouvier, Michel, Babu, M. Madan, Farooqi, I. Sadaf, Mokrosiński, Jacek

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High protein intake stimulates postprandial GLP1 and PYY release von Klaauw, Agatha A., Keogh, Julia M., Henning, Elana, Trowse, Victoria M., Dhillo, Waljit S., Ghatei, Mohammad A., Farooqi, I. Sadaf

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Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila von Agrawal, Neha, Lawler, Katherine, Davidson, Catherine M, Keogh, Julia M, Legg, Robert, Barroso, Inês, Farooqi, I Sadaf, Brand, Andrea H

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Modulation of Blood Pressure by Central Melanocortinergic Pathways von Greenfield, Jerry R, Miller, Jeffrey W, Keogh, Julia M, Henning, Elana, Satterwhite, Julie H, Cameron, Gregory S, Astruc, Beatrice, Mayer, John P, Brage, Soren, See, Teik Choon, Lomas, David J, O'Rahilly, Stephen, Farooqi, I. Sadaf

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A rare human variant that disrupts GPR10 signalling causes weight gain in mice von Talbot, Fleur, Feetham, Claire H., Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M., Henning, Elana, Mendes de Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S. H., Froguel, Philippe, Bechtold, David A., Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M., Farooqi, I. Sadaf

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Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects von Greenfield, Jerry R, Farooqi, I Sadaf, Keogh, Julia M, Henning, Elana, Habib, Abdella M, Blackwood, Anthea, Reimann, Frank, Holst, Jens J, Gribble, Fiona M

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Divergent effects of central melanocortin signalling on fat and sucrose preference in humans von van der Klaauw, Agatha A., Keogh, Julia M., Henning, Elana, Stephenson, Cheryl, Kelway, Sarah, Trowse, Victoria M., Subramanian, Naresh, O’Rahilly, Stephen, Fletcher, Paul C., Farooqi, I. Sadaf

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Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene von Farooqi, I. Sadaf, Keogh, Julia M, Yeo, Giles S.H, Lank, Emma J, Cheetham, Tim, O'Rahilly, Stephen

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The central melanocortin system directly controls peripheral lipid metabolism von Nogueiras, Ruben, Wiedmer, Petra, Perez-Tilve, Diego, Veyrat-Durebex, Christelle, Keogh, Julia M, Sutton, Gregory M, Pfluger, Paul T, Castaneda, Tamara R, Neschen, Susanne, Hofmann, Susanna M, Howles, Philip N, Morgan, Donald A, Benoit, Stephen C, Szanto, Ildiko, Schrott, Brigitte, Schürmann, Annette, Joost, Hans-Georg, Hammond, Craig, Hui, David Y, Woods, Stephen C, Rahmouni, Kamal, Butler, Andrew A, Farooqi, I Sadaf, O'Rahilly, Stephen, Rohner-Jeanrenaud, Françoise, Tschöp, Matthias H

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Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene von GRAY, Juliette, YEO, Giles S. H, HODGES, John R, RAYMOND, F. Lucy, O'RAHILLY, Stephen, SADAF FAROOQI, I, COX, James J, MORTON, Jenny, ADLAM, Anna-Lynne R, KEOGH, Julia M, YANOVSKI, Jack A, EL GHARBAWY, Areeg, HAN, Joan C, LORAINE TUNG, Y. C

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Oxytocin administration suppresses hypothalamic activation in response to visual food cues von van der Klaauw, Agatha A., Ziauddeen, Hisham, Keogh, Julia M., Henning, Elana, Dachi, Sekesai, Fletcher, Paul C., Farooqi, I. Sadaf

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Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans von SADAF FAROOQI, I, DROP, Stenvert, CLEMENTS, Agnes, KEOGH, Julia M, BIERNACKA, Joanna, LOWENBEIN, Sarah, CHALLIS, Benjamin G, O'RAHILLY, Stephen

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