Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance von Krishnan, Preethi, Smith, Andrew K, Ropella, Glen E. P, Dutta, Lopamudra, Kennedy, Ryan C, Hunt, C. Anthony

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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments von Smith, Andrew K, Petersen, Brenden K, Ropella, Glen E P, Kennedy, Ryan C, Kaplowitz, Neil, Ookhtens, Murad, Hunt, C Anthony

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Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms von Smith, Andrew K., Ropella, Glen E. P., McGill, Mitchell R., Krishnan, Preethi, Dutta, Lopamudra, Kennedy, Ryan C., Jaeschke, Hartmut, Hunt, C. Anthony

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Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange von Kennedy, Ryan C, Smith, Andrew K, Ropella, Glen E P, McGill, Mitchell R, Jaeschke, Hartmut, Hunt, C Anthony

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Simulation enabled search for explanatory mechanisms of the fracture healing process von Kennedy, Ryan C, Marmor, Meir, Marcucio, Ralph, Hunt, C Anthony

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Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi von Jiang, Xiaofang, Peery, Ashley, Hall, A Brantley, Sharma, Atashi, Chen, Xiao-Guang, Waterhouse, Robert M, Komissarov, Aleksey, Riehle, Michelle M, Shouche, Yogesh, Sharakhova, Maria V, Lawson, Dan, Pakpour, Nazzy, Arensburger, Peter, Davidson, Victoria L M, Eiglmeier, Karin, Emrich, Scott, George, Phillip, Kennedy, Ryan C, Mane, Shrinivasrao P, Maslen, Gareth, Oringanje, Chioma, Qi, Yumin, Settlage, Robert, Tojo, Marta, Tubio, Jose M C, Unger, Maria F, Wang, Bo, Vernick, Kenneth D, Ribeiro, Jose M C, James, Anthony A, Michel, Kristin, Riehle, Michael A, Luckhart, Shirley, Sharakhov, Igor V, Tu, Zhijian

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An automated homology-based approach for identifying transposable elements von Kennedy, Ryan C, Unger, Maria F, Christley, Scott, Collins, Frank H, Madey, Gregory R

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Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase 1/2 o... von Lentzsch, Suzanne, O'Sullivan, Amy, Kennedy, Ryan C., Abbas, Mohammad, Dai, Lijun, Pregja, Silvana Lalo, Burt, Steve, Boyiadzis, Michael, Roodman, G. David, Mapara, Markus Y., Agha, Mounzer, Waas, John, Shuai, Yongli, Normolle, Daniel, Zonder, Jeffrey A.

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Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity von Hunt, C. Anthony, Kennedy, Ryan C., Kim, Sean H. J., Ropella, Glen E. P.

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VectorBase: a home for invertebrate vectors of human pathogens von Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J, Bruggner, Robert V, Butler, Ryan, Campbell, Kathryn S, Christophides, George K, Christley, Scott, Dialynas, Emmanuel, Emmert, David, Hammond, Martin, Hill, Catherine A, Kennedy, Ryan C

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A cell-centered, agent-based framework that enables flexible environment granularities von Kennedy, Ryan C, Ropella, Glen Ep, Hunt, C Anthony

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VectorBase: a home for invertebrate vectors of human pathogens von Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J., Bruggner, Robert V., Butler, Ryan, Campbell, Kathryn S., Christophides, George K., Christley, Scott, Dialynas, Emmanuel, Emmert, David, Hammond, Martin, Hill, Catherine A., Kennedy, Ryan C., Lobo, Neil F., MacCallum, M. Robert, Madey, Greg, Megy, Karine, Redmond, Seth, Russo, Susan, Severson, David W., Stinson, Eric O., Topalis, Pantelis, Zdobnov, Evgeny M., Birney, Ewan, Gelbart, William M., Kafatos, Fotis C., Louis, Christos, Collins, Frank H.

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test of agent-based models as a tool for predicting patterns of pathogen transmission in complex landscapes von Lane-deGraaf, Kelly E, Kennedy, Ryan C, Arifin, SM Niaz, Madey, Gregory R, Fuentes, Agustin, Hollocher, Hope

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In vitro–in vivo extrapolation of hepatic clearance: using virtual experiments to identify a plausibly influential source of inaccuracies von Hunt, C. Anthony, Smith, Andrew K., Ropella, Glen E. P., Kennedy, Ryan C.

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Contrasting model mechanisms of alanine aminotransferase von Smith, Andrew K, Ropella, Glen E. P, McGill, Mitchell R, Krishnan, Preethi, Dutta, Lopamudra, Kennedy, Ryan C, Jaeschke, Hartmut, Hunt, C. Anthony

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Falsifying an Enzyme Induction Mechanism within a Validated, Multiscale Liver Model von Ropella, Glen E. P, Kennedy, Ryan C, Hunt, C Anthony

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A Phase I Study of Bendamustine Combined with Lenalidomide and Dexamethasone in Patients with Refractory or Relapsed Multiple Myeloma von Lentzsch, Suzanne, O'Sullivan, Amy, Lalo, Silvana, Kruppa, Carrie, Gardner, Diane, Kennedy, Ryan C, Burt, Steve, Mapara, Markus Y, Redner, Robert, Roodman, David, Volkin, Robert L, Zonder, Jeffrey

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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics von ARENSBURGER, Peter, MEGY, Karine, CAMPBELL, Corey L, CAMPBELL, Kathryn S, CASOLA, Claudio, CASTRO, Marta T, CHANDRAMOULISWARAN, Ishwar, CHAPMAN, Sinéad B, CHRISTLEY, Scott, COSTAS, Javier, EISENSTADT, Eric, FESCHOTTE, Cedric, WATERHOUSE, Robert M, FRASER-LIGGETT, Claire, GUIGO, Roderic, HAAS, Brian, HAMMOND, Martin, HANSSON, Bill S, HEMINGWAY, Janet, HILL, Sharon R, HOWARTH, Clint, IGNELL, Rickard, KENNEDY, Ryan C, ABRUDAN, Jenica, KODIRA, Chinnappa D, LOBO, Neil F, CHUNHONG MAO, MAYHEW, George, MICHEL, Kristin, MORI, Akio, NANNAN LIU, NAVEIRA, Horacio, NENE, Vishvanath, NGUYEN, Nam, AMEDEO, Paolo, PEARSON, Matthew D, PRITHAM, Ellen J, PUIU, Daniela, YUMIN QI, RANSON, Hilary, RIBEIRO, Jose M. C, ROBERSTON, Hugh M, SEVERSON, David W, SHUMWAY, Martin, STANKE, Mario, ANTELO, Beatriz, STRAUSBERG, Robert L, CHENG SUN, SUTTON, Granger, ZHIJIAN TU, TUBIO, Jose Manuel C, UNGER, Maria F, VANLANDINGHAM, Dana L, VILELLA, Albert J, WHITE, Owen, WHITE, Jared R, BARTHOLOMAY, Lyric, BIDWELL, Shelby, CALER, Elisabet, CAMARA, Francisco

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Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World von Labbé, Frédéric, Abdeladhim, Maha, Abrudan, Jenica, Araki, Alejandra Saori, Araujo, Ricardo N, Arensburger, Peter, Benoit, Joshua B, Brazil, Reginaldo Pecanha, Bruno, Rafaela V, Bueno da Silva Rivas, Gustavo, Carvalho de Abreu, Vinicius, Charamis, Jason, Coutinho-Abreu, Iliano V, da Costa-Latgé, Samara G, Darby, Alistair, Dillon, Viv M, Emrich, Scott J, Fernandez-Medina, Daniela, Figueiredo Gontijo, Nelder, Flanley, Catherine M, Gatherer, Derek, Genta, Fernando A, Gesing, Sandra, Giraldo-Calderón, Gloria I, Gomes, Bruno, Aguiar, Eric Roberto Guimaraes Rocha, Hamilton, James G. C, Hamarsheh, Omar, Hawksworth, Mallory, Hendershot, Jacob M, Hickner, Paul V, Imler, Jean-Luc, Ioannidis, Panagiotis, Jennings, Emily C, Kamhawi, Shaden, Karageorgiou, Charikleia, Kennedy, Ryan C, Krueger, Andreas, Latorre-Estivalis, José M, Ligoxygakis, Petros, Meireles-Filho, Antonio Carlos A, Minx, Patrick, Miranda, Jose Carlos, Montague, Michael J, Nowling, Ronald J, Oliveira, Fabiano, Ortigão-Farias, João, Pavan, Marcio G, Horacio Pereira, Marcos, Nobrega Pitaluga, Andre, Proveti Olmo, Roenick, Ramalho-Ortigao, Marcelo, Ribeiro, José M. C, Rosendale, Andrew J, Sant'Anna, Mauricio R. V, Scherer, Steven E, Secundino, Nágila F. C, Shoue, Douglas A, da Silva Moraes, Caroline, Gesto, João Silveira Moledo, Souza, Nataly Araujo, Syed, Zainulabueddin, Tadros, Samuel, Teles-de-Freitas, Rayane, Telleria, Erich L, Tomlinson, Chad, Traub-Csekö, Yara M, Marques, João Trindade, Tu, Zhijian, Unger, Maria F, Valenzuela, Jesus, Ferreira, Flávia V, de Oliveira, Karla P. V, Vigoder, Felipe M, Vontas, John, Wang, Lihui, Weedall, Gareth D, Zhioua, Elyes, Richards, Stephen, Warren, Wesley, Waterhouse, Robert M, Dillon, Rod J, McDowell, Mary Ann

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DETERMINATION OF PATIENT PRESCRIPTION RELATIONSHIPS AND BEHAVIORS von Bostic, Bradley A, Kennedy, Ryan C, Clarke, Charles J, Plantes, Peter J, Girard, Jr., Charles David

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