CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy von Siddiqui-Jain, Adam, Drygin, Denis, Streiner, Nicole, Chua, Peter, Pierre, Fabrice, O'Brien, Sean E, Bliesath, Josh, Omori, Mayuko, Huser, Nanni, Ho, Caroline, Proffitt, Chris, Schwaebe, Michael K, Ryckman, David M, Rice, William G, Anderes, Kenna

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Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53 von Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A., Hannan, Ross D.

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Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis von DRYGIN, Denis, SIDDIQUI-JAIN, Adam, LIM, John K. C, VON HOFF, Daniel, ANDERES, Kenna, RICE, William G, O'BRIEN, Sean, SCHWAEBE, Michael, LIN, Amy, BLIESATH, Josh, HO, Caroline B, PROFFITT, Chris, TRENT, Katy, WHITTEN, Jeffrey P

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Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Ca... von Pierre, Fabrice, Chua, Peter C, O’Brien, Sean E, Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K, Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P, Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Anderes, Kenna, Bliesath, Josh, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Trent, Katy, Rice, William G, Ryckman, David M

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Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer von Battistutta, Roberto, Cozza, Giorgio, Pierre, Fabrice, Papinutto, Elena, Lolli, Graziano, Sarno, Stefania, O’Brien, Sean E, Siddiqui-Jain, Adam, Haddach, Mustapha, Anderes, Kenna, Ryckman, David M, Meggio, Flavio, Pinna, Lorenzo A

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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia von Martins, Leila R., Lúcio, Paulo, Silva, Milene C., Anderes, Kenna L., Gameiro, Paula, Silva, Maria G., Barata, João T.

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 von Blasina, Alessandra, Hallin, Jill, Chen, Enhong, Arango, Maria Elena, Kraynov, Eugenia, Register, James, Grant, Stephan, Ninkovic, Sacha, Chen, Ping, Nichols, Tim, O'Connor, Patrick, Anderes, Kenna

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CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy von Siddiqui-Jain, Adam, Bliesath, Joshua, Macalino, Diwata, Omori, Mayuko, Huser, Nanni, Streiner, Nicole, Ho, Caroline B, Anderes, Kenna, Proffitt, Chris, O'Brien, Sean E, Lim, John K C, Von Hoff, Daniel D, Ryckman, David M, Rice, William G, Drygin, Denis

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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer von Pierre, Fabrice, Chua, Peter C., O’Brien, Sean E., Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K., Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P., Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Bliesath, Joshua, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Rice, William G., Ryckman, David M., Anderes, Kenna

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ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine von Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul

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Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer von Drygin, Denis, Ho, Caroline B., Omori, Mayuko, Bliesath, Joshua, Proffitt, Chris, Rice, Rachel, Siddiqui-Jain, Adam, O’Brien, Sean, Padgett, Claire, Lim, John K.C., Anderes, Kenna, Rice, William G., Ryckman, David

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Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells von Bliesath, Joshua, Huser, Nanni, Omori, Mayuko, Bunag, Daniel, Proffitt, Chris, Streiner, Nicole, Ho, Caroline, Siddiqui-Jain, Adam, O’Brien, Sean E, Lim, John K.C, Ryckman, David M, Anderes, Kenna, Rice, William G, Drygin, Denis

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Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics von Haddach, Mustapha, Schwaebe, Michael K, Michaux, Jerome, Nagasawa, Johnny, O'Brien, Sean E, Whitten, Jeffrey P, Pierre, Fabrice, Kerdoncuff, Pauline, Darjania, Levan, Stansfield, Ryan, Drygin, Denis, Anderes, Kenna, Proffitt, Chris, Bliesath, Josh, Siddiqui-Jain, Adam, Omori, May, Huser, Nanni, Rice, William G, Ryckman, David M

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Isolation of Circulating Tumor Cells from Multiple Epithelial Cancers with ApoStream® for Detecting (or Monitoring) the Expression of Folate Receptor Alpha von O'Shannessy, Daniel J., Davis, Darren W., Anderes, Kenna, Somers, Elizabeth B.

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Identification and Validation of Inhibitor-Responsive Kinase Substrates Using a New Paradigm To Measure Kinase-Specific Protein Phosphorylation Index von Li, Xiang, Rao, Varsha, Jin, Jin, Guan, Bin, Anderes, Kenna L, Bieberich, Charles J

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PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts von ZHANG, Cathy, ZHENGMINGYAN, WONG, Anthony, BUCKMAN, Dana, GUIZHEN SUN, MING QIU, ANDERES, Kenna, CHRISTENSEN, James G, PAINTER, Cory L, QIN ZHANG, ENHONG CHEN, ARANGO, Maria E, KUSZPIT, Kyle, ZASADNY, Kenneth, HALLIN, Max, HALLIN, Jill

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Advancing Bioluminescence Imaging Technology for the Evaluation of Anticancer Agents in the MDA-MB-435-HAL-Luc Mammary Fat Pad and Subrenal Capsule Tumor Models von Zhang, Cathy, Yan, Zhengming, Arango, Maria E, Painter, Cory L, Anderes, Kenna

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Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor von Haddach, Mustapha, Michaux, Jerome, Schwaebe, Michael K, Pierre, Fabrice, O’Brien, Sean E, Borsan, Cosmin, Tran, Joe, Raffaele, Nicholas, Ravula, Suchitra, Drygin, Denis, Siddiqui-Jain, Adam, Darjania, Levan, Stansfield, Ryan, Proffitt, Chris, Macalino, Diwata, Streiner, Nicole, Bliesath, Joshua, Omori, May, Whitten, Jeffrey P, Anderes, Kenna, Rice, William G, Ryckman, David M

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Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation von Jänne, Pasi A., Riely, Gregory J., Gadgeel, Shirish M., Heist, Rebecca S., Ou, Sai-Hong I., Pacheco, Jose M., Johnson, Melissa L., Sabari, Joshua K., Leventakos, Konstantinos, Yau, Edwin, Bazhenova, Lyudmila, Negrao, Marcelo V., Pennell, Nathan A., Zhang, Jun, Anderes, Kenna, Der-Torossian, Hirak, Kheoh, Thian, Velastegui, Karen, Yan, Xiaohong, Christensen, James G., Chao, Richard C., Spira, Alexander I.

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Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetram... von Madsen, Peter, Ling, Anthony, Plewe, Michael, Sams, Christian K, Knudsen, Lotte B, Sidelmann, Ulla G, Ynddal, Lars, Brand, Christian L, Andersen, Birgitte, Murphy, Douglas, Teng, Min, Truesdale, Larry, Kiel, Dan, May, John, Kuki, Atsuo, Shi, Shenghua, Johnson, Michael D, Teston, Kimberly Ann, Feng, Jun, Lakis, James, Anderes, Kenna, Gregor, Vlad, Lau, Jesper

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