SARS-CoV-2 variant Delta rapidly displaced variant Alpha in the United States and led to higher viral loads von Bolze, Alexandre, Luo, Shishi, White, Simon, Cirulli, Elizabeth T., Wyman, Dana, Dei Rossi, Andrew, Machado, Henrique, Cassens, Tyler, Jacobs, Sharoni, Schiabor Barrett, Kelly M., Tanudjaja, Francisco, Tsan, Kevin, Nguyen, Jason, Ramirez, Jimmy M., Sandoval, Efren, Wang, Xueqing, Wong, David, Becker, David, Laurent, Marc, Lu, James T., Isaksson, Magnus, Washington, Nicole L., Lee, William

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Semaglutide vs Tirzepatide Dosages for Weight Loss von Levy, Matthew E, Schiabor Barrett, Kelly M, Cirulli, Elizabeth T

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A power-based sliding window approach to evaluate the clinical impact of rare genetic variants in the nucleotide sequence or the spatial position of the folded protein von Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, Judge, Daniel P., Pawloski, Pamala A., Grzymski, Joseph J., Lee, William, Washington, Nicole L.

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Cardiomyopathy prevalence exceeds 30% in individuals with TTN variants and early atrial fibrillation von Schiabor Barrett, Kelly M., Cirulli, Elizabeth T., Bolze, Alexandre, Rowan, Chris, Elhanan, Gai, Grzymski, Joseph J., Lee, William, Washington, Nicole L.

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Clinical validation of genomic functional screen data: Analysis of observed BRCA1 variants in an unselected population cohort von Schiabor Barrett, Kelly M., Masnick, Max, Hatchell, Kathryn E., Savatt, Juliann M., Banet, Natalie, Buchanan, Adam, Willard, Huntington F.

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Positive predictive value highlights four novel candidates for actionable genetic screening from analysis of 220,000 clinicogenomic records von Schiabor Barrett, Kelly M., Bolze, Alexandre, Ni, Yunyun, White, Simon, Isaksson, Magnus, Sharma, Lavania, Levin, Elissa, Lee, William, Grzymski, Joseph J., Lu, James T., Washington, Nicole L., Cirulli, Elizabeth T.

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HLA-A∗03:01 is associated with increased risk of fever, chills, and stronger side effects from Pfizer-BioNTech COVID-19 vaccination von Bolze, Alexandre, Neveux, Iva, Schiabor Barrett, Kelly M., White, Simon, Isaksson, Magnus, Dabe, Shaun, Lee, William, Grzymski, Joseph J., Washington, Nicole L., Cirulli, Elizabeth T.

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Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States von Washington, Nicole L., Gangavarapu, Karthik, Zeller, Mark, Bolze, Alexandre, Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Larsen, Brendan B., Anderson, Catelyn, White, Simon, Cassens, Tyler, Jacobs, Sharoni, Levan, Geraint, Nguyen, Jason, Ramirez, Jimmy M., Rivera-Garcia, Charlotte, Sandoval, Efren, Wang, Xueqing, Wong, David, Spencer, Emily, Robles-Sikisaka, Refugio, Kurzban, Ezra, Hughes, Laura D., Deng, Xianding, Wang, Candace, Servellita, Venice, Valentine, Holly, De Hoff, Peter, Seaver, Phoebe, Sathe, Shashank, Gietzen, Kimberly, Sickler, Brad, Antico, Jay, Hoon, Kelly, Liu, Jingtao, Harding, Aaron, Bakhtar, Omid, Basler, Tracy, Austin, Brett, MacCannell, Duncan, Isaksson, Magnus, Febbo, Phillip G., Becker, David, Laurent, Marc, McDonald, Eric, Yeo, Gene W., Knight, Rob, Laurent, Louise C., de Feo, Eileen, Worobey, Michael, Chiu, Charles Y., Suchard, Marc A., Lu, James T., Lee, William, Andersen, Kristian G.

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Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes von Schiabor Barrett, Kelly M., Telis, Natalie, McEwen, Lisa M., Burrows, Evanette K., Khuder, Basil, Judge, Daniel P., Pawloski, Pamala A., Grzymski, Joseph J., Washington, Nicole L., Bolze, Alexandre, Cirulli, Elizabeth T.

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Combining rare and common genetic variants improves population risk stratification for breast cancer von Bolze, Alexandre, Kiser, Daniel, Schiabor Barrett, Kelly M., Elhanan, Gai, Schnell Blitstein, Jamie M., Neveux, Iva, Dabe, Shaun, Reed, Harry, Anderson, Alexa, Metcalf, William J., Orlova, Ekaterina, Thibodeau, Ildiko, Telis, Natalie, Jiang, Ruomu, Washington, Nicole L., Ferber, Matthew J., Hajek, Catherine, Cirulli, Elizabeth T., Grzymski, Joseph J.

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Abstract 13601: An Evidence-Based Population Screening Strategy for TTN : Statistical Analysis of Over 450,000 Clinicogeomic Records Reveals High Prevalence of Cardiomyopathy in Ca... von Schiabor Barrett, Kelly M, Cirulli, Elizabeth T, Bolze, Alexandre, Rowan, Chris, Elhanan, Gai, Grzymski, Joseph J, Lee, William, Washington, Nicole L

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Abstract 13601: An Evidence-Based Population Screening Strategy for TTN: Statistical Analysis of Over 450,000 Clinicogeomic Records Reveals High Prevalence of Cardiomyopathy in Car... von Schiabor Barrett, Kelly M, Cirulli, Elizabeth T, Bolze, Alexandre, Rowan, Chris, Elhanan, Gai, Grzymski, Joseph J, Lee, William, Washington, Nicole L

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Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative von Butler-Laporte, Guillaume, Povysil, Gundula, Kosmicki, Jack A, Cirulli, Elizabeth T, Drivas, Theodore, Furini, Simone, Saad, Chadi, Schmidt, Axel, Olszewski, Pawel, Korotko, Urszula, Quinodoz, Mathieu, Çelik, Elifnaz, Kundu, Kousik, Walter, Klaudia, Jung, Junghyun, Stockwell, Amy D, Sloofman, Laura G, Jordan, Daniel M, Thompson, Ryan C, Del Valle, Diane, Simons, Nicole, Cheng, Esther, Sebra, Robert, Schadt, Eric E, Kim-Schulze, Seunghee, Gnjatic, Sacha, Merad, Miriam, Buxbaum, Joseph D, Beckmann, Noam D, Charney, Alexander W, Przychodzen, Bartlomiej, Chang, Timothy, Pottinger, Tess D, Shang, Ning, Brand, Fabian, Fava, Francesca, Mari, Francesca, Chwialkowska, Karolina, Niemira, Magdalena, Pula, Szymon, Baillie, J Kenneth, Stuckey, Alex, Salas, Antonio, Bello, Xabier, Pardo-Seco, Jacobo, Gómez-Carballa, Alberto, Rivero-Calle, Irene, Martinón-Torres, Federico, Ganna, Andrea, Karczewski, Konrad J, Veerapen, Kumar, Bourgey, Mathieu, Bourque, Guillaume, Eveleigh, Robert Jm, Forgetta, Vincenzo, Morrison, David, Langlais, David, Lathrop, Mark, Mooser, Vincent, Nakanishi, Tomoko, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklos, Marincevic-Zuniga, Yanara, Nordlund, Jessica, Schiabor Barrett, Kelly M, Lee, William, Bolze, Alexandre, White, Simon, Riffle, Stephen, Tanudjaja, Francisco, Sandoval, Efren, Neveux, Iva, Dabe, Shaun, Casadei, Nicolas, Motameny, Susanne, Alaamery, Manal, Massadeh, Salam, Aljawini, Nora, Almutairi, Mansour S, Arabi, Yaseen M, Alqahtani, Saleh A, Al Harthi, Fawz S, Almutairi, Amal, Alqubaishi, Fatima, Alotaibi, Sarah, Binowayn, Albandari, Alsolm, Ebtehal A, El Bardisy, Hadeel, Fawzy, Mohammad, Cai, Fang, Soranzo, Nicole, Butterworth, Adam, Geschwind, Daniel H, Arteaga, Stephanie, Stephens, Alexis, Butte, Manish J, Boutros, Paul C, Yamaguchi, Takafumi N, Tao, Shu

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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection von Marchal, Astrid, Cirulli, Elizabeth T, Neveux, Iva, Bellos, Evangelos, Thwaites, Ryan S, Barrett, Kelly M. Schiabor, Zhang, Yu, Nemes-Bokun, Ivana, Kalinova, Mariya, Catchpole, Andrew, Tangye, Stuart G, Spaan, Andras N, Lack, Justin B, Ghosn, Jade, Burdet, Charles, Gorochov, Guy, Tubach, Florence, Hausfater, Pierre, Dalgard, Clifton L, Zhang, Shen-Ying, Zhang, Qian, Chiu, Christopher, Fellay, Jacques, Grzymski, Joseph J, Sancho-Shimizu, Vanessa, Abel, Laurent, Casanova, Jean-Laurent, Cobat, Aurelie, Bolze, Alexandre, Haerynck, Filomeen, Tavernier, Simon, Van Praet, Jens, Lambrecht, Bart, Van Braeckel, Eva, Bosteels, Cedric, Hoste, Levi, Hoste, Eric, Bauters, Fre, Declercq, Jozefien, Naesens, Leslie, COVIDeF Study Grp, [missing], French COVID Cohort Study Grp, [missing], CoV-Contact Cohort, [missing], COVID-STORM Clinicians, [missing], COVID Clinicians, [missing], Orchestra Working Grp, [missing], Amsterdam UMC COVID-19 Biobank, [missing], AID-USUHSCOVID Study Grp, [missing], COVID Study Grp, [missing]

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Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility von Irene V van Blokland, Pauline Lanting, Anil P S Ori, Judith M Vonk, Robert C A Warmerdam, Johanna C Herkert, Floranne Boulogne, Annique Claringbould, Esteban A Lopera-Maya, Meike Bartels, Jouke-Jan Hottenga, Andrea Ganna, Juha Karjalainen, Lifelines COVID-19 cohort study, COVID-19 Host Genetics Initiative, Caroline Hayward, Chloe Fawns-Ritchie, Archie Campbell, David Porteous, Elizabeth T Cirulli, Kelly M Schiabor Barrett, Stephen Riffle, Alexandre Bolze, Simon White, Francisco Tanudjaja, Xueqing Wang, Jimmy M Ramirez, Yan Wei Lim, James T Lu, Nicole L Washington, Eco J C de Geus, Patrick Deelen, H Marike Boezen, Lude H Franke

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